Glucose-6-phosphate dehydrogenase activity in adipose tissue from two types of obese mice during starvation
The activity of the enzyme glucose-6-phosphate dehydrogenase (G6PD) has been studied in congenital obese hyperglycemic (Obob) and gold thioglucose obese mice (GTO) and appropriate controls during periods of starvation. Obob mice show no fall in enzyme activity during starvation, an observation in ke...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1966-12, Vol.15 (12), p.1092-1097 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Anderson, John Hollifield, Guy |
| description | The activity of the enzyme glucose-6-phosphate dehydrogenase (G6PD) has been studied in congenital obese hyperglycemic (Obob) and gold thioglucose obese mice (GTO) and appropriate controls during periods of starvation. Obob mice show no fall in enzyme activity during starvation, an observation in keeping with the fact that the rate of lipogenesis remains high in these animals on starvation. GTO mice show a significant fall in enzyme activity by 24 hours of fasting, the level remaining low thereafter. After an initial fall in enzyme activity at 12 hours, normal Ob control and DBA
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mice show an apparent rise in enzyme activity at 24 hours followed by a secondary fall, and it is theorized that this rise in activity may represent a gluconeogenetic adaptive mechanism to starvation. |
| doi_str_mv | 10.1016/0026-0495(66)90098-9 |
| format | Article |
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2
J
mice show an apparent rise in enzyme activity at 24 hours followed by a secondary fall, and it is theorized that this rise in activity may represent a gluconeogenetic adaptive mechanism to starvation.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(66)90098-9</identifier><identifier>PMID: 5960948</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipose Tissue - enzymology ; Animals ; Gluconeogenesis ; Glucose - pharmacology ; Glucosephosphate Dehydrogenase - metabolism ; Gold - pharmacology ; Hyperglycemia ; Mice ; Obesity - metabolism ; Starvation</subject><ispartof>Metabolism, clinical and experimental, 1966-12, Vol.15 (12), p.1092-1097</ispartof><rights>1966</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-14478e8e8120422c7fd1311188c638f5548b71f8d5c64d27cd6f4e1766ea93fe3</citedby><cites>FETCH-LOGICAL-c272t-14478e8e8120422c7fd1311188c638f5548b71f8d5c64d27cd6f4e1766ea93fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0026049566900989$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5960948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, John</creatorcontrib><creatorcontrib>Hollifield, Guy</creatorcontrib><title>Glucose-6-phosphate dehydrogenase activity in adipose tissue from two types of obese mice during starvation</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The activity of the enzyme glucose-6-phosphate dehydrogenase (G6PD) has been studied in congenital obese hyperglycemic (Obob) and gold thioglucose obese mice (GTO) and appropriate controls during periods of starvation. Obob mice show no fall in enzyme activity during starvation, an observation in keeping with the fact that the rate of lipogenesis remains high in these animals on starvation. GTO mice show a significant fall in enzyme activity by 24 hours of fasting, the level remaining low thereafter. After an initial fall in enzyme activity at 12 hours, normal Ob control and DBA
2
J
mice show an apparent rise in enzyme activity at 24 hours followed by a secondary fall, and it is theorized that this rise in activity may represent a gluconeogenetic adaptive mechanism to starvation.</description><subject>Adipose Tissue - enzymology</subject><subject>Animals</subject><subject>Gluconeogenesis</subject><subject>Glucose - pharmacology</subject><subject>Glucosephosphate Dehydrogenase - metabolism</subject><subject>Gold - pharmacology</subject><subject>Hyperglycemia</subject><subject>Mice</subject><subject>Obesity - metabolism</subject><subject>Starvation</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vGyEQhlGVKHWd_oNW4hSlh02AZYG9VKqs1IkUKZfkjDAMMa132QLrav991rWVYzWHObwfo3kQ-kLJDSVU3BLCREV421wL8a0lpFVV-wEtaFOzSglCztDi3fIRfcr5FyFESiUu0EXTCtJytUC_17vRxgyVqIZtzMPWFMAOtpNL8RV6kwEbW8I-lAmHHhsXhtmNS8h5BOxT7HD5G3GZBsg4ehw3MMtdsHPLmEL_inMxaW9KiP0lOvdml-HzaS_Ry8-759V99fi0flj9eKwsk6xUlHOpYB7KCGfMSu9oTSlVyopa-abhaiOpV66xgjsmrROeA5VCgGlrD_USXR17hxT_jJCL7kK2sNuZHuKYteJMNbIms5EfjTbFnBN4PaTQmTRpSvSBsT4A1AeAWgj9j7Fu59jXU_-46cC9h05QZ_37UYf5yX2ApLMN0FtwIYEt2sXw_wNvSeSMRg</recordid><startdate>196612</startdate><enddate>196612</enddate><creator>Anderson, John</creator><creator>Hollifield, Guy</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196612</creationdate><title>Glucose-6-phosphate dehydrogenase activity in adipose tissue from two types of obese mice during starvation</title><author>Anderson, John ; Hollifield, Guy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-14478e8e8120422c7fd1311188c638f5548b71f8d5c64d27cd6f4e1766ea93fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Adipose Tissue - enzymology</topic><topic>Animals</topic><topic>Gluconeogenesis</topic><topic>Glucose - pharmacology</topic><topic>Glucosephosphate Dehydrogenase - metabolism</topic><topic>Gold - pharmacology</topic><topic>Hyperglycemia</topic><topic>Mice</topic><topic>Obesity - metabolism</topic><topic>Starvation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, John</creatorcontrib><creatorcontrib>Hollifield, Guy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, John</au><au>Hollifield, Guy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucose-6-phosphate dehydrogenase activity in adipose tissue from two types of obese mice during starvation</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1966-12</date><risdate>1966</risdate><volume>15</volume><issue>12</issue><spage>1092</spage><epage>1097</epage><pages>1092-1097</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>The activity of the enzyme glucose-6-phosphate dehydrogenase (G6PD) has been studied in congenital obese hyperglycemic (Obob) and gold thioglucose obese mice (GTO) and appropriate controls during periods of starvation. Obob mice show no fall in enzyme activity during starvation, an observation in keeping with the fact that the rate of lipogenesis remains high in these animals on starvation. GTO mice show a significant fall in enzyme activity by 24 hours of fasting, the level remaining low thereafter. After an initial fall in enzyme activity at 12 hours, normal Ob control and DBA
2
J
mice show an apparent rise in enzyme activity at 24 hours followed by a secondary fall, and it is theorized that this rise in activity may represent a gluconeogenetic adaptive mechanism to starvation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5960948</pmid><doi>10.1016/0026-0495(66)90098-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-0495 |
| ispartof | Metabolism, clinical and experimental, 1966-12, Vol.15 (12), p.1092-1097 |
| issn | 0026-0495 1532-8600 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84285730 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adipose Tissue - enzymology Animals Gluconeogenesis Glucose - pharmacology Glucosephosphate Dehydrogenase - metabolism Gold - pharmacology Hyperglycemia Mice Obesity - metabolism Starvation |
| title | Glucose-6-phosphate dehydrogenase activity in adipose tissue from two types of obese mice during starvation |
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