Studies on glucose synthesis by rat liver and kidney cortex slices
Net glucose production has been studied in liver and kidney cortex slices from normal fasted rats. Only a small amount of net glucose synthesis was observed with individual substrates such as lactate, glycerol, phosphoenol pyruvate, succinate, alanine, aspartate and glutamate. With fructose, an incr...
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| Veröffentlicht in: | Life sciences (1973) 1966-04, Vol.5 (7), p.655-663 |
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| container_title | Life sciences (1973) |
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| creator | Wagle, S.R. Gaskins, R.K. Jacoby, Annette Ashmore, J. |
| description | Net glucose production has been studied in liver and kidney cortex slices from normal fasted rats. Only a small amount of net glucose synthesis was observed with individual substrates such as lactate, glycerol, phosphoenol pyruvate, succinate, alanine, aspartate and glutamate. With fructose, an increase in glucose synthesis was observed with an increase in concentration, but similar results were not obtained with lactate. Further studies with combinations of substrates indicate that net glucose synthesis occurs in the following decreasing order: glutamate, glycerol and pyruvate; glutamate and pyruvate; glutamate, glycerol and lactate. Glucose formation by kidney slices was slightly less than that observed in liver. Both tissues gave a similar response to the various substrates tested. |
| doi_str_mv | 10.1016/0024-3205(66)90297-9 |
| format | Article |
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Only a small amount of net glucose synthesis was observed with individual substrates such as lactate, glycerol, phosphoenol pyruvate, succinate, alanine, aspartate and glutamate. With fructose, an increase in glucose synthesis was observed with an increase in concentration, but similar results were not obtained with lactate. Further studies with combinations of substrates indicate that net glucose synthesis occurs in the following decreasing order: glutamate, glycerol and pyruvate; glutamate and pyruvate; glutamate, glycerol and lactate. Glucose formation by kidney slices was slightly less than that observed in liver. Both tissues gave a similar response to the various substrates tested.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(66)90297-9</identifier><identifier>PMID: 5960202</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Alanine - metabolism ; Animals ; Aspartic Acid - metabolism ; Glucose - biosynthesis ; Glutamates - metabolism ; Glycerol - metabolism ; In Vitro Techniques ; Kidney - metabolism ; Lactates - metabolism ; Liver - metabolism ; Pyruvates - metabolism ; Rats ; Succinates - metabolism</subject><ispartof>Life sciences (1973), 1966-04, Vol.5 (7), p.655-663</ispartof><rights>1966</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-c7bde5a809e39af78b65b642afaed8abd7f91e102e46afd986c09429acd9ba563</citedby><cites>FETCH-LOGICAL-c272t-c7bde5a809e39af78b65b642afaed8abd7f91e102e46afd986c09429acd9ba563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0024320566902979$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5960202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wagle, S.R.</creatorcontrib><creatorcontrib>Gaskins, R.K.</creatorcontrib><creatorcontrib>Jacoby, Annette</creatorcontrib><creatorcontrib>Ashmore, J.</creatorcontrib><title>Studies on glucose synthesis by rat liver and kidney cortex slices</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Net glucose production has been studied in liver and kidney cortex slices from normal fasted rats. Only a small amount of net glucose synthesis was observed with individual substrates such as lactate, glycerol, phosphoenol pyruvate, succinate, alanine, aspartate and glutamate. With fructose, an increase in glucose synthesis was observed with an increase in concentration, but similar results were not obtained with lactate. Further studies with combinations of substrates indicate that net glucose synthesis occurs in the following decreasing order: glutamate, glycerol and pyruvate; glutamate and pyruvate; glutamate, glycerol and lactate. Glucose formation by kidney slices was slightly less than that observed in liver. Both tissues gave a similar response to the various substrates tested.</description><subject>Alanine - metabolism</subject><subject>Animals</subject><subject>Aspartic Acid - metabolism</subject><subject>Glucose - biosynthesis</subject><subject>Glutamates - metabolism</subject><subject>Glycerol - metabolism</subject><subject>In Vitro Techniques</subject><subject>Kidney - metabolism</subject><subject>Lactates - metabolism</subject><subject>Liver - metabolism</subject><subject>Pyruvates - metabolism</subject><subject>Rats</subject><subject>Succinates - metabolism</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0EKqXwBiB5QjAEHMd24gUJKm5SJQZgthz7BAxpAj5JRd6ellYdmc7w33Q-Qo5TdpGyVF0yxkWScSbPlDrXjOs80TtknBa5TpjK0l0y3lr2yQHiB2NMyjwbkZHUinHGx-Tmuet9AKRtQ9_q3rUIFIemewcMSMuBRtvROiwgUtt4-hl8AwN1bezgh2IdHOAh2atsjXC0uRPyenf7Mn1IZk_3j9PrWeJ4zrvE5aUHaQumIdO2yotSyVIJbisLvrClzyudQso4CGUrrwvlmBZcW-d1aaXKJuR03fsV2-8esDPzgA7q2jbQ9mgKwQuphVgaxdroYosYoTJfMcxtHEzKzAqdWXExKy5GKfOHzuhl7GTT35dz8NvQhtVSv1rrsHxyESAadAEaBz5EcJ3xbfh_4Bf3W34W</recordid><startdate>196604</startdate><enddate>196604</enddate><creator>Wagle, S.R.</creator><creator>Gaskins, R.K.</creator><creator>Jacoby, Annette</creator><creator>Ashmore, J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196604</creationdate><title>Studies on glucose synthesis by rat liver and kidney cortex slices</title><author>Wagle, S.R. ; Gaskins, R.K. ; Jacoby, Annette ; Ashmore, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-c7bde5a809e39af78b65b642afaed8abd7f91e102e46afd986c09429acd9ba563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Alanine - metabolism</topic><topic>Animals</topic><topic>Aspartic Acid - metabolism</topic><topic>Glucose - biosynthesis</topic><topic>Glutamates - metabolism</topic><topic>Glycerol - metabolism</topic><topic>In Vitro Techniques</topic><topic>Kidney - metabolism</topic><topic>Lactates - metabolism</topic><topic>Liver - metabolism</topic><topic>Pyruvates - metabolism</topic><topic>Rats</topic><topic>Succinates - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wagle, S.R.</creatorcontrib><creatorcontrib>Gaskins, R.K.</creatorcontrib><creatorcontrib>Jacoby, Annette</creatorcontrib><creatorcontrib>Ashmore, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagle, S.R.</au><au>Gaskins, R.K.</au><au>Jacoby, Annette</au><au>Ashmore, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on glucose synthesis by rat liver and kidney cortex slices</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1966-04</date><risdate>1966</risdate><volume>5</volume><issue>7</issue><spage>655</spage><epage>663</epage><pages>655-663</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Net glucose production has been studied in liver and kidney cortex slices from normal fasted rats. 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| ispartof | Life sciences (1973), 1966-04, Vol.5 (7), p.655-663 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alanine - metabolism Animals Aspartic Acid - metabolism Glucose - biosynthesis Glutamates - metabolism Glycerol - metabolism In Vitro Techniques Kidney - metabolism Lactates - metabolism Liver - metabolism Pyruvates - metabolism Rats Succinates - metabolism |
| title | Studies on glucose synthesis by rat liver and kidney cortex slices |
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