Control of Cholesterol Biosynthesis by a Plasma Apo-lipoprotein

MEVALONIC acid (MVA) is well known as a precursor of cholesterol 1 , and it is also established that squalene is an intermediate in the biosynthesis of cholesterol 2,3 . When liver microsomes plus the cell sap are incubated with 2- 14 C mevalonic acid in air, most of the radioactivity is incorporate...

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Veröffentlicht in:	Nature (London) 1969-02, Vol.221 (5180), p.574-575
Hauptverfasser:	BOYD, GEORGE S, ONAJOBI, FUNMILAYO D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Isotopes Cholesterol - biosynthesis Chromatography, Gel Chromatography, Ion Exchange Chromatography, Thin Layer Humanities and Social Sciences letter Lipoproteins - blood Lipoproteins - pharmacology Liver - metabolism Mevalonic Acid - metabolism Microsomes - metabolism multidisciplinary Rats Science Science (multidisciplinary) Squalene - metabolism
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creator	BOYD, GEORGE S ONAJOBI, FUNMILAYO D
description	MEVALONIC acid (MVA) is well known as a precursor of cholesterol 1 , and it is also established that squalene is an intermediate in the biosynthesis of cholesterol 2,3 . When liver microsomes plus the cell sap are incubated with 2- 14 C mevalonic acid in air, most of the radioactivity is incorporated into cholesterol and very little radioactivity is associated with squalene. Conversely, in anaerobic conditions squalene accumulates 4,5 . We have encountered an interesting situation in which squalene accumulates during cholesterologenesis in aerobic conditions.
doi_str_mv	10.1038/221574b0
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When liver microsomes plus the cell sap are incubated with 2- 14 C mevalonic acid in air, most of the radioactivity is incorporated into cholesterol and very little radioactivity is associated with squalene. Conversely, in anaerobic conditions squalene accumulates 4,5 . We have encountered an interesting situation in which squalene accumulates during cholesterologenesis in aerobic conditions.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/221574b0</identifier><identifier>PMID: 5789314</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Carbon Isotopes ; Cholesterol - biosynthesis ; Chromatography, Gel ; Chromatography, Ion Exchange ; Chromatography, Thin Layer ; Humanities and Social Sciences ; letter ; Lipoproteins - blood ; Lipoproteins - pharmacology ; Liver - metabolism ; Mevalonic Acid - metabolism ; Microsomes - metabolism ; multidisciplinary ; Rats ; Science ; Science (multidisciplinary) ; Squalene - metabolism</subject><ispartof>Nature (London), 1969-02, Vol.221 (5180), p.574-575</ispartof><rights>Springer Nature Limited 1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-2dc43f39ea412c50a5fe309c21ea6d20071bd73b8200d332031f7cd0052f47a3</citedby><cites>FETCH-LOGICAL-c335t-2dc43f39ea412c50a5fe309c21ea6d20071bd73b8200d332031f7cd0052f47a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5789314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOYD, GEORGE S</creatorcontrib><creatorcontrib>ONAJOBI, FUNMILAYO D</creatorcontrib><title>Control of Cholesterol Biosynthesis by a Plasma Apo-lipoprotein</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>MEVALONIC acid (MVA) is well known as a precursor of cholesterol 1 , and it is also established that squalene is an intermediate in the biosynthesis of cholesterol 2,3 . 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subjects	Animals Carbon Isotopes Cholesterol - biosynthesis Chromatography, Gel Chromatography, Ion Exchange Chromatography, Thin Layer Humanities and Social Sciences letter Lipoproteins - blood Lipoproteins - pharmacology Liver - metabolism Mevalonic Acid - metabolism Microsomes - metabolism multidisciplinary Rats Science Science (multidisciplinary) Squalene - metabolism
title	Control of Cholesterol Biosynthesis by a Plasma Apo-lipoprotein
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