Metabolism of Drugs. LXIV. Species Differences of Metabolism of Phenacetylurea
In our previous papers, it was shown that phenacetylurea administered to rabbits is metabolized to 3-methoxy-4-hydroxyphenacetylurea, but in mice it is not converted to this unique metabolite. The present study revealed that the above metabolite is also excreted as one of the major metabolites in th...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1969/08/25, Vol.17(8), pp.1629-1635 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | TATSUMI, KIYOSHI YOSHIHARA, SHINICHI YAMATO, CHIYUKI YOSHIMURA, HIDETOSHI TSUKAMOTO, HISAO |
| description | In our previous papers, it was shown that phenacetylurea administered to rabbits is metabolized to 3-methoxy-4-hydroxyphenacetylurea, but in mice it is not converted to this unique metabolite. The present study revealed that the above metabolite is also excreted as one of the major metabolites in the urine of guinea pigs and a human after doses of phenacetylurea, as well as rabbits, whereas rats apparently do not follow to this pathway. Although in these species of animals and in a human the metabolic patterns of phenacetylurea were somewhat different each other, the drug was metabolized by two main pathways, hydroxylation of aromatic ring and hydrolysis of ureide group in all species examined. The identification and determination of the metabolites in animal species were facilitated by use of 14C-labeled phenacetylurea. |
| doi_str_mv | 10.1248/cpb.17.1629 |
| format | Article |
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Although in these species of animals and in a human the metabolic patterns of phenacetylurea were somewhat different each other, the drug was metabolized by two main pathways, hydroxylation of aromatic ring and hydrolysis of ureide group in all species examined. The identification and determination of the metabolites in animal species were facilitated by use of 14C-labeled phenacetylurea.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.17.1629</identifier><identifier>PMID: 5348890</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Anticonvulsants - metabolism ; Anticonvulsants - pharmacology ; Anticonvulsants - urine ; Chromatography ; Guinea Pigs ; Humans ; Liver - analysis ; Rabbits ; Radioactivity ; Rats ; Urine - analysis</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1969/08/25, Vol.17(8), pp.1629-1635</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 1969</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4929-62e19375f23daa1210b969076f2232edff7b84e08da1ad4f5b7a330ce46ac15b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,4012,27906,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5348890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TATSUMI, KIYOSHI</creatorcontrib><creatorcontrib>YOSHIHARA, SHINICHI</creatorcontrib><creatorcontrib>YAMATO, CHIYUKI</creatorcontrib><creatorcontrib>YOSHIMURA, HIDETOSHI</creatorcontrib><creatorcontrib>TSUKAMOTO, HISAO</creatorcontrib><title>Metabolism of Drugs. 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The identification and determination of the metabolites in animal species were facilitated by use of 14C-labeled phenacetylurea.</description><subject>Animals</subject><subject>Anticonvulsants - metabolism</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants - urine</subject><subject>Chromatography</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Liver - analysis</subject><subject>Rabbits</subject><subject>Radioactivity</subject><subject>Rats</subject><subject>Urine - analysis</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLxDAURoMoOj5WroWC4EZa82rSLGXGF4wP8IG7kKY32qHTjkm78N-bYUZFN7mB79zD5UPokOCMUF6c2UWZEZkRQdUGGhHGZZpTyjbRCGOsUsoE20G7IcwwpjmWbBtt54wXhcIjdHcLvSm7pg7zpHPJxA9vIUumrzcvWfK4AFtDSCa1c-ChtfEfmb8bD-_QGgv9ZzN4MPtoy5kmwMF67qHny4un8XU6vb-6GZ9PU8sVVamgQBSTuaOsMoZQgkslFJbCxbspVM7JsuCAi8oQU3GXl9Iwhi1wYSzJS7aHTlbehe8-Bgi9ntfBQtOYFroh6IJThYUQETz-B866wbfxNk14riTDhcSROl1R1ncheHB64eu58Z-aYL3sWMeONZF62XGkj9bOoZxD9cOuS435ZJXPQm_e4Cc3vq9tA0sXUXmx9H0_UfsbvxuvoWVfQnqNfg</recordid><startdate>1969</startdate><enddate>1969</enddate><creator>TATSUMI, KIYOSHI</creator><creator>YOSHIHARA, SHINICHI</creator><creator>YAMATO, CHIYUKI</creator><creator>YOSHIMURA, HIDETOSHI</creator><creator>TSUKAMOTO, HISAO</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1969</creationdate><title>Metabolism of Drugs. 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Species Differences of Metabolism of Phenacetylurea</title><author>TATSUMI, KIYOSHI ; YOSHIHARA, SHINICHI ; YAMATO, CHIYUKI ; YOSHIMURA, HIDETOSHI ; TSUKAMOTO, HISAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4929-62e19375f23daa1210b969076f2232edff7b84e08da1ad4f5b7a330ce46ac15b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Anticonvulsants - metabolism</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants - urine</topic><topic>Chromatography</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Liver - analysis</topic><topic>Rabbits</topic><topic>Radioactivity</topic><topic>Rats</topic><topic>Urine - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TATSUMI, KIYOSHI</creatorcontrib><creatorcontrib>YOSHIHARA, SHINICHI</creatorcontrib><creatorcontrib>YAMATO, CHIYUKI</creatorcontrib><creatorcontrib>YOSHIMURA, HIDETOSHI</creatorcontrib><creatorcontrib>TSUKAMOTO, HISAO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TATSUMI, KIYOSHI</au><au>YOSHIHARA, SHINICHI</au><au>YAMATO, CHIYUKI</au><au>YOSHIMURA, HIDETOSHI</au><au>TSUKAMOTO, HISAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism of Drugs. 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| ispartof | Chemical and Pharmaceutical Bulletin, 1969/08/25, Vol.17(8), pp.1629-1635 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_84290666 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Anticonvulsants - metabolism Anticonvulsants - pharmacology Anticonvulsants - urine Chromatography Guinea Pigs Humans Liver - analysis Rabbits Radioactivity Rats Urine - analysis |
| title | Metabolism of Drugs. LXIV. Species Differences of Metabolism of Phenacetylurea |
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