Denervation effects on newt limb regeneration: DNA, RNA, and protein synthesis
Denervation of the regenerating limbs of adult newts results in a time-dependent loss in the capacity to incorporate radioactive precursors of RNA, DNA, and protein in the regenerating tissues, but not in neighboring nonregenerative tissue. The capacity to incorporate radioactive uridine decreases w...
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| Veröffentlicht in: | Developmental biology 1969-04, Vol.19 (4), p.311-320 |
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| container_title | Developmental biology |
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| creator | Dresden, Marc H. |
| description | Denervation of the regenerating limbs of adult newts results in a time-dependent loss in the capacity to incorporate radioactive precursors of RNA, DNA, and protein in the regenerating tissues, but not in neighboring nonregenerative tissue. The capacity to incorporate radioactive uridine decreases within 7 hours after denervation, whereas thymidine and leucine incorporation are not affected until 24 hours after denervation.
The decrease in synthetic capacity of regenerating tissue can be reproduced in
in vitro organ culture.
It is suggested that the nerve may exert a direct control over the synthesis of DNA, RNA, and protein in regenerating tissues. |
| doi_str_mv | 10.1016/0012-1606(69)90044-X |
| format | Article |
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The decrease in synthetic capacity of regenerating tissue can be reproduced in
in vitro organ culture.
It is suggested that the nerve may exert a direct control over the synthesis of DNA, RNA, and protein in regenerating tissues.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/0012-1606(69)90044-X</identifier><identifier>PMID: 5772664</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carbon Isotopes ; Culture Techniques ; Denervation ; DNA - biosynthesis ; Forelimb - innervation ; Forelimb - metabolism ; Injections, Intraperitoneal ; Leucine - metabolism ; Nucleosides - metabolism ; Protein Biosynthesis ; Regeneration ; RNA - biosynthesis ; Spinal Nerves - surgery ; Tritium ; Urodela - anatomy & histology ; Urodela - metabolism</subject><ispartof>Developmental biology, 1969-04, Vol.19 (4), p.311-320</ispartof><rights>1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-c43823fed3f171d05ba0271b0bf3bbf3ef72ce2d1a5374289aff69eba7ec5c013</citedby><cites>FETCH-LOGICAL-c357t-c43823fed3f171d05ba0271b0bf3bbf3ef72ce2d1a5374289aff69eba7ec5c013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0012-1606(69)90044-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5772664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dresden, Marc H.</creatorcontrib><title>Denervation effects on newt limb regeneration: DNA, RNA, and protein synthesis</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>Denervation of the regenerating limbs of adult newts results in a time-dependent loss in the capacity to incorporate radioactive precursors of RNA, DNA, and protein in the regenerating tissues, but not in neighboring nonregenerative tissue. The capacity to incorporate radioactive uridine decreases within 7 hours after denervation, whereas thymidine and leucine incorporation are not affected until 24 hours after denervation.
The decrease in synthetic capacity of regenerating tissue can be reproduced in
in vitro organ culture.
It is suggested that the nerve may exert a direct control over the synthesis of DNA, RNA, and protein in regenerating tissues.</description><subject>Animals</subject><subject>Carbon Isotopes</subject><subject>Culture Techniques</subject><subject>Denervation</subject><subject>DNA - biosynthesis</subject><subject>Forelimb - innervation</subject><subject>Forelimb - metabolism</subject><subject>Injections, Intraperitoneal</subject><subject>Leucine - metabolism</subject><subject>Nucleosides - metabolism</subject><subject>Protein Biosynthesis</subject><subject>Regeneration</subject><subject>RNA - biosynthesis</subject><subject>Spinal Nerves - surgery</subject><subject>Tritium</subject><subject>Urodela - anatomy & histology</subject><subject>Urodela - metabolism</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1LwzAQwIMoc07_A4U8iYLVfLRJ64MwNr9gTBCFvYU0vWika2fSTfbf27qxRx8uF7jf3SU_hE4puaaEihtCKIuoIOJCZJcZIXEczfZQn5IsiRIRz_ZRf4ccoqMQvgghPE15D_USKZkQcR9Nx1CBX-nG1RUGa8E0AbfXCn4aXLp5jj18dMgfcYvH0-EVfu0OXRV44esGXIXDumo-IbhwjA6sLgOcbPMAvT_cv42eosnL4_NoOIkMT2QTmZinjFsouKWSFiTJNWGS5iS3PG8DrGQGWEF1wmXM0kxbKzLItQSTGEL5AJ1v5rYv-F5CaNTcBQNlqSuol0GlMaVM8qwF4w1ofB2CB6sW3s21XytKVKdRdY5U50iJTP1pVLO27Ww7f5nPodg1bb219btNHdpPrhx4FYyDykDhfKtQFbX7f8Ev0-aBog</recordid><startdate>196904</startdate><enddate>196904</enddate><creator>Dresden, Marc H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196904</creationdate><title>Denervation effects on newt limb regeneration: DNA, RNA, and protein synthesis</title><author>Dresden, Marc H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c43823fed3f171d05ba0271b0bf3bbf3ef72ce2d1a5374289aff69eba7ec5c013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Carbon Isotopes</topic><topic>Culture Techniques</topic><topic>Denervation</topic><topic>DNA - biosynthesis</topic><topic>Forelimb - innervation</topic><topic>Forelimb - metabolism</topic><topic>Injections, Intraperitoneal</topic><topic>Leucine - metabolism</topic><topic>Nucleosides - metabolism</topic><topic>Protein Biosynthesis</topic><topic>Regeneration</topic><topic>RNA - biosynthesis</topic><topic>Spinal Nerves - surgery</topic><topic>Tritium</topic><topic>Urodela - anatomy & histology</topic><topic>Urodela - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dresden, Marc H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dresden, Marc H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Denervation effects on newt limb regeneration: DNA, RNA, and protein synthesis</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>1969-04</date><risdate>1969</risdate><volume>19</volume><issue>4</issue><spage>311</spage><epage>320</epage><pages>311-320</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><abstract>Denervation of the regenerating limbs of adult newts results in a time-dependent loss in the capacity to incorporate radioactive precursors of RNA, DNA, and protein in the regenerating tissues, but not in neighboring nonregenerative tissue. The capacity to incorporate radioactive uridine decreases within 7 hours after denervation, whereas thymidine and leucine incorporation are not affected until 24 hours after denervation.
The decrease in synthetic capacity of regenerating tissue can be reproduced in
in vitro organ culture.
It is suggested that the nerve may exert a direct control over the synthesis of DNA, RNA, and protein in regenerating tissues.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5772664</pmid><doi>10.1016/0012-1606(69)90044-X</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1606 |
| ispartof | Developmental biology, 1969-04, Vol.19 (4), p.311-320 |
| issn | 0012-1606 1095-564X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84112739 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Carbon Isotopes Culture Techniques Denervation DNA - biosynthesis Forelimb - innervation Forelimb - metabolism Injections, Intraperitoneal Leucine - metabolism Nucleosides - metabolism Protein Biosynthesis Regeneration RNA - biosynthesis Spinal Nerves - surgery Tritium Urodela - anatomy & histology Urodela - metabolism |
| title | Denervation effects on newt limb regeneration: DNA, RNA, and protein synthesis |
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