Frameshift mutations resulting in the changes of the same amino acid residue (140) in T4 bacteriophage lysozyme and in vivo codons for Trp, Tyr, Met, Val and Ile
The lysozymes of three new strains of double frameshift mutants of T4 bacteriophage, eJ37 eJD3, eJ200 eJD4 and eJ25 eJD1, were isolated from their respective lysates, and their amino acid sequences were compared with that of the wild-type strain. It was found that Trp 138-Tyr-Asn 140 in wild-type ly...
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| Veröffentlicht in: | Journal of molecular biology 1969-05, Vol.41 (3), p.349-364 |
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| container_title | Journal of molecular biology |
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| creator | Tsugita, Akira Inouye, Masayori Imagawa, Tadashi Nakanishi, Tazumi Okada, Yoshimi Emrich, Joyce Streisinger, George |
| description | The lysozymes of three new strains of double frameshift mutants of T4 bacteriophage,
eJ37
eJD3,
eJ200
eJD4 and
eJ25
eJD1, were isolated from their respective lysates, and their amino acid sequences were compared with that of the wild-type strain. It was found that Trp
138-Tyr-Asn
140 in wild-type lysozyme changes to Met-Val-Tyr in
eJ37
eJD3, Tyr
139-Asn
140 to Cys-Ile-Ile in
eJ200
eJD4 and Asn
140 to Ile-Ile in
eJ25
eJD1. From these results, a new hot spot for frameshift mutations has been found at Asn
140 and
in vivo codons for Trp, Tyr, Met, Val and Ile are thought to be UGG, UAU, AUG and AUA, respectively. Nineteen
in vivo codons out of 64 codons have been identified by these results together with our previous results. |
| doi_str_mv | 10.1016/0022-2836(69)90281-2 |
| format | Article |
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eJ37
eJD3,
eJ200
eJD4 and
eJ25
eJD1, were isolated from their respective lysates, and their amino acid sequences were compared with that of the wild-type strain. It was found that Trp
138-Tyr-Asn
140 in wild-type lysozyme changes to Met-Val-Tyr in
eJ37
eJD3, Tyr
139-Asn
140 to Cys-Ile-Ile in
eJ200
eJD4 and Asn
140 to Ile-Ile in
eJ25
eJD1. From these results, a new hot spot for frameshift mutations has been found at Asn
140 and
in vivo codons for Trp, Tyr, Met, Val and Ile are thought to be UGG, UAU, AUG and AUA, respectively. Nineteen
in vivo codons out of 64 codons have been identified by these results together with our previous results.</description><identifier>ISSN: 0022-2836</identifier><identifier>EISSN: 1089-8638</identifier><identifier>DOI: 10.1016/0022-2836(69)90281-2</identifier><identifier>PMID: 5803289</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Amino Acid Sequence ; Chromatography ; Chymotrypsin ; Coliphages - enzymology ; Genetic Code ; Isoleucine ; Methionine ; Molecular Biology ; Muramidase - biosynthesis ; Mutation ; Trypsin ; Tryptophan ; Tyrosine ; Valine</subject><ispartof>Journal of molecular biology, 1969-05, Vol.41 (3), p.349-364</ispartof><rights>1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-9ab7ce5a4527ac44bfb7c840f176e5ba5d7c48f09c3f2c4e7cdb437865b7ff933</citedby><cites>FETCH-LOGICAL-c357t-9ab7ce5a4527ac44bfb7c840f176e5ba5d7c48f09c3f2c4e7cdb437865b7ff933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-2836(69)90281-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5803289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsugita, Akira</creatorcontrib><creatorcontrib>Inouye, Masayori</creatorcontrib><creatorcontrib>Imagawa, Tadashi</creatorcontrib><creatorcontrib>Nakanishi, Tazumi</creatorcontrib><creatorcontrib>Okada, Yoshimi</creatorcontrib><creatorcontrib>Emrich, Joyce</creatorcontrib><creatorcontrib>Streisinger, George</creatorcontrib><title>Frameshift mutations resulting in the changes of the same amino acid residue (140) in T4 bacteriophage lysozyme and in vivo codons for Trp, Tyr, Met, Val and Ile</title><title>Journal of molecular biology</title><addtitle>J Mol Biol</addtitle><description>The lysozymes of three new strains of double frameshift mutants of T4 bacteriophage,
eJ37
eJD3,
eJ200
eJD4 and
eJ25
eJD1, were isolated from their respective lysates, and their amino acid sequences were compared with that of the wild-type strain. It was found that Trp
138-Tyr-Asn
140 in wild-type lysozyme changes to Met-Val-Tyr in
eJ37
eJD3, Tyr
139-Asn
140 to Cys-Ile-Ile in
eJ200
eJD4 and Asn
140 to Ile-Ile in
eJ25
eJD1. From these results, a new hot spot for frameshift mutations has been found at Asn
140 and
in vivo codons for Trp, Tyr, Met, Val and Ile are thought to be UGG, UAU, AUG and AUA, respectively. Nineteen
in vivo codons out of 64 codons have been identified by these results together with our previous results.</description><subject>Amino Acid Sequence</subject><subject>Chromatography</subject><subject>Chymotrypsin</subject><subject>Coliphages - enzymology</subject><subject>Genetic Code</subject><subject>Isoleucine</subject><subject>Methionine</subject><subject>Molecular Biology</subject><subject>Muramidase - biosynthesis</subject><subject>Mutation</subject><subject>Trypsin</subject><subject>Tryptophan</subject><subject>Tyrosine</subject><subject>Valine</subject><issn>0022-2836</issn><issn>1089-8638</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9q3DAQh0VpSDdp36AFnUoC61T_bMuXQAlNGkjoZdurkKXRroptbSV5Yfs2edPau0uOPYlhvm8GzQ-hj5TcUEKrL4QwVjDJq6uquW4Ik7Rgb9CCEtkUsuLyLVq8Iu_QRUq_CSElF_IcnZeScCabBXq5j7qHtPEu437MOvswJBwhjV32wxr7AecNYLPRwxoSDu5QpsnBuvdDwNp4O_PejoCvqCDXs7MSuNUmQ_Rhu9FrwN0-hb_72RrsDOz8LmAT7LzNhYhXcbvEq31c4mfIS_xLdwfysYP36MzpLsGH03uJft5_W919L55-PDzefX0qDC_rXDS6rQ2UWpSs1kaI1k21FMTRuoKy1aWtjZCONIY7ZgTUxraC17Iq29q5hvNL9Pk4dxvDnxFSVr1PBrpODxDGpKRgnEoiJlAcQRNDShGc2kbf67hXlKg5GTWfXc1nV1WjDskoNmmfTvPHtgf7Kp2imPq3xz5Mn9x5iCoZD4MB6yOYrGzw_1_wD6Elne8</recordid><startdate>19690514</startdate><enddate>19690514</enddate><creator>Tsugita, Akira</creator><creator>Inouye, Masayori</creator><creator>Imagawa, Tadashi</creator><creator>Nakanishi, Tazumi</creator><creator>Okada, Yoshimi</creator><creator>Emrich, Joyce</creator><creator>Streisinger, George</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690514</creationdate><title>Frameshift mutations resulting in the changes of the same amino acid residue (140) in T4 bacteriophage lysozyme and in vivo codons for Trp, Tyr, Met, Val and Ile</title><author>Tsugita, Akira ; Inouye, Masayori ; Imagawa, Tadashi ; Nakanishi, Tazumi ; Okada, Yoshimi ; Emrich, Joyce ; Streisinger, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-9ab7ce5a4527ac44bfb7c840f176e5ba5d7c48f09c3f2c4e7cdb437865b7ff933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Amino Acid Sequence</topic><topic>Chromatography</topic><topic>Chymotrypsin</topic><topic>Coliphages - enzymology</topic><topic>Genetic Code</topic><topic>Isoleucine</topic><topic>Methionine</topic><topic>Molecular Biology</topic><topic>Muramidase - biosynthesis</topic><topic>Mutation</topic><topic>Trypsin</topic><topic>Tryptophan</topic><topic>Tyrosine</topic><topic>Valine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsugita, Akira</creatorcontrib><creatorcontrib>Inouye, Masayori</creatorcontrib><creatorcontrib>Imagawa, Tadashi</creatorcontrib><creatorcontrib>Nakanishi, Tazumi</creatorcontrib><creatorcontrib>Okada, Yoshimi</creatorcontrib><creatorcontrib>Emrich, Joyce</creatorcontrib><creatorcontrib>Streisinger, George</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsugita, Akira</au><au>Inouye, Masayori</au><au>Imagawa, Tadashi</au><au>Nakanishi, Tazumi</au><au>Okada, Yoshimi</au><au>Emrich, Joyce</au><au>Streisinger, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frameshift mutations resulting in the changes of the same amino acid residue (140) in T4 bacteriophage lysozyme and in vivo codons for Trp, Tyr, Met, Val and Ile</atitle><jtitle>Journal of molecular biology</jtitle><addtitle>J Mol Biol</addtitle><date>1969-05-14</date><risdate>1969</risdate><volume>41</volume><issue>3</issue><spage>349</spage><epage>364</epage><pages>349-364</pages><issn>0022-2836</issn><eissn>1089-8638</eissn><abstract>The lysozymes of three new strains of double frameshift mutants of T4 bacteriophage,
eJ37
eJD3,
eJ200
eJD4 and
eJ25
eJD1, were isolated from their respective lysates, and their amino acid sequences were compared with that of the wild-type strain. It was found that Trp
138-Tyr-Asn
140 in wild-type lysozyme changes to Met-Val-Tyr in
eJ37
eJD3, Tyr
139-Asn
140 to Cys-Ile-Ile in
eJ200
eJD4 and Asn
140 to Ile-Ile in
eJ25
eJD1. From these results, a new hot spot for frameshift mutations has been found at Asn
140 and
in vivo codons for Trp, Tyr, Met, Val and Ile are thought to be UGG, UAU, AUG and AUA, respectively. Nineteen
in vivo codons out of 64 codons have been identified by these results together with our previous results.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>5803289</pmid><doi>10.1016/0022-2836(69)90281-2</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2836 |
| ispartof | Journal of molecular biology, 1969-05, Vol.41 (3), p.349-364 |
| issn | 0022-2836 1089-8638 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84231804 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Chromatography Chymotrypsin Coliphages - enzymology Genetic Code Isoleucine Methionine Molecular Biology Muramidase - biosynthesis Mutation Trypsin Tryptophan Tyrosine Valine |
| title | Frameshift mutations resulting in the changes of the same amino acid residue (140) in T4 bacteriophage lysozyme and in vivo codons for Trp, Tyr, Met, Val and Ile |
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