Variations of urinary creatinine and its correlation to excretion of indole metabolites in mental patients
The daily creatinine excretion was found to be quite variable in hospitalized schizophrenic patients and mental defectives. The variability was not related to dietary factors. A strong correlation between the daily output of creatinine and tryptamine was observed under a variety of experimental cond...
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| Veröffentlicht in: | Clinica chimica acta 1966-02, Vol.13 (2), p.228-234 |
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| container_title | Clinica chimica acta |
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| creator | Pscheidt, G.K. Berlet, H.H. Spaide, J. Himwich, H.K. |
| description | The daily creatinine excretion was found to be quite variable in hospitalized schizophrenic patients and mental defectives. The variability was not related to dietary factors. A strong correlation between the daily output of creatinine and tryptamine was observed under a variety of experimental conditions. Weaker, but positive correlations were found between the daily excretion of creatinine and 3-indoleacetic acid or 5-hydroxyindoleacetic acid. The relationship between these findings and psychotic episodes in schizophrenic patients is discussed. It is suggested that expression of urinary constituents per unit weight of creatinine may obscure important metabolic variations in mental patients. |
| doi_str_mv | 10.1016/0009-8981(66)90297-X |
| format | Article |
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The variability was not related to dietary factors. A strong correlation between the daily output of creatinine and tryptamine was observed under a variety of experimental conditions. Weaker, but positive correlations were found between the daily excretion of creatinine and 3-indoleacetic acid or 5-hydroxyindoleacetic acid. The relationship between these findings and psychotic episodes in schizophrenic patients is discussed. It is suggested that expression of urinary constituents per unit weight of creatinine may obscure important metabolic variations in mental patients.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(66)90297-X</identifier><identifier>PMID: 5941740</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Chemistry, Clinical ; Circadian Rhythm ; Creatine - metabolism ; Humans ; Hydroxyindoleacetic Acid - metabolism ; In Vitro Techniques ; Indoleacetic Acids - metabolism ; Intellectual Disability - metabolism ; Male ; Middle Aged ; Schizophrenia - metabolism ; Tryptamines - metabolism ; Urine</subject><ispartof>Clinica chimica acta, 1966-02, Vol.13 (2), p.228-234</ispartof><rights>1966</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d4616e53f43c3d7107d1390c35650156729584217b76cb101934f7130aa9f6993</citedby><cites>FETCH-LOGICAL-c357t-d4616e53f43c3d7107d1390c35650156729584217b76cb101934f7130aa9f6993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(66)90297-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5941740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pscheidt, G.K.</creatorcontrib><creatorcontrib>Berlet, H.H.</creatorcontrib><creatorcontrib>Spaide, J.</creatorcontrib><creatorcontrib>Himwich, H.K.</creatorcontrib><title>Variations of urinary creatinine and its correlation to excretion of indole metabolites in mental patients</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>The daily creatinine excretion was found to be quite variable in hospitalized schizophrenic patients and mental defectives. The variability was not related to dietary factors. A strong correlation between the daily output of creatinine and tryptamine was observed under a variety of experimental conditions. Weaker, but positive correlations were found between the daily excretion of creatinine and 3-indoleacetic acid or 5-hydroxyindoleacetic acid. The relationship between these findings and psychotic episodes in schizophrenic patients is discussed. It is suggested that expression of urinary constituents per unit weight of creatinine may obscure important metabolic variations in mental patients.</description><subject>Chemistry, Clinical</subject><subject>Circadian Rhythm</subject><subject>Creatine - metabolism</subject><subject>Humans</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>In Vitro Techniques</subject><subject>Indoleacetic Acids - metabolism</subject><subject>Intellectual Disability - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Schizophrenia - metabolism</subject><subject>Tryptamines - metabolism</subject><subject>Urine</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUJOoofVpMkmm4sgxS8oeFHpLaTZWUjZ3dQkK_rvTT_w6CmZed93hnkQOqfkhhIqbgkhqqhURa-EuFZkqmSxOEBjWklWMK6mh2j8ZzlGJzGucsmJoCM0KhWnkpMxWn2Y4Exyvo_YN3gIrjfhB9sAudm7HrDpa-xSxNaHAO3WipPH8J092yLHXF_7FnAHySx96xLE3Mpln0yL1zmTf_EUHTWmjXC2fyfo_fHhbfZczF-fXmb388KyUqai5oIKKFnDmWW1pETWlCmSRVESWgo5VWXFp1QupbDLTEIx3kjKiDGqEUqxCbrczV0H_zlATLpz0ULbmh78EHXFaclKXmUj3xlt8DEGaPQ6uC6frynRG8R6w09v-Gkh9BaxXuTYxX7-sOyg_gvtmWb9bqdDPvLLQdDRZgAWahfAJl179_-CX0pRi1A</recordid><startdate>196602</startdate><enddate>196602</enddate><creator>Pscheidt, G.K.</creator><creator>Berlet, H.H.</creator><creator>Spaide, J.</creator><creator>Himwich, H.K.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196602</creationdate><title>Variations of urinary creatinine and its correlation to excretion of indole metabolites in mental patients</title><author>Pscheidt, G.K. ; Berlet, H.H. ; Spaide, J. ; Himwich, H.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d4616e53f43c3d7107d1390c35650156729584217b76cb101934f7130aa9f6993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Chemistry, Clinical</topic><topic>Circadian Rhythm</topic><topic>Creatine - metabolism</topic><topic>Humans</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>In Vitro Techniques</topic><topic>Indoleacetic Acids - metabolism</topic><topic>Intellectual Disability - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Schizophrenia - metabolism</topic><topic>Tryptamines - metabolism</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pscheidt, G.K.</creatorcontrib><creatorcontrib>Berlet, H.H.</creatorcontrib><creatorcontrib>Spaide, J.</creatorcontrib><creatorcontrib>Himwich, H.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pscheidt, G.K.</au><au>Berlet, H.H.</au><au>Spaide, J.</au><au>Himwich, H.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations of urinary creatinine and its correlation to excretion of indole metabolites in mental patients</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1966-02</date><risdate>1966</risdate><volume>13</volume><issue>2</issue><spage>228</spage><epage>234</epage><pages>228-234</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>The daily creatinine excretion was found to be quite variable in hospitalized schizophrenic patients and mental defectives. 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| ispartof | Clinica chimica acta, 1966-02, Vol.13 (2), p.228-234 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Chemistry, Clinical Circadian Rhythm Creatine - metabolism Humans Hydroxyindoleacetic Acid - metabolism In Vitro Techniques Indoleacetic Acids - metabolism Intellectual Disability - metabolism Male Middle Aged Schizophrenia - metabolism Tryptamines - metabolism Urine |
| title | Variations of urinary creatinine and its correlation to excretion of indole metabolites in mental patients |
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