A STUDY ON MIDECAMYCIN GRANULES IN ACUTE RESPIRATORY DISEASES IN INFANTS
We have undertaken some basic and clinical studies on midecamycin granules with following results: 1) After ingestion of 4g of midecamycin granules, peak blood levels (1.51μg/ml on an average) appeared at one hour in infants, detectable amount lasting for 6 hours. 2) Urinary excretion within 6 hours...
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| Veröffentlicht in: | Japanese journal of antibiotics 1977/08/25, Vol.30(8), pp.587-592 |
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| container_issue | 8 |
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| container_title | Japanese journal of antibiotics |
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| creator | SATO, HAJIME FUJII, SHODO HIRAMA, YUICHI NAKAZAWA, SUSUMU WATANABE, OSAMU KANDA, SHUJI |
| description | We have undertaken some basic and clinical studies on midecamycin granules with following results: 1) After ingestion of 4g of midecamycin granules, peak blood levels (1.51μg/ml on an average) appeared at one hour in infants, detectable amount lasting for 6 hours. 2) Urinary excretion within 6 hours ranged from 1.1 to 2.7% of the drug dosed. 3) In the treatment of a total of 19 acute cases, consisting of 9 cases of tonsillitis, 7 cases of lacunar tonsillitis and 3 cases of bronchitis, midecamycin was found effective in 79% of the cases. 4) In all the 3 cases of pneumonia due to Mycoplasma, response to midecamycin was assessed as excellent. 5) Hepatic and renal functions tests performed in cases treated with the drug for a prolonged period (40-50 mg/kg for 13-18 days) revealed no undesirable effect, indicating that midecamycin can be administered continuously to younger infants with infections. |
| doi_str_mv | 10.11553/antibiotics1968b.30.587 |
| format | Article |
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| ispartof | The Japanese Journal of Antibiotics, 1977/08/25, Vol.30(8), pp.587-592 |
| issn | 0368-2781 2186-5477 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Disease Anti-Bacterial Agents - administration & dosage Child, Preschool Dosage Forms Drug Evaluation Female Humans Leucomycins - administration & dosage Leucomycins - blood Leucomycins - urine Male Respiratory Tract Infections - drug therapy |
| title | A STUDY ON MIDECAMYCIN GRANULES IN ACUTE RESPIRATORY DISEASES IN INFANTS |
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