Hematologic changes in the D1 trisomy syndrome
A propositus was presented manifesting the clinical picture of the D1 syndrome and demonstrating the chromosomal findings of a D/D translocation "trisomy." The increased level of Hb F usually seen in patients with this syndrome was serially demonstrated in the propositus over the first 9 m...
Gespeichert in:
| Veröffentlicht in: | Pediatrics (Evanston) 1966-09, Vol.38 (3), p.419-429 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 429 |
|---|---|
| container_issue | 3 |
| container_start_page | 419 |
| container_title | Pediatrics (Evanston) |
| container_volume | 38 |
| creator | Walzer, S Gerald, P S Breau, G O'Neill, D Diamond, L K |
| description | A propositus was presented manifesting the clinical picture of the D1 syndrome and demonstrating the chromosomal findings of a D/D translocation "trisomy." The increased level of Hb F usually seen in patients with this syndrome was serially demonstrated in the propositus over the first 9 months of life. In addition, the Hb A2 concentration was found to be significantly decreased during the same period. The hypothesis of maturational retardation was invoked to explain the hemoglobin changes and possibly the leucocytic changes in the usual D1 syndrome patient. |
| doi_str_mv | 10.1542/peds.38.3.419 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_84206573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>84206573</sourcerecordid><originalsourceid>FETCH-LOGICAL-c288t-f09ea181b75b6a1d75581456b13df7fe875d2910ee2e7cb691ff59e7199b504e3</originalsourceid><addsrcrecordid>eNo90DtPwzAUhmELgUopjIxImdgSzvEltkdULkWqxAKzlctxG5RLsdMh_55WrZi-5dE3vIzdI2SoJH_aUR0zYTKRSbQXbI5gTSq5VpdsDiAwlQDqmt3E-AMAUmk-YzNl0QgLc5atqCvGoR02TZVU26LfUEyaPhm3lLxgMoYmDt2UxKmvw9DRLbvyRRvp7rwL9v32-rVcpevP94_l8zqtuDFj6sFSgQZLrcq8wForZVCqvERRe-3JaFVzi0DESVdlbtF7ZUmjtaUCSWLBHk-_uzD87imOrmtiRW1b9DTsozOSQ660OMD0BKswxBjIu11ouiJMDsEd-7hjHyeME-7Q5-Afzsf7sqP6X5-DiD9hrV_-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84206573</pqid></control><display><type>article</type><title>Hematologic changes in the D1 trisomy syndrome</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Walzer, S ; Gerald, P S ; Breau, G ; O'Neill, D ; Diamond, L K</creator><creatorcontrib>Walzer, S ; Gerald, P S ; Breau, G ; O'Neill, D ; Diamond, L K</creatorcontrib><description>A propositus was presented manifesting the clinical picture of the D1 syndrome and demonstrating the chromosomal findings of a D/D translocation "trisomy." The increased level of Hb F usually seen in patients with this syndrome was serially demonstrated in the propositus over the first 9 months of life. In addition, the Hb A2 concentration was found to be significantly decreased during the same period. The hypothesis of maturational retardation was invoked to explain the hemoglobin changes and possibly the leucocytic changes in the usual D1 syndrome patient.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.38.3.419</identifier><identifier>PMID: 5918390</identifier><language>eng</language><publisher>United States</publisher><subject>Female ; Fetal Hemoglobin ; Humans ; Infant, Newborn ; Karyotyping ; Leukocyte Count ; Neutrophils ; Trisomy - blood</subject><ispartof>Pediatrics (Evanston), 1966-09, Vol.38 (3), p.419-429</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c288t-f09ea181b75b6a1d75581456b13df7fe875d2910ee2e7cb691ff59e7199b504e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5918390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walzer, S</creatorcontrib><creatorcontrib>Gerald, P S</creatorcontrib><creatorcontrib>Breau, G</creatorcontrib><creatorcontrib>O'Neill, D</creatorcontrib><creatorcontrib>Diamond, L K</creatorcontrib><title>Hematologic changes in the D1 trisomy syndrome</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>A propositus was presented manifesting the clinical picture of the D1 syndrome and demonstrating the chromosomal findings of a D/D translocation "trisomy." The increased level of Hb F usually seen in patients with this syndrome was serially demonstrated in the propositus over the first 9 months of life. In addition, the Hb A2 concentration was found to be significantly decreased during the same period. The hypothesis of maturational retardation was invoked to explain the hemoglobin changes and possibly the leucocytic changes in the usual D1 syndrome patient.</description><subject>Female</subject><subject>Fetal Hemoglobin</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Karyotyping</subject><subject>Leukocyte Count</subject><subject>Neutrophils</subject><subject>Trisomy - blood</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90DtPwzAUhmELgUopjIxImdgSzvEltkdULkWqxAKzlctxG5RLsdMh_55WrZi-5dE3vIzdI2SoJH_aUR0zYTKRSbQXbI5gTSq5VpdsDiAwlQDqmt3E-AMAUmk-YzNl0QgLc5atqCvGoR02TZVU26LfUEyaPhm3lLxgMoYmDt2UxKmvw9DRLbvyRRvp7rwL9v32-rVcpevP94_l8zqtuDFj6sFSgQZLrcq8wForZVCqvERRe-3JaFVzi0DESVdlbtF7ZUmjtaUCSWLBHk-_uzD87imOrmtiRW1b9DTsozOSQ660OMD0BKswxBjIu11ouiJMDsEd-7hjHyeME-7Q5-Afzsf7sqP6X5-DiD9hrV_-</recordid><startdate>196609</startdate><enddate>196609</enddate><creator>Walzer, S</creator><creator>Gerald, P S</creator><creator>Breau, G</creator><creator>O'Neill, D</creator><creator>Diamond, L K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196609</creationdate><title>Hematologic changes in the D1 trisomy syndrome</title><author>Walzer, S ; Gerald, P S ; Breau, G ; O'Neill, D ; Diamond, L K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-f09ea181b75b6a1d75581456b13df7fe875d2910ee2e7cb691ff59e7199b504e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Female</topic><topic>Fetal Hemoglobin</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Karyotyping</topic><topic>Leukocyte Count</topic><topic>Neutrophils</topic><topic>Trisomy - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walzer, S</creatorcontrib><creatorcontrib>Gerald, P S</creatorcontrib><creatorcontrib>Breau, G</creatorcontrib><creatorcontrib>O'Neill, D</creatorcontrib><creatorcontrib>Diamond, L K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walzer, S</au><au>Gerald, P S</au><au>Breau, G</au><au>O'Neill, D</au><au>Diamond, L K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematologic changes in the D1 trisomy syndrome</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1966-09</date><risdate>1966</risdate><volume>38</volume><issue>3</issue><spage>419</spage><epage>429</epage><pages>419-429</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>A propositus was presented manifesting the clinical picture of the D1 syndrome and demonstrating the chromosomal findings of a D/D translocation "trisomy." The increased level of Hb F usually seen in patients with this syndrome was serially demonstrated in the propositus over the first 9 months of life. In addition, the Hb A2 concentration was found to be significantly decreased during the same period. The hypothesis of maturational retardation was invoked to explain the hemoglobin changes and possibly the leucocytic changes in the usual D1 syndrome patient.</abstract><cop>United States</cop><pmid>5918390</pmid><doi>10.1542/peds.38.3.419</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-4005 |
| ispartof | Pediatrics (Evanston), 1966-09, Vol.38 (3), p.419-429 |
| issn | 0031-4005 1098-4275 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84206573 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Female Fetal Hemoglobin Humans Infant, Newborn Karyotyping Leukocyte Count Neutrophils Trisomy - blood |
| title | Hematologic changes in the D1 trisomy syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T17%3A28%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hematologic%20changes%20in%20the%20D1%20trisomy%20syndrome&rft.jtitle=Pediatrics%20(Evanston)&rft.au=Walzer,%20S&rft.date=1966-09&rft.volume=38&rft.issue=3&rft.spage=419&rft.epage=429&rft.pages=419-429&rft.issn=0031-4005&rft.eissn=1098-4275&rft_id=info:doi/10.1542/peds.38.3.419&rft_dat=%3Cproquest_cross%3E84206573%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84206573&rft_id=info:pmid/5918390&rfr_iscdi=true |