Insulin and metformin may prevent renal injury in young type 2 diabetic Goto–Kakizaki rats

Type 2 diabetes is increasing at epidemic proportions throughout the world, and diabetic nephropathy is the principal cause of end stage renal failure. Approximately 40% of patients with type 2 diabetes may progress to nephropathy and a good metabolic control can prevent the development of diabetic...

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Veröffentlicht in:	European journal of pharmacology 2011-02, Vol.653 (1-3), p.89-94
Hauptverfasser:	Louro, Teresa M., Matafome, Paulo N., Nunes, Elsa C., Xavier da Cunha, Fernanda, Seiça, Raquel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AGE's Animals Biological and medical sciences Blood Glucose Body Weight C-reactive protein Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Diabetic Nephropathies - prevention & control diabetic nephropathy diet Diet, Atherogenic Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance fasting fibrosis Gliclazide - pharmacology glycemic effect high density lipoprotein cholesterol Hypoglycemic Agents - pharmacology Inflammation insulin Insulin - pharmacology Insulin Resistance kidneys Male Medical sciences metformin Metformin - pharmacology Nephropathy noninsulin-dependent diabetes mellitus Oxidative stress Oxidative Stress - drug effects patients Pharmacology. Drug treatments Rats renal failure triacylglycerols Type 2 diabetes
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