Metabolism of a tartrazine analogue by intestinal bacteria
Anaerobic incubation of 1-(4[35S]sulphophenyl)-3-methyl-4-(4-sulphophenylazo)-5-pyrazolonewith Proteus vulgaris or rat-gut contents produces labelled sulphanilic acid and 4-sulphophenylhydrazine. Similar incubation with 4[35S]sulphophenylhydrazine gave little conversion to sulphanilic acid with Prot...
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| Veröffentlicht in: | Food and cosmetics toxicology 1969-01, Vol.7 (4), p.297-299 |
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| creator | Ryan, A.J. Welling, P.G. Roxon, J.J. |
| description | Anaerobic incubation of 1-(4[35S]sulphophenyl)-3-methyl-4-(4-sulphophenylazo)-5-pyrazolonewith Proteus vulgaris or rat-gut contents produces labelled sulphanilic acid and 4-sulphophenylhydrazine. Similar incubation with 4[35S]sulphophenylhydrazine gave little conversion to sulphanilic acid with Proteus but good conversion with gut contents. The results obtained support the view that intestinal microflora are mainly responsible for the metabolism of water-soluble pyrazolone dyes in rats.
L'incubation anaérobie de Proteus vulgaris ou du contenu d'intestins de rats avec du1-(4-[35S]sulfophényl-3-méthyl-4-(4-sulfophénylazo)-5-pyrazolone produit de l'acide sulfanilique et de la 4-sulfophénylhydrazine marqués. L'incubation similaire avec de la 4-[35S]sulfophénylhydrazine n'a donné lieu qu'à une médiocre conversion en acide sulfanilique dans le cas de Proteus, mais à une bonne conversion dans le cas du contenu d'intestin. Les résultats obtenus étayent l'opinion que le métabolisme, chez les rats, des colorants hydrosolubles à base de pyrazolone est assumé principalement par la microflore intestinale.
Anaerobe Inkubation von 1-(4-[35S]Sulfophenyl)-3-methyl-4-(4-sulfophenylazo)-5-pyrazolon mit Proteus vulgaris oder Rattendarminhalt erzeugt markierte Sulfanilinsäure und 4-Sulfophenylhydrazin. Die gleiche Inkubation von 4-[35S]Sulfophenylhydrazin ergab mit Proteus wenig Umwandlung in Sulfanilinsäure, aber gute Umwandlung mit Darminhalt. Die erhaltenen Ergebnisse unterstützen die Ansicht, dass die Darmmikroflora in der Hauptsache für den Stoffwechsel wasserlöslichen Pyrazolonfarbstoffe in Ratten verantwortlich ist. |
| doi_str_mv | 10.1016/S0015-6264(69)80365-2 |
| format | Article |
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L'incubation anaérobie de Proteus vulgaris ou du contenu d'intestins de rats avec du1-(4-[35S]sulfophényl-3-méthyl-4-(4-sulfophénylazo)-5-pyrazolone produit de l'acide sulfanilique et de la 4-sulfophénylhydrazine marqués. L'incubation similaire avec de la 4-[35S]sulfophénylhydrazine n'a donné lieu qu'à une médiocre conversion en acide sulfanilique dans le cas de Proteus, mais à une bonne conversion dans le cas du contenu d'intestin. Les résultats obtenus étayent l'opinion que le métabolisme, chez les rats, des colorants hydrosolubles à base de pyrazolone est assumé principalement par la microflore intestinale.
Anaerobe Inkubation von 1-(4-[35S]Sulfophenyl)-3-methyl-4-(4-sulfophenylazo)-5-pyrazolon mit Proteus vulgaris oder Rattendarminhalt erzeugt markierte Sulfanilinsäure und 4-Sulfophenylhydrazin. Die gleiche Inkubation von 4-[35S]Sulfophenylhydrazin ergab mit Proteus wenig Umwandlung in Sulfanilinsäure, aber gute Umwandlung mit Darminhalt. Die erhaltenen Ergebnisse unterstützen die Ansicht, dass die Darmmikroflora in der Hauptsache für den Stoffwechsel wasserlöslichen Pyrazolonfarbstoffe in Ratten verantwortlich ist.</description><identifier>ISSN: 0015-6264</identifier><identifier>DOI: 10.1016/S0015-6264(69)80365-2</identifier><identifier>PMID: 4898704</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Azo Compounds - metabolism ; Chromatography, Thin Layer ; Coloring Agents - metabolism ; In Vitro Techniques ; Intestines - metabolism ; Intestines - microbiology ; Phenylhydrazines - analysis ; Phenylhydrazines - metabolism ; Proteus - metabolism ; Pyrazoles - metabolism ; Radioisotope Dilution Technique ; Rats ; Sulfonic Acids - analysis ; Sulfur Isotopes</subject><ispartof>Food and cosmetics toxicology, 1969-01, Vol.7 (4), p.297-299</ispartof><rights>1969 Pergamon Press Limited</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-74af2c57488767352017ad9540fb13e37369f4011df0ce1097814da1e267b7c43</citedby><cites>FETCH-LOGICAL-c360t-74af2c57488767352017ad9540fb13e37369f4011df0ce1097814da1e267b7c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4898704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryan, A.J.</creatorcontrib><creatorcontrib>Welling, P.G.</creatorcontrib><creatorcontrib>Roxon, J.J.</creatorcontrib><title>Metabolism of a tartrazine analogue by intestinal bacteria</title><title>Food and cosmetics toxicology</title><addtitle>Food Cosmet Toxicol</addtitle><description>Anaerobic incubation of 1-(4[35S]sulphophenyl)-3-methyl-4-(4-sulphophenylazo)-5-pyrazolonewith Proteus vulgaris or rat-gut contents produces labelled sulphanilic acid and 4-sulphophenylhydrazine. Similar incubation with 4[35S]sulphophenylhydrazine gave little conversion to sulphanilic acid with Proteus but good conversion with gut contents. The results obtained support the view that intestinal microflora are mainly responsible for the metabolism of water-soluble pyrazolone dyes in rats.
L'incubation anaérobie de Proteus vulgaris ou du contenu d'intestins de rats avec du1-(4-[35S]sulfophényl-3-méthyl-4-(4-sulfophénylazo)-5-pyrazolone produit de l'acide sulfanilique et de la 4-sulfophénylhydrazine marqués. L'incubation similaire avec de la 4-[35S]sulfophénylhydrazine n'a donné lieu qu'à une médiocre conversion en acide sulfanilique dans le cas de Proteus, mais à une bonne conversion dans le cas du contenu d'intestin. Les résultats obtenus étayent l'opinion que le métabolisme, chez les rats, des colorants hydrosolubles à base de pyrazolone est assumé principalement par la microflore intestinale.
Anaerobe Inkubation von 1-(4-[35S]Sulfophenyl)-3-methyl-4-(4-sulfophenylazo)-5-pyrazolon mit Proteus vulgaris oder Rattendarminhalt erzeugt markierte Sulfanilinsäure und 4-Sulfophenylhydrazin. Die gleiche Inkubation von 4-[35S]Sulfophenylhydrazin ergab mit Proteus wenig Umwandlung in Sulfanilinsäure, aber gute Umwandlung mit Darminhalt. Die erhaltenen Ergebnisse unterstützen die Ansicht, dass die Darmmikroflora in der Hauptsache für den Stoffwechsel wasserlöslichen Pyrazolonfarbstoffe in Ratten verantwortlich ist.</description><subject>Animals</subject><subject>Azo Compounds - metabolism</subject><subject>Chromatography, Thin Layer</subject><subject>Coloring Agents - metabolism</subject><subject>In Vitro Techniques</subject><subject>Intestines - metabolism</subject><subject>Intestines - microbiology</subject><subject>Phenylhydrazines - analysis</subject><subject>Phenylhydrazines - metabolism</subject><subject>Proteus - metabolism</subject><subject>Pyrazoles - metabolism</subject><subject>Radioisotope Dilution Technique</subject><subject>Rats</subject><subject>Sulfonic Acids - analysis</subject><subject>Sulfur Isotopes</subject><issn>0015-6264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRb0AlVL4hEpZIVgExrFjO2wQqnhJRSyAteU4E2SUR7EdpPL1hLbqltVIc--dxyFkTuGSAhVXrwA0T0Um-LkoLhQwkafZAZnu20fkOIRPgIwyRidkwlWhJPApuX7GaMq-caFN-joxSTQ-evPjOkxMZ5r-Y8CkXCeuixiiGztJaWxE78wJOaxNE_B0V2fk_f7ubfGYLl8enha3y9QyATGV3NSZzSVXSgrJ8gyoNFWRc6hLypBJJoqaA6VVDRYpFFJRXhmKmZCltJzNyNl27sr3X8N4hW5dsNg0psN-CFrxTOYM1GjMt0br-xA81nrlXWv8WlPQf5z0hpP-A6JFoTecdDbm5rsFQ9litU_tII36zVbH8ctvh14H67CzWDmPNuqqd_9s-AWr1HgH</recordid><startdate>19690101</startdate><enddate>19690101</enddate><creator>Ryan, A.J.</creator><creator>Welling, P.G.</creator><creator>Roxon, J.J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690101</creationdate><title>Metabolism of a tartrazine analogue by intestinal bacteria</title><author>Ryan, A.J. ; Welling, P.G. ; Roxon, J.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-74af2c57488767352017ad9540fb13e37369f4011df0ce1097814da1e267b7c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Azo Compounds - metabolism</topic><topic>Chromatography, Thin Layer</topic><topic>Coloring Agents - metabolism</topic><topic>In Vitro Techniques</topic><topic>Intestines - metabolism</topic><topic>Intestines - microbiology</topic><topic>Phenylhydrazines - analysis</topic><topic>Phenylhydrazines - metabolism</topic><topic>Proteus - metabolism</topic><topic>Pyrazoles - metabolism</topic><topic>Radioisotope Dilution Technique</topic><topic>Rats</topic><topic>Sulfonic Acids - analysis</topic><topic>Sulfur Isotopes</topic><toplevel>online_resources</toplevel><creatorcontrib>Ryan, A.J.</creatorcontrib><creatorcontrib>Welling, P.G.</creatorcontrib><creatorcontrib>Roxon, J.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food and cosmetics toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryan, A.J.</au><au>Welling, P.G.</au><au>Roxon, J.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism of a tartrazine analogue by intestinal bacteria</atitle><jtitle>Food and cosmetics toxicology</jtitle><addtitle>Food Cosmet Toxicol</addtitle><date>1969-01-01</date><risdate>1969</risdate><volume>7</volume><issue>4</issue><spage>297</spage><epage>299</epage><pages>297-299</pages><issn>0015-6264</issn><abstract>Anaerobic incubation of 1-(4[35S]sulphophenyl)-3-methyl-4-(4-sulphophenylazo)-5-pyrazolonewith Proteus vulgaris or rat-gut contents produces labelled sulphanilic acid and 4-sulphophenylhydrazine. Similar incubation with 4[35S]sulphophenylhydrazine gave little conversion to sulphanilic acid with Proteus but good conversion with gut contents. The results obtained support the view that intestinal microflora are mainly responsible for the metabolism of water-soluble pyrazolone dyes in rats.
L'incubation anaérobie de Proteus vulgaris ou du contenu d'intestins de rats avec du1-(4-[35S]sulfophényl-3-méthyl-4-(4-sulfophénylazo)-5-pyrazolone produit de l'acide sulfanilique et de la 4-sulfophénylhydrazine marqués. L'incubation similaire avec de la 4-[35S]sulfophénylhydrazine n'a donné lieu qu'à une médiocre conversion en acide sulfanilique dans le cas de Proteus, mais à une bonne conversion dans le cas du contenu d'intestin. Les résultats obtenus étayent l'opinion que le métabolisme, chez les rats, des colorants hydrosolubles à base de pyrazolone est assumé principalement par la microflore intestinale.
Anaerobe Inkubation von 1-(4-[35S]Sulfophenyl)-3-methyl-4-(4-sulfophenylazo)-5-pyrazolon mit Proteus vulgaris oder Rattendarminhalt erzeugt markierte Sulfanilinsäure und 4-Sulfophenylhydrazin. Die gleiche Inkubation von 4-[35S]Sulfophenylhydrazin ergab mit Proteus wenig Umwandlung in Sulfanilinsäure, aber gute Umwandlung mit Darminhalt. Die erhaltenen Ergebnisse unterstützen die Ansicht, dass die Darmmikroflora in der Hauptsache für den Stoffwechsel wasserlöslichen Pyrazolonfarbstoffe in Ratten verantwortlich ist.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>4898704</pmid><doi>10.1016/S0015-6264(69)80365-2</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals Azo Compounds - metabolism Chromatography, Thin Layer Coloring Agents - metabolism In Vitro Techniques Intestines - metabolism Intestines - microbiology Phenylhydrazines - analysis Phenylhydrazines - metabolism Proteus - metabolism Pyrazoles - metabolism Radioisotope Dilution Technique Rats Sulfonic Acids - analysis Sulfur Isotopes |
| title | Metabolism of a tartrazine analogue by intestinal bacteria |
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