Immunosuppression by compounds which complex with deoxyribonucleic acid

Compounds selected for their ability to bind to DNA, as measured by the displacement of methyl green from its DNA complex, were tested for immunosuppressive activity in the graft vs. host reaction (GVHR). Seven compounds of the nineteen compounds tested showed significant immunosuppressive activity....

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Veröffentlicht in:	Biochemical pharmacology 1969-08, Vol.18 (8), p.1823-1827
Hauptverfasser:	Zeleznick, L.D., Crim, J.A., Gray, G.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacology Alcohols - pharmacology Animals Antibody Formation - drug effects Chloroquine - pharmacology Coloring Agents DNA - metabolism Erythrocytes Female Fishes Immunosuppressive Agents - pharmacology Male Methods Mice Protein Binding Quinacrine - pharmacology Quinolines - pharmacology Sheep Spleen - cytology Splenomegaly Transplantation Immunology - drug effects Transplantation, Homologous
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