A Comparison of Technetium Etidronate and Pyrophosphate for Acute Myocardial Infarct Imaging
Etidronate and pyrophosphate, labeled with Tc-95m and Tc-99m, were studied in experimentally infarcted mongrel dogs. A distribution study was conducted 2 hr after simultaneous administration of both agents in two groups of dogs. In one group, the injection was made 15 min after release of a 2-hr cor...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1977-09, Vol.18 (9), p.905-909 |
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| container_issue | 9 |
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| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 18 |
| creator | Williams, Craig C Nishiyama, Hiroshi Adolph, Robert J Romhilt, Donald W Sodd, Vincent J Saenger, Eugene L Gabel, Marjorie |
| description | Etidronate and pyrophosphate, labeled with Tc-95m and Tc-99m, were studied in experimentally infarcted mongrel dogs. A distribution study was conducted 2 hr after simultaneous administration of both agents in two groups of dogs. In one group, the injection was made 15 min after release of a 2-hr coronary arterial ligation. Another group was injected 48 hr after release of the ligation. The uptakes for each radiopharmaceutical and the ratio of uptakes for each sample were computed. The data show pyrophosphate to be a superior agent for the imaging of acute myocardial infarcts because of the higher uptake by infarcted myocardium and the greater contrast between infarcted myocardium and neighboring organs. |
| format | Article |
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A distribution study was conducted 2 hr after simultaneous administration of both agents in two groups of dogs. In one group, the injection was made 15 min after release of a 2-hr coronary arterial ligation. Another group was injected 48 hr after release of the ligation. The uptakes for each radiopharmaceutical and the ratio of uptakes for each sample were computed. The data show pyrophosphate to be a superior agent for the imaging of acute myocardial infarcts because of the higher uptake by infarcted myocardium and the greater contrast between infarcted myocardium and neighboring organs.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 197134</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Acute Disease ; Animals ; Diphosphates ; Dogs ; Etidronic Acid ; Myocardial Infarction - diagnosis ; Radionuclide Imaging ; Technetium</subject><ispartof>The Journal of nuclear medicine (1978), 1977-09, Vol.18 (9), p.905-909</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/197134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Craig C</creatorcontrib><creatorcontrib>Nishiyama, Hiroshi</creatorcontrib><creatorcontrib>Adolph, Robert J</creatorcontrib><creatorcontrib>Romhilt, Donald W</creatorcontrib><creatorcontrib>Sodd, Vincent J</creatorcontrib><creatorcontrib>Saenger, Eugene L</creatorcontrib><creatorcontrib>Gabel, Marjorie</creatorcontrib><title>A Comparison of Technetium Etidronate and Pyrophosphate for Acute Myocardial Infarct Imaging</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Etidronate and pyrophosphate, labeled with Tc-95m and Tc-99m, were studied in experimentally infarcted mongrel dogs. 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The data show pyrophosphate to be a superior agent for the imaging of acute myocardial infarcts because of the higher uptake by infarcted myocardium and the greater contrast between infarcted myocardium and neighboring organs.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Diphosphates</subject><subject>Dogs</subject><subject>Etidronic Acid</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Radionuclide Imaging</subject><subject>Technetium</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AYRQfxVav_wMWs3AUmmUcmy1KqFiq6qDshfPNIMyWZiTMJ0n-vpQVX93I5nMW9QLOcU55xIcpLNCO5yDPOCb9FdyntCSFCSnmDrvOqzCmboa8FXoZ-gOhS8Dg0eGt16-3oph6vRmdi8DBaDN7gj0MMQxvS0B6XJkS80NNfezsEDdE46PDaNxD1iNc97Jzf3aOrBrpkH845R5_Pq-3yNdu8v6yXi03WFlSMmaIFaGGIYrktqTIGJCVQSTCcaVs1iltFhaKMUyUarjVTpSpYZXmhqVQVnaOnk3eI4Xuyaax7l7TtOvA2TKmWjHDGyRF8PIOT6q2ph-h6iIf69Ma_p3W79sdFW_tJdxbikd37Ppd1VVeE018R3msV</recordid><startdate>197709</startdate><enddate>197709</enddate><creator>Williams, Craig C</creator><creator>Nishiyama, Hiroshi</creator><creator>Adolph, Robert J</creator><creator>Romhilt, Donald W</creator><creator>Sodd, Vincent J</creator><creator>Saenger, Eugene L</creator><creator>Gabel, Marjorie</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197709</creationdate><title>A Comparison of Technetium Etidronate and Pyrophosphate for Acute Myocardial Infarct Imaging</title><author>Williams, Craig C ; Nishiyama, Hiroshi ; Adolph, Robert J ; Romhilt, Donald W ; Sodd, Vincent J ; Saenger, Eugene L ; Gabel, Marjorie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h236t-b32ac6d0b41e73bdda830a98ad54ce9fb5eb36b3453b6f5cc4b7b249e52c38b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Diphosphates</topic><topic>Dogs</topic><topic>Etidronic Acid</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Radionuclide Imaging</topic><topic>Technetium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Craig C</creatorcontrib><creatorcontrib>Nishiyama, Hiroshi</creatorcontrib><creatorcontrib>Adolph, Robert J</creatorcontrib><creatorcontrib>Romhilt, Donald W</creatorcontrib><creatorcontrib>Sodd, Vincent J</creatorcontrib><creatorcontrib>Saenger, Eugene L</creatorcontrib><creatorcontrib>Gabel, Marjorie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Craig C</au><au>Nishiyama, Hiroshi</au><au>Adolph, Robert J</au><au>Romhilt, Donald W</au><au>Sodd, Vincent J</au><au>Saenger, Eugene L</au><au>Gabel, Marjorie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of Technetium Etidronate and Pyrophosphate for Acute Myocardial Infarct Imaging</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1977-09</date><risdate>1977</risdate><volume>18</volume><issue>9</issue><spage>905</spage><epage>909</epage><pages>905-909</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Etidronate and pyrophosphate, labeled with Tc-95m and Tc-99m, were studied in experimentally infarcted mongrel dogs. 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| ispartof | The Journal of nuclear medicine (1978), 1977-09, Vol.18 (9), p.905-909 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acute Disease Animals Diphosphates Dogs Etidronic Acid Myocardial Infarction - diagnosis Radionuclide Imaging Technetium |
| title | A Comparison of Technetium Etidronate and Pyrophosphate for Acute Myocardial Infarct Imaging |
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