Inhibition of Hepatic Alcohol Dehydrogenase by Bilirubin

Inhibition of Hepatic Alcohol Dehydrogenase by Bilirubin

Human bile is capable of inhibiting, in vitro , the action of human and equine liver alcohol dehydrogenase. The effect is attributable mainly to bilirubin conjugates. Sodium deoxycholate had negligible inhibitory ability. Preliminary evidence indicates that the mechanism of this inhibition of alcoho...

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Veröffentlicht in:The Journal of biological chemistry 1966-02, Vol.241 (3), p.669-672
Hauptverfasser: Flitman, R, Worth, Jr, M H
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol Oxidoreductases - metabolism
Animals
Bile - metabolism
Bilirubin - pharmacology
Enzymes
Horses
Humans
In Vitro Techniques
Kernicterus - etiology
Liver - enzymology
Liver Diseases - metabolism
Oxidative Phosphorylation
Pancreatic Diseases - metabolism
Rats
Zinc
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Beschreibung
Zusammenfassung:Human bile is capable of inhibiting, in vitro , the action of human and equine liver alcohol dehydrogenase. The effect is attributable mainly to bilirubin conjugates. Sodium deoxycholate had negligible inhibitory ability. Preliminary evidence indicates that the mechanism of this inhibition of alcohol dehydrogenase is related to the capability of bilirubin for complex formation with the zinc ion. The clinical implication of these findings is discussed.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)96890-0