Effective Treatment of Experimental Herpes Simplex Keratitis with New Derivative, 5-Methylamino-2′-Deoxyuridine (MADU)
Summary A recently synthesized compound, 5-methylamino-2′-deoxyuridine (MADU) was shown to be highly active in suppressing infection with herpes simplex virus in vitro and to exert beneficial effect in therapeutic and prophylactic-therapeutic treatment of experimental keratitis in the rabbit eye cau...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-06, Vol.119 (2), p.515-520 |
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| container_end_page | 520 |
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| container_issue | 2 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 119 |
| creator | Nemes, Marjorie M. Hilleman, M. R. |
| description | Summary
A recently synthesized compound, 5-methylamino-2′-deoxyuridine (MADU) was shown to be highly active in suppressing infection with herpes simplex virus in vitro and to exert beneficial effect in therapeutic and prophylactic-therapeutic treatment of experimental keratitis in the rabbit eye caused by herpes simplex virus. The beneficial effect was equal to or only slightly less than that observed in comparative tests with 5-iodo-2′-deoxyuridine (IDU). The low toxicity of MADU for the rabbit eye, the high level of activity, the absence of halogen, and the apparent low level incorporation into the DNA of host cells justify experimental investigations in man in infections in which IDU would normally be employed. The practical and theoretical implications of use of MADU and IDU in the human being are discussed. |
| doi_str_mv | 10.3181/00379727-119-30224 |
| format | Article |
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A recently synthesized compound, 5-methylamino-2′-deoxyuridine (MADU) was shown to be highly active in suppressing infection with herpes simplex virus in vitro and to exert beneficial effect in therapeutic and prophylactic-therapeutic treatment of experimental keratitis in the rabbit eye caused by herpes simplex virus. The beneficial effect was equal to or only slightly less than that observed in comparative tests with 5-iodo-2′-deoxyuridine (IDU). The low toxicity of MADU for the rabbit eye, the high level of activity, the absence of halogen, and the apparent low level incorporation into the DNA of host cells justify experimental investigations in man in infections in which IDU would normally be employed. The practical and theoretical implications of use of MADU and IDU in the human being are discussed.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-119-30224</identifier><identifier>PMID: 14328932</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Antiviral Agents ; Deoxyuridine ; DNA ; Idoxuridine ; Keratitis ; Keratitis, Dendritic ; Keratitis, Herpetic ; Lagomorpha ; Nucleosides ; Old Medline ; Pharmacology ; Rabbits</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1965-06, Vol.119 (2), p.515-520</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-9c064e9d25d779b45d13228477405e7631638f0f29224a11682db372a853190c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14328932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nemes, Marjorie M.</creatorcontrib><creatorcontrib>Hilleman, M. R.</creatorcontrib><title>Effective Treatment of Experimental Herpes Simplex Keratitis with New Derivative, 5-Methylamino-2′-Deoxyuridine (MADU)</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
A recently synthesized compound, 5-methylamino-2′-deoxyuridine (MADU) was shown to be highly active in suppressing infection with herpes simplex virus in vitro and to exert beneficial effect in therapeutic and prophylactic-therapeutic treatment of experimental keratitis in the rabbit eye caused by herpes simplex virus. The beneficial effect was equal to or only slightly less than that observed in comparative tests with 5-iodo-2′-deoxyuridine (IDU). The low toxicity of MADU for the rabbit eye, the high level of activity, the absence of halogen, and the apparent low level incorporation into the DNA of host cells justify experimental investigations in man in infections in which IDU would normally be employed. The practical and theoretical implications of use of MADU and IDU in the human being are discussed.</description><subject>Animals</subject><subject>Antiviral Agents</subject><subject>Deoxyuridine</subject><subject>DNA</subject><subject>Idoxuridine</subject><subject>Keratitis</subject><subject>Keratitis, Dendritic</subject><subject>Keratitis, Herpetic</subject><subject>Lagomorpha</subject><subject>Nucleosides</subject><subject>Old Medline</subject><subject>Pharmacology</subject><subject>Rabbits</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtO3DAUhq2qqAwDL9BF5VXVSjXjW-J4iZgBKm4LYG15kpNilBu2AzM7nolH4kmadKZix-roSN__S_-H0FdGDwXL2IxSobTiijCmiaCcy09owhKREJFq_RlNRoCMxC7aC-GBUpYonn5Bu0wKnmnBJ2i1KEvIo3sCfOvBxhqaiNsSL1YdeDd-tsJn4DsI-MbVXQUrfA7eRhddwM8u3uMreMbzAX6yY80vnJBLiPfrytauaQl_e3klc2hX6967wjWAf1weze9-7qOd0lYBDrZ3iu5OFrfHZ-Ti-vT38dEFyYVkkeicphJ0wZNCKb2UScEE55lUStIEVCpYKrKSllwP8y1jacaLpVDcZolgmuZiir5vejvfPvYQoqldyKGqbANtH0wmmZRCiQHkGzD3bQgeStMNAqxfG0bN6Nv8920G3-af7yH0bdveL2so3iNbwQMw2wDB_gHz0Pa-GdZ-VPkXZ3eILA</recordid><startdate>196506</startdate><enddate>196506</enddate><creator>Nemes, Marjorie M.</creator><creator>Hilleman, M. R.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196506</creationdate><title>Effective Treatment of Experimental Herpes Simplex Keratitis with New Derivative, 5-Methylamino-2′-Deoxyuridine (MADU)</title><author>Nemes, Marjorie M. ; Hilleman, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-9c064e9d25d779b45d13228477405e7631638f0f29224a11682db372a853190c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Animals</topic><topic>Antiviral Agents</topic><topic>Deoxyuridine</topic><topic>DNA</topic><topic>Idoxuridine</topic><topic>Keratitis</topic><topic>Keratitis, Dendritic</topic><topic>Keratitis, Herpetic</topic><topic>Lagomorpha</topic><topic>Nucleosides</topic><topic>Old Medline</topic><topic>Pharmacology</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nemes, Marjorie M.</creatorcontrib><creatorcontrib>Hilleman, M. R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nemes, Marjorie M.</au><au>Hilleman, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effective Treatment of Experimental Herpes Simplex Keratitis with New Derivative, 5-Methylamino-2′-Deoxyuridine (MADU)</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1965-06</date><risdate>1965</risdate><volume>119</volume><issue>2</issue><spage>515</spage><epage>520</epage><pages>515-520</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
A recently synthesized compound, 5-methylamino-2′-deoxyuridine (MADU) was shown to be highly active in suppressing infection with herpes simplex virus in vitro and to exert beneficial effect in therapeutic and prophylactic-therapeutic treatment of experimental keratitis in the rabbit eye caused by herpes simplex virus. The beneficial effect was equal to or only slightly less than that observed in comparative tests with 5-iodo-2′-deoxyuridine (IDU). The low toxicity of MADU for the rabbit eye, the high level of activity, the absence of halogen, and the apparent low level incorporation into the DNA of host cells justify experimental investigations in man in infections in which IDU would normally be employed. The practical and theoretical implications of use of MADU and IDU in the human being are discussed.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>14328932</pmid><doi>10.3181/00379727-119-30224</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1965-06, Vol.119 (2), p.515-520 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antiviral Agents Deoxyuridine DNA Idoxuridine Keratitis Keratitis, Dendritic Keratitis, Herpetic Lagomorpha Nucleosides Old Medline Pharmacology Rabbits |
| title | Effective Treatment of Experimental Herpes Simplex Keratitis with New Derivative, 5-Methylamino-2′-Deoxyuridine (MADU) |
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