Direct Synthesis of 1-Indanones via Pd-Catalyzed Olefination and Ethylene Glycol-Promoted Aldol-Type Annulation Cascade

A wide range of multisubstituted 1-indanones of potential pharmaceutical use were synthesized in a one-pot fashion in moderate to excellent yields via palladium catalysis in ethylene glycol. The Heck reaction first installs an enol functionality on the aromatic ring; this is followed by an ethylene...

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Veröffentlicht in:	Organic letters 2011-01, Vol.13 (2), p.268-271
Hauptverfasser:	Ruan, Jiwu, Iggo, Jonathan A, Xiao, Jianliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Alkenes - chemistry Catalysis Combinatorial Chemistry Techniques Cyclization Ethylene Glycol - chemistry Indans - chemical synthesis Indans - chemistry Molecular Structure Palladium - chemistry
Online-Zugang:	Volltext
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