Successful Transmission of Visna by Intrapulmonary Inoculation
Visna virus was successfully transmitted to susceptible sheep by intrapul-monary injection. Of 5 sheep inoculated within the first 24 hours of life and surviving over 2 weeks, 1 contracted paralytic visna 22 months after inoculation, and the other 4 all had repeatedly elevated cell counts in the cer...
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| Veröffentlicht in: | The Journal of infectious diseases 1965-06, Vol.115 (3), p.217-225 |
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| container_title | The Journal of infectious diseases |
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| creator | GUDNADOTTIR, M PALSSON, P A |
| description | Visna virus was successfully transmitted to susceptible sheep by intrapul-monary injection. Of 5 sheep inoculated within the first 24 hours of life and surviving over 2 weeks, 1 contracted paralytic visna 22 months after inoculation, and the other 4 all had repeatedly elevated cell counts in the cerebrospinal fluid for a period up to 28 months after inoculation. From 2 of these 4 sheep visna virus was isolated from the cerebrospinal fluid. Of 10 sheep inoculated at the age of 5 months 6 have had elevated cell counts in the cerebrospinal fluid, 1 repeatedly. Visna virus was isolated from the cerebrospinal fluid of 2 sheep in this group and from 1 choroid plexus, yet there has been no paralytic case of visna. Neutralizing antibodies against visna virus were found in sera from all the injected sheep. Lung lesions resembling the lesions found in maedi were seen in 3 cases. The relationship of visna virus and the maedi agent is discussed. |
| doi_str_mv | 10.1093/infdis/115.3.217 |
| format | Article |
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Of 5 sheep inoculated within the first 24 hours of life and surviving over 2 weeks, 1 contracted paralytic visna 22 months after inoculation, and the other 4 all had repeatedly elevated cell counts in the cerebrospinal fluid for a period up to 28 months after inoculation. From 2 of these 4 sheep visna virus was isolated from the cerebrospinal fluid. Of 10 sheep inoculated at the age of 5 months 6 have had elevated cell counts in the cerebrospinal fluid, 1 repeatedly. Visna virus was isolated from the cerebrospinal fluid of 2 sheep in this group and from 1 choroid plexus, yet there has been no paralytic case of visna. Neutralizing antibodies against visna virus were found in sera from all the injected sheep. Lung lesions resembling the lesions found in maedi were seen in 3 cases. The relationship of visna virus and the maedi agent is discussed.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/115.3.217</identifier><identifier>PMID: 14331703</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Animals ; Antibodies ; Blood ; Central nervous system ; Central Nervous System Diseases ; Cerebrospinal Fluid ; Choroid plexus ; Inoculation ; Lesions ; Lung Diseases ; Lungs ; Neutralization Tests ; Neutralizing antibodies ; Old Medline ; Pathology ; Sheep ; Sheep Diseases ; Virus Diseases ; Viruses ; Visna ; Visna maedi virus</subject><ispartof>The Journal of infectious diseases, 1965-06, Vol.115 (3), p.217-225</ispartof><rights>Copyright 1965 University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-8186eb3fd3926c0a42574c58c04788589e38ab56336dac539ae87abe800de3fc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30102006$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30102006$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14331703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GUDNADOTTIR, M</creatorcontrib><creatorcontrib>PALSSON, P A</creatorcontrib><title>Successful Transmission of Visna by Intrapulmonary Inoculation</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Visna virus was successfully transmitted to susceptible sheep by intrapul-monary injection. Of 5 sheep inoculated within the first 24 hours of life and surviving over 2 weeks, 1 contracted paralytic visna 22 months after inoculation, and the other 4 all had repeatedly elevated cell counts in the cerebrospinal fluid for a period up to 28 months after inoculation. From 2 of these 4 sheep visna virus was isolated from the cerebrospinal fluid. Of 10 sheep inoculated at the age of 5 months 6 have had elevated cell counts in the cerebrospinal fluid, 1 repeatedly. Visna virus was isolated from the cerebrospinal fluid of 2 sheep in this group and from 1 choroid plexus, yet there has been no paralytic case of visna. Neutralizing antibodies against visna virus were found in sera from all the injected sheep. Lung lesions resembling the lesions found in maedi were seen in 3 cases. The relationship of visna virus and the maedi agent is discussed.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Blood</subject><subject>Central nervous system</subject><subject>Central Nervous System Diseases</subject><subject>Cerebrospinal Fluid</subject><subject>Choroid plexus</subject><subject>Inoculation</subject><subject>Lesions</subject><subject>Lung Diseases</subject><subject>Lungs</subject><subject>Neutralization Tests</subject><subject>Neutralizing antibodies</subject><subject>Old Medline</subject><subject>Pathology</subject><subject>Sheep</subject><subject>Sheep Diseases</subject><subject>Virus Diseases</subject><subject>Viruses</subject><subject>Visna</subject><subject>Visna maedi virus</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtL7EAQRhu5ouNj7-ZKVu4yVqXSj2yEy_hGEfGBuGk6nQ7Em0nG7gT039uSQVdF8Z2vKA5jBwhzhIKOm66umnCMyOc0z1BusBlykqkQSH_YDCDLUlRFsc12QngDgJyE3GLbmBOhBJqxk4fRWhdCPbbJozddWDYhNH2X9HXy3ITOJOVnctUN3qzGdtl3xn-vvR1bM0Rsj23Wpg1ufz132dP52ePiMr25u7ha_LtJLXE-pAqVcCXVFRWZsGDyjMvccmUhl0pxVThSpuSCSFTGciqMU9KUTgFUjmpLu-xourvy_fvowqDjn9a1relcPwatckSVc4ogTKD1fQje1Xrlm2X8WiPob2d6cqajM006OouVw_XtsVy66rewlhSBvxPwFobe_-QECBmAiHk65U0Y3MdPbvx_LSRJri9fXrXIrp_vb_FUI30BsICBrw</recordid><startdate>196506</startdate><enddate>196506</enddate><creator>GUDNADOTTIR, M</creator><creator>PALSSON, P A</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196506</creationdate><title>Successful Transmission of Visna by Intrapulmonary Inoculation</title><author>GUDNADOTTIR, M ; PALSSON, P A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-8186eb3fd3926c0a42574c58c04788589e38ab56336dac539ae87abe800de3fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Blood</topic><topic>Central nervous system</topic><topic>Central Nervous System Diseases</topic><topic>Cerebrospinal Fluid</topic><topic>Choroid plexus</topic><topic>Inoculation</topic><topic>Lesions</topic><topic>Lung Diseases</topic><topic>Lungs</topic><topic>Neutralization Tests</topic><topic>Neutralizing antibodies</topic><topic>Old Medline</topic><topic>Pathology</topic><topic>Sheep</topic><topic>Sheep Diseases</topic><topic>Virus Diseases</topic><topic>Viruses</topic><topic>Visna</topic><topic>Visna maedi virus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GUDNADOTTIR, M</creatorcontrib><creatorcontrib>PALSSON, P A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GUDNADOTTIR, M</au><au>PALSSON, P A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Transmission of Visna by Intrapulmonary Inoculation</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1965-06</date><risdate>1965</risdate><volume>115</volume><issue>3</issue><spage>217</spage><epage>225</epage><pages>217-225</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Visna virus was successfully transmitted to susceptible sheep by intrapul-monary injection. Of 5 sheep inoculated within the first 24 hours of life and surviving over 2 weeks, 1 contracted paralytic visna 22 months after inoculation, and the other 4 all had repeatedly elevated cell counts in the cerebrospinal fluid for a period up to 28 months after inoculation. From 2 of these 4 sheep visna virus was isolated from the cerebrospinal fluid. Of 10 sheep inoculated at the age of 5 months 6 have had elevated cell counts in the cerebrospinal fluid, 1 repeatedly. Visna virus was isolated from the cerebrospinal fluid of 2 sheep in this group and from 1 choroid plexus, yet there has been no paralytic case of visna. Neutralizing antibodies against visna virus were found in sera from all the injected sheep. Lung lesions resembling the lesions found in maedi were seen in 3 cases. The relationship of visna virus and the maedi agent is discussed.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>14331703</pmid><doi>10.1093/infdis/115.3.217</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1965-06, Vol.115 (3), p.217-225 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84118453 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Antibodies Blood Central nervous system Central Nervous System Diseases Cerebrospinal Fluid Choroid plexus Inoculation Lesions Lung Diseases Lungs Neutralization Tests Neutralizing antibodies Old Medline Pathology Sheep Sheep Diseases Virus Diseases Viruses Visna Visna maedi virus |
| title | Successful Transmission of Visna by Intrapulmonary Inoculation |
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