Similarities between the pharmacological actions of quipazine and serotonin
Experiments have been carried out to establish possible similarities between the actions of quipazine, 2-(1-Piperazinyl) quinoline maleate, a smooth muscle stimulant, and serotonin. When tested on diverse structures, quipazine was found to elicit effects similar to those of serotonin. Thus, it stimu...
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| Veröffentlicht in: | European journal of pharmacology 1969-01, Vol.6 (3), p.274-280 |
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| creator | Hong, Enrique Sancilio, Lawrence F. Vargas, Roberto Pardo, Efraín G. |
| description | Experiments have been carried out to establish possible similarities between the actions of quipazine, 2-(1-Piperazinyl) quinoline maleate, a smooth muscle stimulant, and serotonin. When tested on diverse structures, quipazine was found to elicit effects similar to those of serotonin. Thus, it stimulated the rat uterus, the rabbit aorta, the guinea pig ileum, the guinea pig trachea, and induced bronchoconstriction in the guinea pig and local edema in the rat. The effects on the uterus, the aorta and the lung were antagonized by methysergide; those on the ileum by morphine and phenoxybenzamine, and the edema in the rat by BOL 148. Previous contact of guinea pig ileum segments with quipazine antagonized the responses to serotonin. Changes of behavior observed in cats after the administration of quipazine were abolished by the previous administration of cyproheptadine. All these findings suggest that quipazine and serotonin may exert their actions through stimulation of the same type of receptors. |
| doi_str_mv | 10.1016/0014-2999(69)90185-X |
| format | Article |
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When tested on diverse structures, quipazine was found to elicit effects similar to those of serotonin. Thus, it stimulated the rat uterus, the rabbit aorta, the guinea pig ileum, the guinea pig trachea, and induced bronchoconstriction in the guinea pig and local edema in the rat. The effects on the uterus, the aorta and the lung were antagonized by methysergide; those on the ileum by morphine and phenoxybenzamine, and the edema in the rat by BOL 148. Previous contact of guinea pig ileum segments with quipazine antagonized the responses to serotonin. Changes of behavior observed in cats after the administration of quipazine were abolished by the previous administration of cyproheptadine. 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When tested on diverse structures, quipazine was found to elicit effects similar to those of serotonin. Thus, it stimulated the rat uterus, the rabbit aorta, the guinea pig ileum, the guinea pig trachea, and induced bronchoconstriction in the guinea pig and local edema in the rat. The effects on the uterus, the aorta and the lung were antagonized by methysergide; those on the ileum by morphine and phenoxybenzamine, and the edema in the rat by BOL 148. Previous contact of guinea pig ileum segments with quipazine antagonized the responses to serotonin. Changes of behavior observed in cats after the administration of quipazine were abolished by the previous administration of cyproheptadine. All these findings suggest that quipazine and serotonin may exert their actions through stimulation of the same type of receptors.</description><subject>2-(1-Piperazinyl)quinoline</subject><subject>Animals</subject><subject>Aorta - drug effects</subject><subject>Behavior, Animal - drug effects</subject><subject>Bronchi - drug effects</subject><subject>Constriction</subject><subject>Cyproheptadine - pharmacology</subject><subject>Edema - chemically induced</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Ileum - drug effects</subject><subject>Lung - drug effects</subject><subject>Lysergic Acid Diethylamide - pharmacology</subject><subject>Methysergide - pharmacology</subject><subject>Morphine - pharmacology</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Phenoxybenzamine - pharmacology</subject><subject>Quinolines - pharmacology</subject><subject>Quinolizines - antagonists & inhibitors</subject><subject>Quipazine maleate</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin like actions</subject><subject>Smooth muscle stimulants</subject><subject>Trachea - drug effects</subject><subject>Uterus - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EKqXwD0DKhGAI3CV2Ei9IqOJLIDHA0M1y7AsYJXGxUxD8elpaMTLd8H7pHsYOEc4QsDgHQJ5mUsqTQp5KwEqksy02xqqUKZSYbbPxn2WX7cX4BgBCZmLERqLCIpc4ZvdPrnOtDm5wFJOahk-iPhleKZm_6tBp41v_4oxuE20G5_uY-CZ5X7i5_nY9Jbq3SaTgB9-7fp_tNLqNdLC5E_Z8ffU8vU0fHm_uppcPqeFQDSkKWQCS5E2eyaYAYbMK6lJrLkhqlIjakq1LS8hryMqsAWlrC9pQWXCRT9jxunYe_PuC4qA6Fw21re7JL6KqOJY8F_nSyNdGE3yMgRo1D67T4UshqBVCteKjVnxUIdUvQjVbxo42_Yu6I_sX2jBb6hdrnZY_fjgKKhpHvSHrAplBWe_-H_gBGoaBWg</recordid><startdate>19690101</startdate><enddate>19690101</enddate><creator>Hong, Enrique</creator><creator>Sancilio, Lawrence F.</creator><creator>Vargas, Roberto</creator><creator>Pardo, Efraín G.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690101</creationdate><title>Similarities between the pharmacological actions of quipazine and serotonin</title><author>Hong, Enrique ; Sancilio, Lawrence F. ; Vargas, Roberto ; Pardo, Efraín G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-159601e94f329f605d280b7aa45e9a1911adedb7de14b0272f09dbd0ace76453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>2-(1-Piperazinyl)quinoline</topic><topic>Animals</topic><topic>Aorta - drug effects</topic><topic>Behavior, Animal - drug effects</topic><topic>Bronchi - drug effects</topic><topic>Constriction</topic><topic>Cyproheptadine - pharmacology</topic><topic>Edema - chemically induced</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Ileum - drug effects</topic><topic>Lung - drug effects</topic><topic>Lysergic Acid Diethylamide - pharmacology</topic><topic>Methysergide - pharmacology</topic><topic>Morphine - pharmacology</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Phenoxybenzamine - pharmacology</topic><topic>Quinolines - pharmacology</topic><topic>Quinolizines - antagonists & inhibitors</topic><topic>Quipazine maleate</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin like actions</topic><topic>Smooth muscle stimulants</topic><topic>Trachea - drug effects</topic><topic>Uterus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Enrique</creatorcontrib><creatorcontrib>Sancilio, Lawrence F.</creatorcontrib><creatorcontrib>Vargas, Roberto</creatorcontrib><creatorcontrib>Pardo, Efraín G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Enrique</au><au>Sancilio, Lawrence F.</au><au>Vargas, Roberto</au><au>Pardo, Efraín G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Similarities between the pharmacological actions of quipazine and serotonin</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1969-01-01</date><risdate>1969</risdate><volume>6</volume><issue>3</issue><spage>274</spage><epage>280</epage><pages>274-280</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Experiments have been carried out to establish possible similarities between the actions of quipazine, 2-(1-Piperazinyl) quinoline maleate, a smooth muscle stimulant, and serotonin. When tested on diverse structures, quipazine was found to elicit effects similar to those of serotonin. Thus, it stimulated the rat uterus, the rabbit aorta, the guinea pig ileum, the guinea pig trachea, and induced bronchoconstriction in the guinea pig and local edema in the rat. The effects on the uterus, the aorta and the lung were antagonized by methysergide; those on the ileum by morphine and phenoxybenzamine, and the edema in the rat by BOL 148. Previous contact of guinea pig ileum segments with quipazine antagonized the responses to serotonin. Changes of behavior observed in cats after the administration of quipazine were abolished by the previous administration of cyproheptadine. All these findings suggest that quipazine and serotonin may exert their actions through stimulation of the same type of receptors.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>5816391</pmid><doi>10.1016/0014-2999(69)90185-X</doi><tpages>7</tpages></addata></record> |
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| subjects | 2-(1-Piperazinyl)quinoline Animals Aorta - drug effects Behavior, Animal - drug effects Bronchi - drug effects Constriction Cyproheptadine - pharmacology Edema - chemically induced Female Guinea Pigs Ileum - drug effects Lung - drug effects Lysergic Acid Diethylamide - pharmacology Methysergide - pharmacology Morphine - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Phenoxybenzamine - pharmacology Quinolines - pharmacology Quinolizines - antagonists & inhibitors Quipazine maleate Rabbits Rats Serotonin - pharmacology Serotonin like actions Smooth muscle stimulants Trachea - drug effects Uterus - drug effects |
| title | Similarities between the pharmacological actions of quipazine and serotonin |
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