Mechanism of the Cholesterol-depressing Effect of Pectin in the Cholesterol-fed Rat
The mechanisms by which dietary pectin lowers plasma and liver cholesterol levels in cholesterol-fed rats were studied. Pectin feeding increased fecal bile acid excretion in cholesterol-fed rats. In vitro studies with inverted intestinal sacs demonstrated that pectin decreased taurocholic acid trans...
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| Veröffentlicht in: | The Journal of nutrition 1966-02, Vol.88 (2), p.209-214 |
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| container_title | The Journal of nutrition |
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| creator | Leveille, G.A. Sauberlich, H.E. |
| description | The mechanisms by which dietary pectin lowers plasma and liver cholesterol levels in cholesterol-fed rats were studied. Pectin feeding increased fecal bile acid excretion in cholesterol-fed rats. In vitro studies with inverted intestinal sacs demonstrated that pectin decreased taurocholic acid transport by approximately 50%. Rats responded to dietary pectin and cholestyramine, a known inhibitor of bile acid absorption, similarly. Cholesterol-4-14C absorption was somewhat depressed by dietary pectin as evidenced by fecal radioactive cholesterol excretion and deposition of cholesterol-4-14C in liver. The effect of pectin on plasma and liver cholesterol was not altered by dietary succinylsulfathiazole. These data are interpreted to suggest that the hypocholesterolemic effects of pectin are not mediated by an alteration of the intestinal microflora. The results of this study indicate that pectin lowers plasma and liver cholesterol levels in cholesterol-fed rats primarily by inhibiting bile acid absorption and also by reducing cholesterol absorption. |
| doi_str_mv | 10.1093/jn/88.2.209 |
| format | Article |
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Pectin feeding increased fecal bile acid excretion in cholesterol-fed rats. In vitro studies with inverted intestinal sacs demonstrated that pectin decreased taurocholic acid transport by approximately 50%. Rats responded to dietary pectin and cholestyramine, a known inhibitor of bile acid absorption, similarly. Cholesterol-4-14C absorption was somewhat depressed by dietary pectin as evidenced by fecal radioactive cholesterol excretion and deposition of cholesterol-4-14C in liver. The effect of pectin on plasma and liver cholesterol was not altered by dietary succinylsulfathiazole. These data are interpreted to suggest that the hypocholesterolemic effects of pectin are not mediated by an alteration of the intestinal microflora. The results of this study indicate that pectin lowers plasma and liver cholesterol levels in cholesterol-fed rats primarily by inhibiting bile acid absorption and also by reducing cholesterol absorption.</description><identifier>ISSN: 0022-3166</identifier><identifier>DOI: 10.1093/jn/88.2.209</identifier><identifier>PMID: 5905007</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Anticholesteremic Agents - pharmacology ; Bile Acids and Salts - metabolism ; Carbon Isotopes ; Cholesterol - metabolism ; Cholestyramine Resin - pharmacology ; Dietary Carbohydrates ; In Vitro Techniques ; Liver - metabolism ; Male ; Pectins - pharmacology ; Radiometry ; Rats ; Sulfathiazoles - pharmacology</subject><ispartof>The Journal of nutrition, 1966-02, Vol.88 (2), p.209-214</ispartof><rights>1966 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-14b478bee4a69eaeea18e08cee97666490fe281ca6f46adff32e943225b3d4573</citedby><cites>FETCH-LOGICAL-c367t-14b478bee4a69eaeea18e08cee97666490fe281ca6f46adff32e943225b3d4573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5905007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leveille, G.A.</creatorcontrib><creatorcontrib>Sauberlich, H.E.</creatorcontrib><title>Mechanism of the Cholesterol-depressing Effect of Pectin in the Cholesterol-fed Rat</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The mechanisms by which dietary pectin lowers plasma and liver cholesterol levels in cholesterol-fed rats were studied. Pectin feeding increased fecal bile acid excretion in cholesterol-fed rats. In vitro studies with inverted intestinal sacs demonstrated that pectin decreased taurocholic acid transport by approximately 50%. Rats responded to dietary pectin and cholestyramine, a known inhibitor of bile acid absorption, similarly. Cholesterol-4-14C absorption was somewhat depressed by dietary pectin as evidenced by fecal radioactive cholesterol excretion and deposition of cholesterol-4-14C in liver. The effect of pectin on plasma and liver cholesterol was not altered by dietary succinylsulfathiazole. These data are interpreted to suggest that the hypocholesterolemic effects of pectin are not mediated by an alteration of the intestinal microflora. The results of this study indicate that pectin lowers plasma and liver cholesterol levels in cholesterol-fed rats primarily by inhibiting bile acid absorption and also by reducing cholesterol absorption.</description><subject>Animals</subject><subject>Anticholesteremic Agents - pharmacology</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Carbon Isotopes</subject><subject>Cholesterol - metabolism</subject><subject>Cholestyramine Resin - pharmacology</subject><subject>Dietary Carbohydrates</subject><subject>In Vitro Techniques</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Pectins - pharmacology</subject><subject>Radiometry</subject><subject>Rats</subject><subject>Sulfathiazoles - pharmacology</subject><issn>0022-3166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLAzEURrNQaq2uXAuzciPT5jWZZCmlPqCi-FiHTObGpsyjJlPBf29KiwsRLnyLe_i49yB0QfCUYMVm624m5ZROKVZHaIwxpTkjQpyg0xjXGGPClRyhUaFwgXE5Rq-PYFem87HNepcNK8jmq76BOEDom7yGTYAYffeRLZwDO-yg55S-y9L8xR3U2YsZztCxM02E80NO0Pvt4m1-ny-f7h7mN8vcMlEOOeEVL2UFwI1QYAAMkYClBVClEIIr7IBKYo1wXJjaOUZBcUZpUbGaFyWboKt97yb0n9t0hG59tNA0poN-G7XkWJCSyQRe70Eb-hgDOL0JvjXhWxOsd9r0utNSaqqTtkRfHmq3VQv1L3twlvbFfg_pty8PQUfrobNQ-5DU6Lr3__b-AJfqfLI</recordid><startdate>196602</startdate><enddate>196602</enddate><creator>Leveille, G.A.</creator><creator>Sauberlich, H.E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196602</creationdate><title>Mechanism of the Cholesterol-depressing Effect of Pectin in the Cholesterol-fed Rat</title><author>Leveille, G.A. ; Sauberlich, H.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-14b478bee4a69eaeea18e08cee97666490fe281ca6f46adff32e943225b3d4573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Animals</topic><topic>Anticholesteremic Agents - pharmacology</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Carbon Isotopes</topic><topic>Cholesterol - metabolism</topic><topic>Cholestyramine Resin - pharmacology</topic><topic>Dietary Carbohydrates</topic><topic>In Vitro Techniques</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Pectins - pharmacology</topic><topic>Radiometry</topic><topic>Rats</topic><topic>Sulfathiazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leveille, G.A.</creatorcontrib><creatorcontrib>Sauberlich, H.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leveille, G.A.</au><au>Sauberlich, H.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanism of the Cholesterol-depressing Effect of Pectin in the Cholesterol-fed Rat</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1966-02</date><risdate>1966</risdate><volume>88</volume><issue>2</issue><spage>209</spage><epage>214</epage><pages>209-214</pages><issn>0022-3166</issn><abstract>The mechanisms by which dietary pectin lowers plasma and liver cholesterol levels in cholesterol-fed rats were studied. Pectin feeding increased fecal bile acid excretion in cholesterol-fed rats. In vitro studies with inverted intestinal sacs demonstrated that pectin decreased taurocholic acid transport by approximately 50%. Rats responded to dietary pectin and cholestyramine, a known inhibitor of bile acid absorption, similarly. Cholesterol-4-14C absorption was somewhat depressed by dietary pectin as evidenced by fecal radioactive cholesterol excretion and deposition of cholesterol-4-14C in liver. The effect of pectin on plasma and liver cholesterol was not altered by dietary succinylsulfathiazole. These data are interpreted to suggest that the hypocholesterolemic effects of pectin are not mediated by an alteration of the intestinal microflora. The results of this study indicate that pectin lowers plasma and liver cholesterol levels in cholesterol-fed rats primarily by inhibiting bile acid absorption and also by reducing cholesterol absorption.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5905007</pmid><doi>10.1093/jn/88.2.209</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 1966-02, Vol.88 (2), p.209-214 |
| issn | 0022-3166 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Anticholesteremic Agents - pharmacology Bile Acids and Salts - metabolism Carbon Isotopes Cholesterol - metabolism Cholestyramine Resin - pharmacology Dietary Carbohydrates In Vitro Techniques Liver - metabolism Male Pectins - pharmacology Radiometry Rats Sulfathiazoles - pharmacology |
| title | Mechanism of the Cholesterol-depressing Effect of Pectin in the Cholesterol-fed Rat |
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