Effect of dimethyl sulfoxide on cooling rates of unrestrained rats
A total of 170 adult rats were exposed to 1°C, 15°C, and 25°C environments following ip injections of 3 to 6 g per kg of DMSO in saline. Shaved subjects receiving 3 g per kg of DMSO in a 1°C environment cooled to a body temperature of 10°C within 239 min; subjects receiving 6 g per kg of DMSO cooled...
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| Veröffentlicht in: | Cryobiology 1966-05, Vol.2 (6), p.345-350 |
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| container_title | Cryobiology |
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| creator | Panuska, J.A. Malinin, T.I. Mentz, R.J. |
| description | A total of 170 adult rats were exposed to 1°C, 15°C, and 25°C environments following ip injections of 3 to 6 g per kg of DMSO in saline. Shaved subjects receiving 3 g per kg of DMSO in a 1°C environment cooled to a body temperature of 10°C within 239 min; subjects receiving 6 g per kg of DMSO cooled to 10°C in 175 min. Shaved saline controls required 412 min to reach the same temperatures. Unshaved rats in a 1°C environment which were treated with 6 g per kg of DMSO cooled to 10°C within 383 min. Unshaved saline controls failed to become hypothermic.
Shaved subjects injected with 6 g per kg of DMSO in an environment of 15°C gave a mixed response, a few maintaining normothermia, some cooling a few degrees and then rewarming, and 50% cooling to environmental temperatures. All controls remained normothermic. At an environmental temperature of 25°C, DMSO-treated animals dropped 3.6°C and then rewarmed. Control subjects remained normothermic. Each DMSO-treated group, therefore, manifested a significant disturbance of temperature regulation. |
| doi_str_mv | 10.1016/S0011-2240(66)80124-4 |
| format | Article |
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Shaved subjects injected with 6 g per kg of DMSO in an environment of 15°C gave a mixed response, a few maintaining normothermia, some cooling a few degrees and then rewarming, and 50% cooling to environmental temperatures. All controls remained normothermic. At an environmental temperature of 25°C, DMSO-treated animals dropped 3.6°C and then rewarmed. Control subjects remained normothermic. Each DMSO-treated group, therefore, manifested a significant disturbance of temperature regulation.</description><identifier>ISSN: 0011-2240</identifier><identifier>EISSN: 1090-2392</identifier><identifier>DOI: 10.1016/S0011-2240(66)80124-4</identifier><identifier>PMID: 5960778</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Body Temperature ; Dimethyl Sulfoxide - pharmacology ; Hypothermia, Induced ; Injections, Intraperitoneal ; Male ; Rats</subject><ispartof>Cryobiology, 1966-05, Vol.2 (6), p.345-350</ispartof><rights>1966</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c275t-473af549e447d6512cbfce1096c6d6d75a1b891b1ef5d317e3cf2cbc7efbaee53</citedby><cites>FETCH-LOGICAL-c275t-473af549e447d6512cbfce1096c6d6d75a1b891b1ef5d317e3cf2cbc7efbaee53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0011-2240(66)80124-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5960778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panuska, J.A.</creatorcontrib><creatorcontrib>Malinin, T.I.</creatorcontrib><creatorcontrib>Mentz, R.J.</creatorcontrib><title>Effect of dimethyl sulfoxide on cooling rates of unrestrained rats</title><title>Cryobiology</title><addtitle>Cryobiology</addtitle><description>A total of 170 adult rats were exposed to 1°C, 15°C, and 25°C environments following ip injections of 3 to 6 g per kg of DMSO in saline. Shaved subjects receiving 3 g per kg of DMSO in a 1°C environment cooled to a body temperature of 10°C within 239 min; subjects receiving 6 g per kg of DMSO cooled to 10°C in 175 min. Shaved saline controls required 412 min to reach the same temperatures. Unshaved rats in a 1°C environment which were treated with 6 g per kg of DMSO cooled to 10°C within 383 min. Unshaved saline controls failed to become hypothermic.
Shaved subjects injected with 6 g per kg of DMSO in an environment of 15°C gave a mixed response, a few maintaining normothermia, some cooling a few degrees and then rewarming, and 50% cooling to environmental temperatures. All controls remained normothermic. At an environmental temperature of 25°C, DMSO-treated animals dropped 3.6°C and then rewarmed. Control subjects remained normothermic. Each DMSO-treated group, therefore, manifested a significant disturbance of temperature regulation.</description><subject>Animals</subject><subject>Body Temperature</subject><subject>Dimethyl Sulfoxide - pharmacology</subject><subject>Hypothermia, Induced</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Rats</subject><issn>0011-2240</issn><issn>1090-2392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQQC0EKqXwCZVyQnAI2I6X5ISgKotUiQNwthJ7DEZJXOwE0b8naSuunEaaebM9hOYEXxFMxPULxoSklDJ8IcRljgllKTtAU4ILnNKsoIdo-occo5MYPzHGQmZsgia8EFjKfIrultaC7hJvE-Ma6D42dRL72vofZyDxbaK9r137noSygzhifRsgdqF0LZgxG0_RkS3rCGf7OENv98vXxWO6en54WtyuUk0l71Ims9JyVgBj0ghOqK6shuFaoYURRvKSVHlBKgKWm4xIyLQdGC3BViUAz2bofDd3HfxXP9ygGhc11HXZgu-jyhnNKc_oAPIdqIOPMYBV6-CaMmwUwWp0p7bu1ChGCaG27hQb-ub7BX3VgPnr2ssa6je7OgxffjsIKmoHrQbjwuBQGe_-2fALOyB-3w</recordid><startdate>196605</startdate><enddate>196605</enddate><creator>Panuska, J.A.</creator><creator>Malinin, T.I.</creator><creator>Mentz, R.J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196605</creationdate><title>Effect of dimethyl sulfoxide on cooling rates of unrestrained rats</title><author>Panuska, J.A. ; Malinin, T.I. ; Mentz, R.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-473af549e447d6512cbfce1096c6d6d75a1b891b1ef5d317e3cf2cbc7efbaee53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Animals</topic><topic>Body Temperature</topic><topic>Dimethyl Sulfoxide - pharmacology</topic><topic>Hypothermia, Induced</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panuska, J.A.</creatorcontrib><creatorcontrib>Malinin, T.I.</creatorcontrib><creatorcontrib>Mentz, R.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cryobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panuska, J.A.</au><au>Malinin, T.I.</au><au>Mentz, R.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of dimethyl sulfoxide on cooling rates of unrestrained rats</atitle><jtitle>Cryobiology</jtitle><addtitle>Cryobiology</addtitle><date>1966-05</date><risdate>1966</risdate><volume>2</volume><issue>6</issue><spage>345</spage><epage>350</epage><pages>345-350</pages><issn>0011-2240</issn><eissn>1090-2392</eissn><abstract>A total of 170 adult rats were exposed to 1°C, 15°C, and 25°C environments following ip injections of 3 to 6 g per kg of DMSO in saline. Shaved subjects receiving 3 g per kg of DMSO in a 1°C environment cooled to a body temperature of 10°C within 239 min; subjects receiving 6 g per kg of DMSO cooled to 10°C in 175 min. Shaved saline controls required 412 min to reach the same temperatures. Unshaved rats in a 1°C environment which were treated with 6 g per kg of DMSO cooled to 10°C within 383 min. Unshaved saline controls failed to become hypothermic.
Shaved subjects injected with 6 g per kg of DMSO in an environment of 15°C gave a mixed response, a few maintaining normothermia, some cooling a few degrees and then rewarming, and 50% cooling to environmental temperatures. All controls remained normothermic. At an environmental temperature of 25°C, DMSO-treated animals dropped 3.6°C and then rewarmed. Control subjects remained normothermic. Each DMSO-treated group, therefore, manifested a significant disturbance of temperature regulation.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>5960778</pmid><doi>10.1016/S0011-2240(66)80124-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cryobiology, 1966-05, Vol.2 (6), p.345-350 |
| issn | 0011-2240 1090-2392 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Body Temperature Dimethyl Sulfoxide - pharmacology Hypothermia, Induced Injections, Intraperitoneal Male Rats |
| title | Effect of dimethyl sulfoxide on cooling rates of unrestrained rats |
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