Cell death and hepatocarcinogenesis: Dysregulation of apoptosis signaling pathways

Hepatocellular carcinoma (HCC) remains a disease with a poor prognosis despite recent advances in the pathophysiology and treatment. Although the disease is biologically heterogeneous, dysregulation of cellular proliferation and apoptosis both occur frequently and contribute to the malignant phenoty...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2011-01, Vol.26 (s1), p.213-219
Hauptverfasser:	Schattenberg, Jorn Markus, Schuchmann, Marcus, Galle, Peter Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis Regulatory Proteins - metabolism Bcl-3 Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Cell Proliferation Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology cFLIP hepatocellular carcinoma Humans Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - therapy Mitochondria - metabolism NF-kappa B - metabolism NF-κB Receptors, Death Domain - metabolism Signal Transduction
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