Blood flow and uptake of glucose and amino acids in ischemic muscle
In order to examine muscle ischemia, muscle blood flow in the rat hindlimb was decreased by vessel ligation. Amino acid uptake, studied with [ 14C]α-aminoisobutyric acid, was decreased in ischemic Type I (soleus) muscle. Glucose uptake, studied with [ 14C]deoxyglucose, was increased in Type I muscle...
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| Veröffentlicht in: | Journal of the neurological sciences 1977-08, Vol.33 (1), p.155-160 |
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| container_end_page | 160 |
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| container_issue | 1 |
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| container_title | Journal of the neurological sciences |
| container_volume | 33 |
| creator | Carroll, James E. Kaiser, Kenneth K. Bondy, Stephen C. Purdy, Janet L. |
| description | In order to examine muscle ischemia, muscle blood flow in the rat hindlimb was decreased by vessel ligation. Amino acid uptake, studied with [
14C]α-aminoisobutyric acid, was decreased in ischemic Type I (soleus) muscle. Glucose uptake, studied with [
14C]deoxyglucose, was increased in Type I muscle. These changes were temporally associated with histologic changes of ischemia in soleus muscle. Denervation, atrophy, and hypertrophy also produced uptake changes with these techniques, and although more prominent in soleus, the changes were also seen in Type II muscle. |
| doi_str_mv | 10.1016/0022-510X(77)90189-7 |
| format | Article |
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14C]α-aminoisobutyric acid, was decreased in ischemic Type I (soleus) muscle. Glucose uptake, studied with [
14C]deoxyglucose, was increased in Type I muscle. These changes were temporally associated with histologic changes of ischemia in soleus muscle. Denervation, atrophy, and hypertrophy also produced uptake changes with these techniques, and although more prominent in soleus, the changes were also seen in Type II muscle.</description><identifier>ISSN: 0022-510X</identifier><identifier>DOI: 10.1016/0022-510X(77)90189-7</identifier><identifier>PMID: 903779</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Absorption ; Aminoisobutyric Acids - metabolism ; Animals ; Antipyrine - metabolism ; Deoxy Sugars - metabolism ; Deoxyglucose - metabolism ; Hypertrophy ; Ischemia - metabolism ; Muscle Denervation ; Muscles - blood supply ; Muscles - metabolism ; Muscular Atrophy - metabolism ; Muscular Diseases - metabolism ; Rats ; Space life sciences</subject><ispartof>Journal of the neurological sciences, 1977-08, Vol.33 (1), p.155-160</ispartof><rights>1977</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-f850f7e1e70d6b6a8515866a79b90e90905ab63005061364cb0cb3da253a537a3</citedby><cites>FETCH-LOGICAL-c402t-f850f7e1e70d6b6a8515866a79b90e90905ab63005061364cb0cb3da253a537a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(77)90189-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/903779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carroll, James E.</creatorcontrib><creatorcontrib>Kaiser, Kenneth K.</creatorcontrib><creatorcontrib>Bondy, Stephen C.</creatorcontrib><creatorcontrib>Purdy, Janet L.</creatorcontrib><title>Blood flow and uptake of glucose and amino acids in ischemic muscle</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>In order to examine muscle ischemia, muscle blood flow in the rat hindlimb was decreased by vessel ligation. Amino acid uptake, studied with [
14C]α-aminoisobutyric acid, was decreased in ischemic Type I (soleus) muscle. Glucose uptake, studied with [
14C]deoxyglucose, was increased in Type I muscle. These changes were temporally associated with histologic changes of ischemia in soleus muscle. Denervation, atrophy, and hypertrophy also produced uptake changes with these techniques, and although more prominent in soleus, the changes were also seen in Type II muscle.</description><subject>Absorption</subject><subject>Aminoisobutyric Acids - metabolism</subject><subject>Animals</subject><subject>Antipyrine - metabolism</subject><subject>Deoxy Sugars - metabolism</subject><subject>Deoxyglucose - metabolism</subject><subject>Hypertrophy</subject><subject>Ischemia - metabolism</subject><subject>Muscle Denervation</subject><subject>Muscles - blood supply</subject><subject>Muscles - metabolism</subject><subject>Muscular Atrophy - metabolism</subject><subject>Muscular Diseases - metabolism</subject><subject>Rats</subject><subject>Space life sciences</subject><issn>0022-510X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPxDAQhF3wPvgHV7hCUATWSWzHDRKceEkn0YBEZzn2BgxJfMQJiH9P7qErqVaa2RntfoRMGVwwYOISIE0TzuD1TMpzBaxQidwhh1v5gBzF-AEAoijUPtlTkEmpDsnspg7B0aoOP9S0jg6L3nwiDRV9qwcbIq5U0_g2UGO9i9S31Ef7jo23tBmirfGY7FamjniymRPycnf7PHtI5k_3j7PreWJzSPukKjhUEhlKcKIUpuCMF0IYqUoFqEABN6XIADgIlonclmDLzJmUZ4Zn0mQTcrruXXTha8DY62a8BOvatBiGqIscpOCiGBfz9aLtQowdVnrR-cZ0v5qBXuLSSy56yUVLqVe4tBxj003_UDbotqE1q9G-Wts4_vjtsdPRemwtOt-h7bUL_v_-P0mWegs</recordid><startdate>197708</startdate><enddate>197708</enddate><creator>Carroll, James E.</creator><creator>Kaiser, Kenneth K.</creator><creator>Bondy, Stephen C.</creator><creator>Purdy, Janet L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197708</creationdate><title>Blood flow and uptake of glucose and amino acids in ischemic muscle</title><author>Carroll, James E. ; Kaiser, Kenneth K. ; Bondy, Stephen C. ; Purdy, Janet L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-f850f7e1e70d6b6a8515866a79b90e90905ab63005061364cb0cb3da253a537a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Absorption</topic><topic>Aminoisobutyric Acids - metabolism</topic><topic>Animals</topic><topic>Antipyrine - metabolism</topic><topic>Deoxy Sugars - metabolism</topic><topic>Deoxyglucose - metabolism</topic><topic>Hypertrophy</topic><topic>Ischemia - metabolism</topic><topic>Muscle Denervation</topic><topic>Muscles - blood supply</topic><topic>Muscles - metabolism</topic><topic>Muscular Atrophy - metabolism</topic><topic>Muscular Diseases - metabolism</topic><topic>Rats</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carroll, James E.</creatorcontrib><creatorcontrib>Kaiser, Kenneth K.</creatorcontrib><creatorcontrib>Bondy, Stephen C.</creatorcontrib><creatorcontrib>Purdy, Janet L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carroll, James E.</au><au>Kaiser, Kenneth K.</au><au>Bondy, Stephen C.</au><au>Purdy, Janet L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood flow and uptake of glucose and amino acids in ischemic muscle</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1977-08</date><risdate>1977</risdate><volume>33</volume><issue>1</issue><spage>155</spage><epage>160</epage><pages>155-160</pages><issn>0022-510X</issn><abstract>In order to examine muscle ischemia, muscle blood flow in the rat hindlimb was decreased by vessel ligation. Amino acid uptake, studied with [
14C]α-aminoisobutyric acid, was decreased in ischemic Type I (soleus) muscle. Glucose uptake, studied with [
14C]deoxyglucose, was increased in Type I muscle. These changes were temporally associated with histologic changes of ischemia in soleus muscle. Denervation, atrophy, and hypertrophy also produced uptake changes with these techniques, and although more prominent in soleus, the changes were also seen in Type II muscle.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>903779</pmid><doi>10.1016/0022-510X(77)90189-7</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the neurological sciences, 1977-08, Vol.33 (1), p.155-160 |
| issn | 0022-510X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Absorption Aminoisobutyric Acids - metabolism Animals Antipyrine - metabolism Deoxy Sugars - metabolism Deoxyglucose - metabolism Hypertrophy Ischemia - metabolism Muscle Denervation Muscles - blood supply Muscles - metabolism Muscular Atrophy - metabolism Muscular Diseases - metabolism Rats Space life sciences |
| title | Blood flow and uptake of glucose and amino acids in ischemic muscle |
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