Clear cell adenocarcinoma of the uterine cervix: A histological and histochemical study

A case of Mullerian clear cell adenocarcinoma of the uterine cervix occurring in a young woman is presented. A detailed histological and histochemical study of this type of tumour is important so as to separate it from the clear cell tumour of mesonephric origin. The association of Mullerian clear cell adenocarcinoma and other abnormalities of the vagina and cervix with the administration of maternal nonsteroidal oestrogens has been recently stressed in the literature. However, our patient is illustrative of the 30–50% of cases reported to date which have few if any of the associated abnormalities of the genital tract and have no known exposure to nonsteroidal oestrogens.