Nonelectrolyte Transport in Muscle during Induced Protein Loss
The accelerated loss of protein from Rana pipiens sartorius muscle following the induction of rigor by 100 millimolar 1-pentanol is not accompanied by increase in the rate constant for the efflux of urea. This observation is not readily accounted for by classical lipid-pore membrane permeability mod...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1965-04, Vol.148 (3666), p.80-83 |
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| creator | Fenichel, I. Robert Horowitz, Samuel B. |
| description | The accelerated loss of protein from Rana pipiens sartorius muscle following the induction of rigor by 100 millimolar 1-pentanol is not accompanied by increase in the rate constant for the efflux of urea. This observation is not readily accounted for by classical lipid-pore membrane permeability models. Alternative models are considered, in which protein and nonelectrolyte transport are dissociated; the dissociation could be (i) topological, due to compartmentalization, or (ii) functional, for example, if protein loss were due to change of the state of intracellular protein or if urea transport were limited by diffusion in the cytoplasm. |
| doi_str_mv | 10.1126/science.148.3666.80 |
| format | Article |
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Alternative models are considered, in which protein and nonelectrolyte transport are dissociated; the dissociation could be (i) topological, due to compartmentalization, or (ii) functional, for example, if protein loss were due to change of the state of intracellular protein or if urea transport were limited by diffusion in the cytoplasm.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.148.3666.80</identifier><identifier>PMID: 14258727</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Alcohols ; Animals ; Anura ; Biological Transport ; Carbon Isotopes ; Cell Membrane Permeability ; Infants ; Molecules ; Muscles ; Narcosis ; Nonelectrolytes ; Old Medline ; P branes ; Permeability ; Pharmacology ; Proteins ; Radiometry ; Ranidae ; Sex chromatin ; Solutes ; String theory ; Urea</subject><ispartof>Science (American Association for the Advancement of Science), 1965-04, Vol.148 (3666), p.80-83</ispartof><rights>Copyright 1965 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-3223dab112a04fec55f8b30079c6e7c6d73896bd03f03e95239646f4fbcaed483</citedby><cites>FETCH-LOGICAL-c386t-3223dab112a04fec55f8b30079c6e7c6d73896bd03f03e95239646f4fbcaed483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1715345$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1715345$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,2871,2872,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14258727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fenichel, I. Robert</creatorcontrib><creatorcontrib>Horowitz, Samuel B.</creatorcontrib><title>Nonelectrolyte Transport in Muscle during Induced Protein Loss</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The accelerated loss of protein from Rana pipiens sartorius muscle following the induction of rigor by 100 millimolar 1-pentanol is not accompanied by increase in the rate constant for the efflux of urea. This observation is not readily accounted for by classical lipid-pore membrane permeability models. Alternative models are considered, in which protein and nonelectrolyte transport are dissociated; the dissociation could be (i) topological, due to compartmentalization, or (ii) functional, for example, if protein loss were due to change of the state of intracellular protein or if urea transport were limited by diffusion in the cytoplasm.</description><subject>Alcohols</subject><subject>Animals</subject><subject>Anura</subject><subject>Biological Transport</subject><subject>Carbon Isotopes</subject><subject>Cell Membrane Permeability</subject><subject>Infants</subject><subject>Molecules</subject><subject>Muscles</subject><subject>Narcosis</subject><subject>Nonelectrolytes</subject><subject>Old Medline</subject><subject>P branes</subject><subject>Permeability</subject><subject>Pharmacology</subject><subject>Proteins</subject><subject>Radiometry</subject><subject>Ranidae</subject><subject>Sex chromatin</subject><subject>Solutes</subject><subject>String theory</subject><subject>Urea</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EoqXwBSCUFbuEcSZ27A0SqnhUKo9FWVuJPUGp0qTYyaJ_T6pW6moW99yr0WHslkPCeSofg62ptZTwTCUopUwUnLEpBy1inQKesykAylhBLibsKoQ1wJhpvGQTnqVC5Wk-ZU-fXUsN2d53za6naOWLNmw730d1G30MwTYUucHX7W-0aN1gyUXfvutpTJddCNfsoiqaQDfHO2M_ry-r-Xu8_HpbzJ-XsUUl-xjTFF1Rjm8XkFVkhahUiQC5tpJyK12OSsvSAVaApEWKWmayyqrSFuQyhTP2cNjd-u5voNCbTR0sNU3RUjcEo1BrCRJGEA-g9eN7niqz9fWm8DvDwey1maM2M2oze21G7Vv3x_mh3JA7dY6eRuDuAKxD3_lTnnOBmcB_q1pz_g</recordid><startdate>19650402</startdate><enddate>19650402</enddate><creator>Fenichel, I. 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Robert</au><au>Horowitz, Samuel B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonelectrolyte Transport in Muscle during Induced Protein Loss</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1965-04-02</date><risdate>1965</risdate><volume>148</volume><issue>3666</issue><spage>80</spage><epage>83</epage><pages>80-83</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>The accelerated loss of protein from Rana pipiens sartorius muscle following the induction of rigor by 100 millimolar 1-pentanol is not accompanied by increase in the rate constant for the efflux of urea. This observation is not readily accounted for by classical lipid-pore membrane permeability models. Alternative models are considered, in which protein and nonelectrolyte transport are dissociated; the dissociation could be (i) topological, due to compartmentalization, or (ii) functional, for example, if protein loss were due to change of the state of intracellular protein or if urea transport were limited by diffusion in the cytoplasm.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>14258727</pmid><doi>10.1126/science.148.3666.80</doi><tpages>4</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 1965-04, Vol.148 (3666), p.80-83 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83996060 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Alcohols Animals Anura Biological Transport Carbon Isotopes Cell Membrane Permeability Infants Molecules Muscles Narcosis Nonelectrolytes Old Medline P branes Permeability Pharmacology Proteins Radiometry Ranidae Sex chromatin Solutes String theory Urea |
| title | Nonelectrolyte Transport in Muscle during Induced Protein Loss |
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