Endotoxin-Induced Regional Circulatory Changes in the Unanesthetized Monkey

Endotoxin in eight unanesthetized monkeys produced a small decrease in cardiac output, a marked fall in blood pressure, and a decrease in total peripheral vascular resistance. The distribution of cardiac output was measured by injecting nuclide-labeled radioactive microspheres (50μ in diameter) into...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Circulation research 1969-06, Vol.24 (6), p.777-786
Hauptverfasser: Wyler, Felix, Forsyth, Ralph P, Nies, Alan S, Neutze, John M, Melmon, Kenneth L
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 786
container_issue 6
container_start_page 777
container_title Circulation research
container_volume 24
creator Wyler, Felix
Forsyth, Ralph P
Nies, Alan S
Neutze, John M
Melmon, Kenneth L
description Endotoxin in eight unanesthetized monkeys produced a small decrease in cardiac output, a marked fall in blood pressure, and a decrease in total peripheral vascular resistance. The distribution of cardiac output was measured by injecting nuclide-labeled radioactive microspheres (50μ in diameter) into the left ventricle, and blood flow and vascular resistance were calculated for each organ. All vascular beds except that of the spleen reacted with variable degrees of vasodilation, and the most pronounced decreases in resistance were observed in the coronary, gastrointestinal, and adrenal vasculature. Cerebral flow was reduced, but flow was maintained in the brain stem and cerebellum. In contrast to studies in other species, both the gastrointestinal tract and the kidneys showed vasodilation and no significant decrease in flow during the early phase of endotoxemia.There is some similar evidence in humans of decreased total systemic peripheral resistance without abnormal myocardial function or pooling of blood during the early phase of endotoxemia. The acute regional circulatory changes we have found appear to indicate that endotoxin either directly or through secondary biochemical reactions initiates and maintains a generalized (except for the spleen) vasodilation that reflex compensatory mechanisms cannot overcome. This vasodilation is particularly critical in preventing maintenance of adequate blood flow to the cerebral hemispheres.
doi_str_mv 10.1161/01.RES.24.6.777
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_84147966</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>84147966</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4142-1f33ae0c5cf5d8d9b0a1e9a50d06b25d55f6fd4a931843c814c71beb2137fc8d3</originalsourceid><addsrcrecordid>eNo9kMtP3DAQh62qCBbac09IOfWWMGM7TnxEq-UhQEi0nC3HdtiUrA12Itj-9RjtitO8fvP6CPmFUCEKPAOsHlZ_KsorUTVN840ssKa85HWD38kCAGTZMAZH5DilfwDIGZWH5JDLLKZ0QW5W3oYpvA--vPZ2Ns4WD-5pCF6PxXKIZh71FOK2WK61f3KpGHwxrV3x6LV3KXvT8D-33AX_7LY_yEGvx-R-7u0JebxY_V1elbf3l9fL89vScOS0xJ4x7cDUpq9ta2UHGp3UNVgQHa1tXfeit1xLhi1npkVuGuxcR5E1vWktOyG_d3NfYnid8xlqMyTjxjHfFOak2rymkUJk4dlOaGJIKbpevcRho-NWIahPfApQZXyKciVUJpI7Tvej527j7Jd-zyvX-a7-FsbJxfQ8zm8uqrXT47RWGTcwwPyiFBJEjsrPFGUfLUl7Dg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84147966</pqid></control><display><type>article</type><title>Endotoxin-Induced Regional Circulatory Changes in the Unanesthetized Monkey</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Wyler, Felix ; Forsyth, Ralph P ; Nies, Alan S ; Neutze, John M ; Melmon, Kenneth L</creator><creatorcontrib>Wyler, Felix ; Forsyth, Ralph P ; Nies, Alan S ; Neutze, John M ; Melmon, Kenneth L</creatorcontrib><description>Endotoxin in eight unanesthetized monkeys produced a small decrease in cardiac output, a marked fall in blood pressure, and a decrease in total peripheral vascular resistance. The distribution of cardiac output was measured by injecting nuclide-labeled radioactive microspheres (50μ in diameter) into the left ventricle, and blood flow and vascular resistance were calculated for each organ. All vascular beds except that of the spleen reacted with variable degrees of vasodilation, and the most pronounced decreases in resistance were observed in the coronary, gastrointestinal, and adrenal vasculature. Cerebral flow was reduced, but flow was maintained in the brain stem and cerebellum. In contrast to studies in other species, both the gastrointestinal tract and the kidneys showed vasodilation and no significant decrease in flow during the early phase of endotoxemia.There is some similar evidence in humans of decreased total systemic peripheral resistance without abnormal myocardial function or pooling of blood during the early phase of endotoxemia. The acute regional circulatory changes we have found appear to indicate that endotoxin either directly or through secondary biochemical reactions initiates and maintains a generalized (except for the spleen) vasodilation that reflex compensatory mechanisms cannot overcome. This vasodilation is particularly critical in preventing maintenance of adequate blood flow to the cerebral hemispheres.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.24.6.777</identifier><identifier>PMID: 4977722</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Animals ; Cardiac Output - drug effects ; Cardiovascular System - drug effects ; Cerebrovascular Circulation - drug effects ; Coronary Vessels - drug effects ; Digestive System - blood supply ; Endotoxins - pharmacology ; Haplorhini ; Regional Blood Flow - drug effects ; Spleen - blood supply ; Vascular Resistance - drug effects</subject><ispartof>Circulation research, 1969-06, Vol.24 (6), p.777-786</ispartof><rights>1969 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4142-1f33ae0c5cf5d8d9b0a1e9a50d06b25d55f6fd4a931843c814c71beb2137fc8d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4977722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wyler, Felix</creatorcontrib><creatorcontrib>Forsyth, Ralph P</creatorcontrib><creatorcontrib>Nies, Alan S</creatorcontrib><creatorcontrib>Neutze, John M</creatorcontrib><creatorcontrib>Melmon, Kenneth L</creatorcontrib><title>Endotoxin-Induced Regional Circulatory Changes in the Unanesthetized Monkey</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>Endotoxin in eight unanesthetized monkeys produced a small decrease in cardiac output, a marked fall in blood pressure, and a decrease in total peripheral vascular resistance. The distribution of cardiac output was measured by injecting nuclide-labeled radioactive microspheres (50μ in diameter) into the left ventricle, and blood flow and vascular resistance were calculated for each organ. All vascular beds except that of the spleen reacted with variable degrees of vasodilation, and the most pronounced decreases in resistance were observed in the coronary, gastrointestinal, and adrenal vasculature. Cerebral flow was reduced, but flow was maintained in the brain stem and cerebellum. In contrast to studies in other species, both the gastrointestinal tract and the kidneys showed vasodilation and no significant decrease in flow during the early phase of endotoxemia.There is some similar evidence in humans of decreased total systemic peripheral resistance without abnormal myocardial function or pooling of blood during the early phase of endotoxemia. The acute regional circulatory changes we have found appear to indicate that endotoxin either directly or through secondary biochemical reactions initiates and maintains a generalized (except for the spleen) vasodilation that reflex compensatory mechanisms cannot overcome. This vasodilation is particularly critical in preventing maintenance of adequate blood flow to the cerebral hemispheres.</description><subject>Animals</subject><subject>Cardiac Output - drug effects</subject><subject>Cardiovascular System - drug effects</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Coronary Vessels - drug effects</subject><subject>Digestive System - blood supply</subject><subject>Endotoxins - pharmacology</subject><subject>Haplorhini</subject><subject>Regional Blood Flow - drug effects</subject><subject>Spleen - blood supply</subject><subject>Vascular Resistance - drug effects</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtP3DAQh62qCBbac09IOfWWMGM7TnxEq-UhQEi0nC3HdtiUrA12Itj-9RjtitO8fvP6CPmFUCEKPAOsHlZ_KsorUTVN840ssKa85HWD38kCAGTZMAZH5DilfwDIGZWH5JDLLKZ0QW5W3oYpvA--vPZ2Ns4WD-5pCF6PxXKIZh71FOK2WK61f3KpGHwxrV3x6LV3KXvT8D-33AX_7LY_yEGvx-R-7u0JebxY_V1elbf3l9fL89vScOS0xJ4x7cDUpq9ta2UHGp3UNVgQHa1tXfeit1xLhi1npkVuGuxcR5E1vWktOyG_d3NfYnid8xlqMyTjxjHfFOak2rymkUJk4dlOaGJIKbpevcRho-NWIahPfApQZXyKciVUJpI7Tvej527j7Jd-zyvX-a7-FsbJxfQ8zm8uqrXT47RWGTcwwPyiFBJEjsrPFGUfLUl7Dg</recordid><startdate>196906</startdate><enddate>196906</enddate><creator>Wyler, Felix</creator><creator>Forsyth, Ralph P</creator><creator>Nies, Alan S</creator><creator>Neutze, John M</creator><creator>Melmon, Kenneth L</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196906</creationdate><title>Endotoxin-Induced Regional Circulatory Changes in the Unanesthetized Monkey</title><author>Wyler, Felix ; Forsyth, Ralph P ; Nies, Alan S ; Neutze, John M ; Melmon, Kenneth L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4142-1f33ae0c5cf5d8d9b0a1e9a50d06b25d55f6fd4a931843c814c71beb2137fc8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Cardiac Output - drug effects</topic><topic>Cardiovascular System - drug effects</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Coronary Vessels - drug effects</topic><topic>Digestive System - blood supply</topic><topic>Endotoxins - pharmacology</topic><topic>Haplorhini</topic><topic>Regional Blood Flow - drug effects</topic><topic>Spleen - blood supply</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wyler, Felix</creatorcontrib><creatorcontrib>Forsyth, Ralph P</creatorcontrib><creatorcontrib>Nies, Alan S</creatorcontrib><creatorcontrib>Neutze, John M</creatorcontrib><creatorcontrib>Melmon, Kenneth L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wyler, Felix</au><au>Forsyth, Ralph P</au><au>Nies, Alan S</au><au>Neutze, John M</au><au>Melmon, Kenneth L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endotoxin-Induced Regional Circulatory Changes in the Unanesthetized Monkey</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1969-06</date><risdate>1969</risdate><volume>24</volume><issue>6</issue><spage>777</spage><epage>786</epage><pages>777-786</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>Endotoxin in eight unanesthetized monkeys produced a small decrease in cardiac output, a marked fall in blood pressure, and a decrease in total peripheral vascular resistance. The distribution of cardiac output was measured by injecting nuclide-labeled radioactive microspheres (50μ in diameter) into the left ventricle, and blood flow and vascular resistance were calculated for each organ. All vascular beds except that of the spleen reacted with variable degrees of vasodilation, and the most pronounced decreases in resistance were observed in the coronary, gastrointestinal, and adrenal vasculature. Cerebral flow was reduced, but flow was maintained in the brain stem and cerebellum. In contrast to studies in other species, both the gastrointestinal tract and the kidneys showed vasodilation and no significant decrease in flow during the early phase of endotoxemia.There is some similar evidence in humans of decreased total systemic peripheral resistance without abnormal myocardial function or pooling of blood during the early phase of endotoxemia. The acute regional circulatory changes we have found appear to indicate that endotoxin either directly or through secondary biochemical reactions initiates and maintains a generalized (except for the spleen) vasodilation that reflex compensatory mechanisms cannot overcome. This vasodilation is particularly critical in preventing maintenance of adequate blood flow to the cerebral hemispheres.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>4977722</pmid><doi>10.1161/01.RES.24.6.777</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0009-7330
ispartof Circulation research, 1969-06, Vol.24 (6), p.777-786
issn 0009-7330
1524-4571
language eng
recordid cdi_proquest_miscellaneous_84147966
source MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals
subjects Animals
Cardiac Output - drug effects
Cardiovascular System - drug effects
Cerebrovascular Circulation - drug effects
Coronary Vessels - drug effects
Digestive System - blood supply
Endotoxins - pharmacology
Haplorhini
Regional Blood Flow - drug effects
Spleen - blood supply
Vascular Resistance - drug effects
title Endotoxin-Induced Regional Circulatory Changes in the Unanesthetized Monkey
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T02%3A17%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endotoxin-Induced%20Regional%20Circulatory%20Changes%20in%20the%20Unanesthetized%20Monkey&rft.jtitle=Circulation%20research&rft.au=Wyler,%20Felix&rft.date=1969-06&rft.volume=24&rft.issue=6&rft.spage=777&rft.epage=786&rft.pages=777-786&rft.issn=0009-7330&rft.eissn=1524-4571&rft_id=info:doi/10.1161/01.RES.24.6.777&rft_dat=%3Cproquest_cross%3E84147966%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84147966&rft_id=info:pmid/4977722&rfr_iscdi=true