A COMPARATIVE STUDY OF DIHYDROXYLATED PHENOTHIAZINE DERIVATIVES AS MITOCHONDRIAL INHIBITORS

— —The effects of several dihydroxylated phenothiazine derivatives on brain mitochondrial calcium retention, respiration and ATP synthesis were studied and compared to those of 7,8‐dihydroxy‐chlorpromazine. This compound has previously been shown to disrupt retention of calcium accumulated in the pr...

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Veröffentlicht in:	Journal of neurochemistry 1977-08, Vol.29 (2), p.245-249
Hauptverfasser:	Tjioe, Sarah A., Manian, A. A., O'neill, J. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - biosynthesis Animals Brain - drug effects Brain - metabolism Calcium - metabolism Mitochondria - drug effects Mitochondria - metabolism Oxygen Consumption - drug effects Phenothiazines - pharmacology Rats Structure-Activity Relationship
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