Effect of Purines on Epinephrine-induced Lipolysis in Adipose Tissue
The purine bases hypoxanthine, xanthine, guanine, and purine markedly inhibit epinephrine-induced lipolysis in rat adipose tissue, an action previously ascribed only to nucleosides, nucleotides, and nucleic acids. The inhibition by purines and purine conjugates is associated with increased destructi...
Gespeichert in:
| Veröffentlicht in: | The Journal of biological chemistry 1966-10, Vol.241 (20), p.4781-4786 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4786 |
|---|---|
| container_issue | 20 |
| container_start_page | 4781 |
| container_title | The Journal of biological chemistry |
| container_volume | 241 |
| creator | Raben, M S Matsuzaki, F |
| description | The purine bases hypoxanthine, xanthine, guanine, and purine markedly inhibit epinephrine-induced lipolysis in rat adipose
tissue, an action previously ascribed only to nucleosides, nucleotides, and nucleic acids. The inhibition by purines and purine
conjugates is associated with increased destruction of epinephrine. Allopurinol, an inhibitor of xanthine oxidase, prevents
the degradation of epinephrine and prevents or reduces the inhibition of lipolysis.
The stimulatory effect of some purine bases on epinephrine-induced lipolysis is confirmed, and the stimulatory effect is shown
to occur in human adipose tissue and in tissue of hypophysectomized and thyroidectomized rats. |
| doi_str_mv | 10.1016/S0021-9258(18)99713-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_84246059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>84246059</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-f0e1a2c60d03d38914a2b68419751b0c7cf91304c332c093247d84ba1bd3b77a3</originalsourceid><addsrcrecordid>eNo9kF1LwzAUhoMoc05_wiAgiF5Uc5K0SS7HnB8wUHCCd6FNUhvp2tqsyP697TZ2bs55Oe_54EFoCuQeCCQPH4RQiBSN5S3IO6UEsEidoDEQySIWw9cpGh8t5-gihB_SB1cwQiNOpRQxjNHjIs-d2eA6x-9d6ysXcF3hRdNXTTHoyFe2M87ipW_qcht8wL7CM9ur4PDKh9C5S3SWp2VwV4c8QZ9Pi9X8JVq-Pb_OZ8vIMKE2UU4cpNQkxBJmmVTAU5olkoPqX8mIESZXwAg3jFFDFKNcWMmzFDLLMiFSNkE3-71NW_92Lmz02gfjyjKtXN0FLTnlCYlVb4z3RtPWIbQu103r12m71UD0QE_v6OkBjQapd_T0MDc9HOiytbPHqQOuvn-97xf-u_jzrdOZr03h1ppy0JRoLiSwf1R5dS0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84246059</pqid></control><display><type>article</type><title>Effect of Purines on Epinephrine-induced Lipolysis in Adipose Tissue</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Raben, M S ; Matsuzaki, F</creator><creatorcontrib>Raben, M S ; Matsuzaki, F</creatorcontrib><description>The purine bases hypoxanthine, xanthine, guanine, and purine markedly inhibit epinephrine-induced lipolysis in rat adipose
tissue, an action previously ascribed only to nucleosides, nucleotides, and nucleic acids. The inhibition by purines and purine
conjugates is associated with increased destruction of epinephrine. Allopurinol, an inhibitor of xanthine oxidase, prevents
the degradation of epinephrine and prevents or reduces the inhibition of lipolysis.
The stimulatory effect of some purine bases on epinephrine-induced lipolysis is confirmed, and the stimulatory effect is shown
to occur in human adipose tissue and in tissue of hypophysectomized and thyroidectomized rats.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(18)99713-9</identifier><identifier>PMID: 4288751</identifier><language>eng</language><publisher>United States: American Society for Biochemistry and Molecular Biology</publisher><subject>Adenine - pharmacology ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Adrenocorticotropic Hormone - pharmacology ; Animals ; Caffeine - pharmacology ; Enzymes - pharmacology ; Epinephrine - pharmacology ; Fatty Acids - metabolism ; Guanine - pharmacology ; Hypoxanthines - pharmacology ; In Vitro Techniques ; Lipid Metabolism ; Purines - pharmacology ; Rats ; Uric Acid - metabolism ; Xanthines - pharmacology</subject><ispartof>The Journal of biological chemistry, 1966-10, Vol.241 (20), p.4781-4786</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-f0e1a2c60d03d38914a2b68419751b0c7cf91304c332c093247d84ba1bd3b77a3</citedby><cites>FETCH-LOGICAL-c379t-f0e1a2c60d03d38914a2b68419751b0c7cf91304c332c093247d84ba1bd3b77a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4288751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raben, M S</creatorcontrib><creatorcontrib>Matsuzaki, F</creatorcontrib><title>Effect of Purines on Epinephrine-induced Lipolysis in Adipose Tissue</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>The purine bases hypoxanthine, xanthine, guanine, and purine markedly inhibit epinephrine-induced lipolysis in rat adipose
tissue, an action previously ascribed only to nucleosides, nucleotides, and nucleic acids. The inhibition by purines and purine
conjugates is associated with increased destruction of epinephrine. Allopurinol, an inhibitor of xanthine oxidase, prevents
the degradation of epinephrine and prevents or reduces the inhibition of lipolysis.
The stimulatory effect of some purine bases on epinephrine-induced lipolysis is confirmed, and the stimulatory effect is shown
to occur in human adipose tissue and in tissue of hypophysectomized and thyroidectomized rats.</description><subject>Adenine - pharmacology</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Animals</subject><subject>Caffeine - pharmacology</subject><subject>Enzymes - pharmacology</subject><subject>Epinephrine - pharmacology</subject><subject>Fatty Acids - metabolism</subject><subject>Guanine - pharmacology</subject><subject>Hypoxanthines - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Lipid Metabolism</subject><subject>Purines - pharmacology</subject><subject>Rats</subject><subject>Uric Acid - metabolism</subject><subject>Xanthines - pharmacology</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMoc05_wiAgiF5Uc5K0SS7HnB8wUHCCd6FNUhvp2tqsyP697TZ2bs55Oe_54EFoCuQeCCQPH4RQiBSN5S3IO6UEsEidoDEQySIWw9cpGh8t5-gihB_SB1cwQiNOpRQxjNHjIs-d2eA6x-9d6ysXcF3hRdNXTTHoyFe2M87ipW_qcht8wL7CM9ur4PDKh9C5S3SWp2VwV4c8QZ9Pi9X8JVq-Pb_OZ8vIMKE2UU4cpNQkxBJmmVTAU5olkoPqX8mIESZXwAg3jFFDFKNcWMmzFDLLMiFSNkE3-71NW_92Lmz02gfjyjKtXN0FLTnlCYlVb4z3RtPWIbQu103r12m71UD0QE_v6OkBjQapd_T0MDc9HOiytbPHqQOuvn-97xf-u_jzrdOZr03h1ppy0JRoLiSwf1R5dS0</recordid><startdate>19661025</startdate><enddate>19661025</enddate><creator>Raben, M S</creator><creator>Matsuzaki, F</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19661025</creationdate><title>Effect of Purines on Epinephrine-induced Lipolysis in Adipose Tissue</title><author>Raben, M S ; Matsuzaki, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-f0e1a2c60d03d38914a2b68419751b0c7cf91304c332c093247d84ba1bd3b77a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Adenine - pharmacology</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Animals</topic><topic>Caffeine - pharmacology</topic><topic>Enzymes - pharmacology</topic><topic>Epinephrine - pharmacology</topic><topic>Fatty Acids - metabolism</topic><topic>Guanine - pharmacology</topic><topic>Hypoxanthines - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Lipid Metabolism</topic><topic>Purines - pharmacology</topic><topic>Rats</topic><topic>Uric Acid - metabolism</topic><topic>Xanthines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raben, M S</creatorcontrib><creatorcontrib>Matsuzaki, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raben, M S</au><au>Matsuzaki, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Purines on Epinephrine-induced Lipolysis in Adipose Tissue</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1966-10-25</date><risdate>1966</risdate><volume>241</volume><issue>20</issue><spage>4781</spage><epage>4786</epage><pages>4781-4786</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><abstract>The purine bases hypoxanthine, xanthine, guanine, and purine markedly inhibit epinephrine-induced lipolysis in rat adipose
tissue, an action previously ascribed only to nucleosides, nucleotides, and nucleic acids. The inhibition by purines and purine
conjugates is associated with increased destruction of epinephrine. Allopurinol, an inhibitor of xanthine oxidase, prevents
the degradation of epinephrine and prevents or reduces the inhibition of lipolysis.
The stimulatory effect of some purine bases on epinephrine-induced lipolysis is confirmed, and the stimulatory effect is shown
to occur in human adipose tissue and in tissue of hypophysectomized and thyroidectomized rats.</abstract><cop>United States</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>4288751</pmid><doi>10.1016/S0021-9258(18)99713-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9258 |
| ispartof | The Journal of biological chemistry, 1966-10, Vol.241 (20), p.4781-4786 |
| issn | 0021-9258 1083-351X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84246059 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenine - pharmacology Adipose Tissue - drug effects Adipose Tissue - metabolism Adrenocorticotropic Hormone - pharmacology Animals Caffeine - pharmacology Enzymes - pharmacology Epinephrine - pharmacology Fatty Acids - metabolism Guanine - pharmacology Hypoxanthines - pharmacology In Vitro Techniques Lipid Metabolism Purines - pharmacology Rats Uric Acid - metabolism Xanthines - pharmacology |
| title | Effect of Purines on Epinephrine-induced Lipolysis in Adipose Tissue |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A53%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Purines%20on%20Epinephrine-induced%20Lipolysis%20in%20Adipose%20Tissue&rft.jtitle=The%20Journal%20of%20biological%20chemistry&rft.au=Raben,%20M%20S&rft.date=1966-10-25&rft.volume=241&rft.issue=20&rft.spage=4781&rft.epage=4786&rft.pages=4781-4786&rft.issn=0021-9258&rft.eissn=1083-351X&rft_id=info:doi/10.1016/S0021-9258(18)99713-9&rft_dat=%3Cproquest_cross%3E84246059%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84246059&rft_id=info:pmid/4288751&rfr_iscdi=true |