A New Test for the Presumptive Diagnosis of Neoplastic Disease. Further Investigations of Cholinesterase in Plasma, Whole Blood and Blood Cells on Cancer of the Lung, Extrapulmonary Tumors and Tuberculosis
Cholinesterase activity in plasma, in whole blood and blood cells was determined in 103 adult patients suffering from cancer and 42 adult patients suffering from pulmonary tuberculosis. These are classified as follows: 32 men with cancer of the lung and 22 men with extrapulmonary cancer; 53 women pa...
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| Veröffentlicht in: | Chest 1966-05, Vol.49 (5), p.449-458 |
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| creator | VACCAREZZA, JORGE RAÚL WILLSON, JUAN A. BOCHI, ADOLFO A. |
| description | Cholinesterase activity in plasma, in whole blood and blood cells was determined in 103 adult patients suffering from cancer and 42 adult patients suffering from pulmonary tuberculosis. These are classified as follows: 32 men with cancer of the lung and 22 men with extrapulmonary cancer; 53 women patients suffering from malignant tumors of various organs and 42 women suffering from tuberculosis. Twenty-three men and 20 women, all apparently in good health, were used as controls.
Plasma cholinesterase activity was found to be noticeably decreased in cancer of the lung. The difference when compared with the controls was statistically highly significant (P |
| doi_str_mv | 10.1378/chest.49.5.449 |
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Plasma cholinesterase activity was found to be noticeably decreased in cancer of the lung. The difference when compared with the controls was statistically highly significant (P<0.001). Values lower than the lowest of the normal limits were found in 82.8 per cent of cases. As regards globular cholinesterase activity this was also found to be intensely decreased (P<0.001). The values were lower than the normal limits in 93.9 per cent of the cases studied. In none of the patients were both values normal.
The decrease in whole blood was also statistically highly significant (P<0.001). The values in all patients were found to be lower than the normal limits.
In extrapulmonary cancer the cholinesterase activity in plasma, blood cells and whole blood all showed the same pronounced decrease (P<0.001). The values were lower than normal in all these patients and in all the fractions studied.
Statistically significant decreases (P<0.001) in plasma, whole blood and blood cells were found in the 53 women patients suffering from cancer of different organs. In only one case, i.e., 1.9 per cent, were values found that were higher than the lower normal limit in all determinations (plasma, whole blood and blood cells).
Three patients suffering from malignant lymphogranulomatosis also showed decreased values in all fractions.
As regards the 42 tuberculous patients, a statistically highly significant decrease (P<0.001) was found in the plasma fraction, but this was not so pronounced as in the cancer cases. On the other hand, no statistically significant changes were found in the globular fraction. This dissociation is valuable for differential diagnosis between tuberculosis and cancer of the lung, as in cancer both fractions are decreased.
On the basis of these original findings, we consider that the test of cholinesterase activity in its different fractions, proposed by us, is of value in the presumptive diagnosis of cancer of lung and cancer of other localizations. It is considered necessary that determinations of plasma, whole blood and blood cells be made in order to discount the generally reduced percentage of normal values present in some of these fractions, and also as a new element for the differential diagnosis between lung cancer and tuberculosis.]]></description><identifier>ISSN: 0096-0217</identifier><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 2589-3890</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.49.5.449</identifier><identifier>PMID: 5935882</identifier><language>eng</language><publisher>United States: American College of Chest Physicians</publisher><subject>Adult ; Cholinesterases - metabolism ; Enzymes - blood ; Hodgkin Disease - metabolism ; Humans ; Lung Neoplasms - diagnosis ; Male ; Neoplasms - diagnosis ; Tuberculosis, Pulmonary - metabolism</subject><ispartof>Chest, 1966-05, Vol.49 (5), p.449-458</ispartof><rights>1966 The American College of Chest Physicians</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-585a6eefa19e5972dadc661215528cb147101e11e0eeef0989e917f1466a7d743</citedby><cites>FETCH-LOGICAL-c378t-585a6eefa19e5972dadc661215528cb147101e11e0eeef0989e917f1466a7d743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5935882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VACCAREZZA, JORGE RAÚL</creatorcontrib><creatorcontrib>WILLSON, JUAN A.</creatorcontrib><creatorcontrib>BOCHI, ADOLFO A.</creatorcontrib><title>A New Test for the Presumptive Diagnosis of Neoplastic Disease. Further Investigations of Cholinesterase in Plasma, Whole Blood and Blood Cells on Cancer of the Lung, Extrapulmonary Tumors and Tuberculosis</title><title>Chest</title><addtitle>Dis Chest</addtitle><description><![CDATA[Cholinesterase activity in plasma, in whole blood and blood cells was determined in 103 adult patients suffering from cancer and 42 adult patients suffering from pulmonary tuberculosis. These are classified as follows: 32 men with cancer of the lung and 22 men with extrapulmonary cancer; 53 women patients suffering from malignant tumors of various organs and 42 women suffering from tuberculosis. Twenty-three men and 20 women, all apparently in good health, were used as controls.
Plasma cholinesterase activity was found to be noticeably decreased in cancer of the lung. The difference when compared with the controls was statistically highly significant (P<0.001). Values lower than the lowest of the normal limits were found in 82.8 per cent of cases. As regards globular cholinesterase activity this was also found to be intensely decreased (P<0.001). The values were lower than the normal limits in 93.9 per cent of the cases studied. In none of the patients were both values normal.
The decrease in whole blood was also statistically highly significant (P<0.001). The values in all patients were found to be lower than the normal limits.
In extrapulmonary cancer the cholinesterase activity in plasma, blood cells and whole blood all showed the same pronounced decrease (P<0.001). The values were lower than normal in all these patients and in all the fractions studied.
Statistically significant decreases (P<0.001) in plasma, whole blood and blood cells were found in the 53 women patients suffering from cancer of different organs. In only one case, i.e., 1.9 per cent, were values found that were higher than the lower normal limit in all determinations (plasma, whole blood and blood cells).
Three patients suffering from malignant lymphogranulomatosis also showed decreased values in all fractions.
As regards the 42 tuberculous patients, a statistically highly significant decrease (P<0.001) was found in the plasma fraction, but this was not so pronounced as in the cancer cases. On the other hand, no statistically significant changes were found in the globular fraction. This dissociation is valuable for differential diagnosis between tuberculosis and cancer of the lung, as in cancer both fractions are decreased.
On the basis of these original findings, we consider that the test of cholinesterase activity in its different fractions, proposed by us, is of value in the presumptive diagnosis of cancer of lung and cancer of other localizations. It is considered necessary that determinations of plasma, whole blood and blood cells be made in order to discount the generally reduced percentage of normal values present in some of these fractions, and also as a new element for the differential diagnosis between lung cancer and tuberculosis.]]></description><subject>Adult</subject><subject>Cholinesterases - metabolism</subject><subject>Enzymes - blood</subject><subject>Hodgkin Disease - metabolism</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Male</subject><subject>Neoplasms - diagnosis</subject><subject>Tuberculosis, Pulmonary - metabolism</subject><issn>0096-0217</issn><issn>0012-3692</issn><issn>2589-3890</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhSMEKkNhyw7JK1adYGfiJF6W0EKlEXQxiKXlcW4mrhw72PEUHpJ34s6PgA0rW_Y5n869J8teM5qzVd280wPEOS9FzvOyFE-yRcEbsVw1gj7NFpSKakkLVj_PXsT4QCnnVV1eZBdcrHjTFIvs1zX5DI9kgxDS-0DmAch9gJjGaTZ7IB-M2jkfTSS-R6WfrIqz0fgeQUXIyW0K6Ankzu2RYXZqNt4d1e3grXH4CAGVxDhyj-ZRXZFv-APkvfW-I8p151sL1qLRkVY5jUREHNKsk9tdkZsfc1BTsqN3KvwkmzT6EI_mTdpC0MkeQr7MnvXKRnh1Pi-zr7c3m_bTcv3l4117vV5qXNm85A1XFUCvmAAu6qJTna4qVjDOi0ZvWVkzyoAxoIAqKhoBgtU9K6tK1V1dri6ztyfuFPz3hCPK0USN-ZUDn6JsSlbRmh2E-Umog48xQC-nYEacQDIqD_3JY3-yFJJL7A8Nb87ktB2h-yM_F_YXOJjd8GgCSNyotahenVAPPgWn7D_A5mQA3MfeQJBRG8AFd2jWs-y8-V-W31Q0v0A</recordid><startdate>196605</startdate><enddate>196605</enddate><creator>VACCAREZZA, JORGE RAÚL</creator><creator>WILLSON, JUAN A.</creator><creator>BOCHI, ADOLFO A.</creator><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196605</creationdate><title>A New Test for the Presumptive Diagnosis of Neoplastic Disease. Further Investigations of Cholinesterase in Plasma, Whole Blood and Blood Cells on Cancer of the Lung, Extrapulmonary Tumors and Tuberculosis</title><author>VACCAREZZA, JORGE RAÚL ; WILLSON, JUAN A. ; BOCHI, ADOLFO A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-585a6eefa19e5972dadc661215528cb147101e11e0eeef0989e917f1466a7d743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Adult</topic><topic>Cholinesterases - metabolism</topic><topic>Enzymes - blood</topic><topic>Hodgkin Disease - metabolism</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Male</topic><topic>Neoplasms - diagnosis</topic><topic>Tuberculosis, Pulmonary - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VACCAREZZA, JORGE RAÚL</creatorcontrib><creatorcontrib>WILLSON, JUAN A.</creatorcontrib><creatorcontrib>BOCHI, ADOLFO A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VACCAREZZA, JORGE RAÚL</au><au>WILLSON, JUAN A.</au><au>BOCHI, ADOLFO A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Test for the Presumptive Diagnosis of Neoplastic Disease. Further Investigations of Cholinesterase in Plasma, Whole Blood and Blood Cells on Cancer of the Lung, Extrapulmonary Tumors and Tuberculosis</atitle><jtitle>Chest</jtitle><addtitle>Dis Chest</addtitle><date>1966-05</date><risdate>1966</risdate><volume>49</volume><issue>5</issue><spage>449</spage><epage>458</epage><pages>449-458</pages><issn>0096-0217</issn><issn>0012-3692</issn><eissn>2589-3890</eissn><eissn>1931-3543</eissn><abstract><![CDATA[Cholinesterase activity in plasma, in whole blood and blood cells was determined in 103 adult patients suffering from cancer and 42 adult patients suffering from pulmonary tuberculosis. These are classified as follows: 32 men with cancer of the lung and 22 men with extrapulmonary cancer; 53 women patients suffering from malignant tumors of various organs and 42 women suffering from tuberculosis. Twenty-three men and 20 women, all apparently in good health, were used as controls.
Plasma cholinesterase activity was found to be noticeably decreased in cancer of the lung. The difference when compared with the controls was statistically highly significant (P<0.001). Values lower than the lowest of the normal limits were found in 82.8 per cent of cases. As regards globular cholinesterase activity this was also found to be intensely decreased (P<0.001). The values were lower than the normal limits in 93.9 per cent of the cases studied. In none of the patients were both values normal.
The decrease in whole blood was also statistically highly significant (P<0.001). The values in all patients were found to be lower than the normal limits.
In extrapulmonary cancer the cholinesterase activity in plasma, blood cells and whole blood all showed the same pronounced decrease (P<0.001). The values were lower than normal in all these patients and in all the fractions studied.
Statistically significant decreases (P<0.001) in plasma, whole blood and blood cells were found in the 53 women patients suffering from cancer of different organs. In only one case, i.e., 1.9 per cent, were values found that were higher than the lower normal limit in all determinations (plasma, whole blood and blood cells).
Three patients suffering from malignant lymphogranulomatosis also showed decreased values in all fractions.
As regards the 42 tuberculous patients, a statistically highly significant decrease (P<0.001) was found in the plasma fraction, but this was not so pronounced as in the cancer cases. On the other hand, no statistically significant changes were found in the globular fraction. This dissociation is valuable for differential diagnosis between tuberculosis and cancer of the lung, as in cancer both fractions are decreased.
On the basis of these original findings, we consider that the test of cholinesterase activity in its different fractions, proposed by us, is of value in the presumptive diagnosis of cancer of lung and cancer of other localizations. It is considered necessary that determinations of plasma, whole blood and blood cells be made in order to discount the generally reduced percentage of normal values present in some of these fractions, and also as a new element for the differential diagnosis between lung cancer and tuberculosis.]]></abstract><cop>United States</cop><pub>American College of Chest Physicians</pub><pmid>5935882</pmid><doi>10.1378/chest.49.5.449</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0096-0217 |
| ispartof | Chest, 1966-05, Vol.49 (5), p.449-458 |
| issn | 0096-0217 0012-3692 2589-3890 1931-3543 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Cholinesterases - metabolism Enzymes - blood Hodgkin Disease - metabolism Humans Lung Neoplasms - diagnosis Male Neoplasms - diagnosis Tuberculosis, Pulmonary - metabolism |
| title | A New Test for the Presumptive Diagnosis of Neoplastic Disease. Further Investigations of Cholinesterase in Plasma, Whole Blood and Blood Cells on Cancer of the Lung, Extrapulmonary Tumors and Tuberculosis |
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