Hydrolysis of 4-Acetamidophenyl 2,2,2-Trichloroethyl Carbonate by Esterolytic Enzymes from Various Sources

Hydrolysis rates were determined for ATC in pH 7.4 phosphate buffer containing human plasma from a number of individuals; human plasma treated and stored in various ways; several Cohn fractions of human plasma; human plasma treated with various esterase inhibitors; and a number of commercially avail...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1969-05, Vol.58 (5), p.557-559
Hauptverfasser:	Dittert, Lewis W., Irwin, George M., Rattie, Elisabeth S., Chong, Clifford W., Swintosky, Joseph V.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-trichloroethyl carbonate (ATC)-hydrolysis 4-Acetamidophenyl 2 4-Acetamidophenyl 2,2,2-trichloroethyl carbonate (ATC)—hydrolysis Acetanilides - metabolism Calcium - pharmacology Carbonates - metabolism Cholinesterase Inhibitors - pharmacology Cholinesterases - pharmacology Enzymes Enzymes, human plasma—ATC hydrolysis Esters - metabolism Ethanol - pharmacology human plasma-ATC hydrolysis Humans Peptide Hydrolases - pharmacology Phosphates - pharmacology Plasma Pseudocholinesterase-ATC esterolytic hydrolysis Time Factors
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