Treatment with metronidazole of 48 patients with serious anaerobic infections
Forty-eight patients in whom 50 serious anaerobic infections were diagnosed, were treated with metronidazole either orally (33) or rectally (15). Complete recovery occurred in 38 infections, while in 9 there was a satisfactory response, and 3 were considered as treatment failures. Thirteen of the 15...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1977-07, Vol.3 (4), p.347-353 |
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| container_end_page | 353 |
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| container_issue | 4 |
| container_start_page | 347 |
| container_title | Journal of antimicrobial chemotherapy |
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| creator | Giamarellon, H. Kanellakopoulou, K. Pragastis, D. Tagaris, N. Daikos, G. K. |
| description | Forty-eight patients in whom 50 serious anaerobic infections were diagnosed, were treated with metronidazole either orally (33) or rectally (15). Complete recovery occurred in 38 infections, while in 9 there was a satisfactory response, and 3 were considered as treatment failures. Thirteen of the 15 patients treated with suppositories had a complete recovery, while the other patients had a satisfactory response. Serum levels for metronidazole were obtained in 19 patients as well as in 12 volunteers. Similar peak levels, ranging between 10 to 30 mg/l were found after either the oral or rectal route. Sustained high levels were obtained when using the rectal route. |
| doi_str_mv | 10.1093/jac/3.4.347 |
| format | Article |
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K.</creatorcontrib><title>Treatment with metronidazole of 48 patients with serious anaerobic infections</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Forty-eight patients in whom 50 serious anaerobic infections were diagnosed, were treated with metronidazole either orally (33) or rectally (15). Complete recovery occurred in 38 infections, while in 9 there was a satisfactory response, and 3 were considered as treatment failures. Thirteen of the 15 patients treated with suppositories had a complete recovery, while the other patients had a satisfactory response. Serum levels for metronidazole were obtained in 19 patients as well as in 12 volunteers. Similar peak levels, ranging between 10 to 30 mg/l were found after either the oral or rectal route. Sustained high levels were obtained when using the rectal route.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anaerobiosis</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Metronidazole - administration & dosage</subject><subject>Metronidazole - blood</subject><subject>Metronidazole - therapeutic use</subject><subject>Middle Aged</subject><subject>Rectum</subject><subject>Suppositories</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AURgfxVasrty6yciNp553MUuqjSlWECqWbYZLc4NQ86swUH7_eSEpXd3EOH5eD0DnBI4IVG69MPmYjPmI82UMDwiWOKVZkHw0wwyJOuGDH6MT7FcZYCpkeocNUMcrpAD3NHZhQQxOiLxveoxqCaxtbmN-2gqgtI55GaxNsJ_je8OBsu_GRaQy4NrN5ZJsS8mDbxp-ig9JUHs62d4je7m7nk2k8e7l_mFzP4pxREuIylUKwNMszAyCLPKOAM6YMZYoaUxCRSQokMVxJoWgKkuIE4wSowsqUjLEhuux316793IAPurY-h6oyDXS_6ZTjlCRKdOJVL-au9d5BqdfO1sb9aIL1fzvdtdNMc9216-yL7ewmq6HYuX2sDsc9tj7A944a96FlwhKhp4ulflw8T5evYqZv2B-XlHm2</recordid><startdate>197707</startdate><enddate>197707</enddate><creator>Giamarellon, H.</creator><creator>Kanellakopoulou, K.</creator><creator>Pragastis, D.</creator><creator>Tagaris, N.</creator><creator>Daikos, G. 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K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment with metronidazole of 48 patients with serious anaerobic infections</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1977-07</date><risdate>1977</risdate><volume>3</volume><issue>4</issue><spage>347</spage><epage>353</epage><pages>347-353</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>Forty-eight patients in whom 50 serious anaerobic infections were diagnosed, were treated with metronidazole either orally (33) or rectally (15). Complete recovery occurred in 38 infections, while in 9 there was a satisfactory response, and 3 were considered as treatment failures. Thirteen of the 15 patients treated with suppositories had a complete recovery, while the other patients had a satisfactory response. Serum levels for metronidazole were obtained in 19 patients as well as in 12 volunteers. 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| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1977-07, Vol.3 (4), p.347-353 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | OUP_牛津大学出版社过刊（NSTL购买）; MEDLINE |
| subjects | Administration, Oral Adolescent Adult Aged Anaerobiosis Bacterial Infections - drug therapy Bacterial Infections - microbiology Female Humans Male Metronidazole - administration & dosage Metronidazole - blood Metronidazole - therapeutic use Middle Aged Rectum Suppositories |
| title | Treatment with metronidazole of 48 patients with serious anaerobic infections |
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