Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia

Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia

The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Sc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1965-02, Vol.147 (3660), p.869-870
Hauptverfasser: Eylar, Edwin H., Matioli, Gastone T.
Format: Artikel
Sprache:eng
Schlagworte:
Biosynthesis
Blood
Blood cells
Carbohydrate Metabolism
Cell Membrane
Cell membranes
Erythrocytes
Erythroid cells
Glycoproteins
Hemoglobins
Humans
Old Medline
Protein Biosynthesis
Proteins - metabolism
Reticulocytes
Thalassemia
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 870
container_issue 3660
container_start_page 869
container_title Science (American Association for the Advancement of Science)
container_volume 147
creator Eylar, Edwin H.
Matioli, Gastone T.
description The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Schiff reagent with the clinical picture of oligocythemia and microcytosis.
doi_str_mv 10.1126/science.147.3660.869
format Article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_83999659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1715489</jstor_id><sourcerecordid>1715489</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-9a806233c23bd0c0da382b0bc7bdd402199438159dec80352726c13817ebb2883</originalsourceid><addsrcrecordid>eNpFkE1Lw0AQhhdRbK3-gyI5eUvcj2Q_vGnRtlAQpJ6XzWZLtyTZmkkO-fduaaGnYeZ932HmQWhOcEYI5a9gvWuty0guMsY5ziRXN2hKsCpSRTG7RVOMGU8lFsUEPQAcMI6aYvdoQnKaF4KLKVov69GGYxd659vkwwcY237vwEMS-9XQmDb5cb23Qx3s2Dt4S96TTdRDezJs96Y2AK7x5hHd7UwN7ulSZ-j363O7WKWb7-V68b5JLSt4nyojMaeMWcrKCltcGSZpiUsryqrKMSVK5UySQlXOSswKKii3JE6EK0sqJZuhl_PeePTf4KDXjQfr6tq0LgygJVNK8fjnDOVno-0CQOd2-tj5xnSjJlifEOoLQh0R6hNCHRHG2PNl_1A2rrqGLsyiYX42HKAP3VUXpMilYv-233ec</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83999659</pqid></control><display><type>article</type><title>Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Eylar, Edwin H. ; Matioli, Gastone T.</creator><creatorcontrib>Eylar, Edwin H. ; Matioli, Gastone T.</creatorcontrib><description>The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Schiff reagent with the clinical picture of oligocythemia and microcytosis.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.147.3660.869</identifier><identifier>PMID: 14245767</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Biosynthesis ; Blood ; Blood cells ; Carbohydrate Metabolism ; Cell Membrane ; Cell membranes ; Erythrocytes ; Erythroid cells ; Glycoproteins ; Hemoglobins ; Humans ; Old Medline ; Protein Biosynthesis ; Proteins - metabolism ; Reticulocytes ; Thalassemia</subject><ispartof>Science (American Association for the Advancement of Science), 1965-02, Vol.147 (3660), p.869-870</ispartof><rights>Copyright 1965 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-9a806233c23bd0c0da382b0bc7bdd402199438159dec80352726c13817ebb2883</citedby><cites>FETCH-LOGICAL-c356t-9a806233c23bd0c0da382b0bc7bdd402199438159dec80352726c13817ebb2883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1715489$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1715489$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2883,2884,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14245767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eylar, Edwin H.</creatorcontrib><creatorcontrib>Matioli, Gastone T.</creatorcontrib><title>Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Schiff reagent with the clinical picture of oligocythemia and microcytosis.</description><subject>Biosynthesis</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Carbohydrate Metabolism</subject><subject>Cell Membrane</subject><subject>Cell membranes</subject><subject>Erythrocytes</subject><subject>Erythroid cells</subject><subject>Glycoproteins</subject><subject>Hemoglobins</subject><subject>Humans</subject><subject>Old Medline</subject><subject>Protein Biosynthesis</subject><subject>Proteins - metabolism</subject><subject>Reticulocytes</subject><subject>Thalassemia</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRbK3-gyI5eUvcj2Q_vGnRtlAQpJ6XzWZLtyTZmkkO-fduaaGnYeZ932HmQWhOcEYI5a9gvWuty0guMsY5ziRXN2hKsCpSRTG7RVOMGU8lFsUEPQAcMI6aYvdoQnKaF4KLKVov69GGYxd659vkwwcY237vwEMS-9XQmDb5cb23Qx3s2Dt4S96TTdRDezJs96Y2AK7x5hHd7UwN7ulSZ-j363O7WKWb7-V68b5JLSt4nyojMaeMWcrKCltcGSZpiUsryqrKMSVK5UySQlXOSswKKii3JE6EK0sqJZuhl_PeePTf4KDXjQfr6tq0LgygJVNK8fjnDOVno-0CQOd2-tj5xnSjJlifEOoLQh0R6hNCHRHG2PNl_1A2rrqGLsyiYX42HKAP3VUXpMilYv-233ec</recordid><startdate>19650219</startdate><enddate>19650219</enddate><creator>Eylar, Edwin H.</creator><creator>Matioli, Gastone T.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19650219</creationdate><title>Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia</title><author>Eylar, Edwin H. ; Matioli, Gastone T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-9a806233c23bd0c0da382b0bc7bdd402199438159dec80352726c13817ebb2883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Biosynthesis</topic><topic>Blood</topic><topic>Blood cells</topic><topic>Carbohydrate Metabolism</topic><topic>Cell Membrane</topic><topic>Cell membranes</topic><topic>Erythrocytes</topic><topic>Erythroid cells</topic><topic>Glycoproteins</topic><topic>Hemoglobins</topic><topic>Humans</topic><topic>Old Medline</topic><topic>Protein Biosynthesis</topic><topic>Proteins - metabolism</topic><topic>Reticulocytes</topic><topic>Thalassemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eylar, Edwin H.</creatorcontrib><creatorcontrib>Matioli, Gastone T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eylar, Edwin H.</au><au>Matioli, Gastone T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1965-02-19</date><risdate>1965</risdate><volume>147</volume><issue>3660</issue><spage>869</spage><epage>870</epage><pages>869-870</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Schiff reagent with the clinical picture of oligocythemia and microcytosis.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>14245767</pmid><doi>10.1126/science.147.3660.869</doi><tpages>2</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1965-02, Vol.147 (3660), p.869-870
issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_83999659
source MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science
subjects Biosynthesis
Blood
Blood cells
Carbohydrate Metabolism
Cell Membrane
Cell membranes
Erythrocytes
Erythroid cells
Glycoproteins
Hemoglobins
Humans
Old Medline
Protein Biosynthesis
Proteins - metabolism
Reticulocytes
Thalassemia
title Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T18%3A35%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glycoprotein%20Biosynthesis%20in%20Human%20Reticulocytes:%20A%20Lesion%20in%20Thalassemia&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Eylar,%20Edwin%20H.&rft.date=1965-02-19&rft.volume=147&rft.issue=3660&rft.spage=869&rft.epage=870&rft.pages=869-870&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.147.3660.869&rft_dat=%3Cjstor_proqu%3E1715489%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83999659&rft_id=info:pmid/14245767&rft_jstor_id=1715489&rfr_iscdi=true