Intracellular enzymes and their localization in slender and stumpy forms of Trypanosoma brucei rhodesiense
Acid phosphatase and cathepsin D activity is greater in stumpy than in slender forms, especially when estimations are made on a ‘light lysosomal’ fraction. Acid phosphatase is localized in the region of the flagellar pocket in slender forms but is present in lysosomes, phagolysosomes, autophagosomes...
Gespeichert in:
| Veröffentlicht in: | International journal for parasitology 1977-04, Vol.7 (2), p.139-147 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 147 |
|---|---|
| container_issue | 2 |
| container_start_page | 139 |
| container_title | International journal for parasitology |
| container_volume | 7 |
| creator | Venkatesan, S. Bird, R.G. Ormerod, W.E. |
| description | Acid phosphatase and cathepsin D activity is greater in stumpy than in slender forms, especially when estimations are made on a ‘light lysosomal’ fraction. Acid phosphatase is localized in the region of the flagellar pocket in slender forms but is present in lysosomes, phagolysosomes, autophagosomes and rough endoplasmic reticulum of stumpy forms. In stumpy forms dense bodies develop the macrocrystalline structure of peroxisomes. Intense enzyme activity in stumpy forms appears to be associated with absorption of lipid from the plasma by a mechanism similar to but of greater intensity than that described in atheromatous rabbit aorta. |
| doi_str_mv | 10.1016/0020-7519(77)90082-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_83995387</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0020751977900820</els_id><sourcerecordid>83995387</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-f68b1c52136629fbf977b01df4dae2ce5d5a2757ccd7eca4155b4b845b34ce73</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS3Eqzz-QQdPCIaAHdtxsiChipeExNLdcuwb1VViFztBCr-epkUdme5wv3Ok8yE0p-SeElo8EJKTTApa3Up5VxFS5hk5QjNayiojlIljNDsg5-gipTUhVDDOz9BpKVlR8hlav_s-agNtO7Q6YvA_YwcJa29xvwIXcRuMbt2P7l3w2HmcWvAW4o5I_dBtRtyE2CUcGryM40b7kEKncR0HAw7HVbCQHPgEV-ik0W2C6797iZYvz8vFW_bx-fq-ePrIDBNFnzVFWVMjcsqKIq-auqmkrAm1DbcacgPCCp1LIY2xEozmVIia1yUXNeMGJLtEN_vaTQxfA6RedS5NA7WHMCRVsqoSrJxAvgdNDClFaNQmuk7HUVGiJsFqsqcme0pKtROsyDY2_-sf6g7sIbQ3un0_7t-wnfjtIKpktvMNWBfB9MoG93__L_s6jNY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83995387</pqid></control><display><type>article</type><title>Intracellular enzymes and their localization in slender and stumpy forms of Trypanosoma brucei rhodesiense</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Venkatesan, S. ; Bird, R.G. ; Ormerod, W.E.</creator><creatorcontrib>Venkatesan, S. ; Bird, R.G. ; Ormerod, W.E.</creatorcontrib><description>Acid phosphatase and cathepsin D activity is greater in stumpy than in slender forms, especially when estimations are made on a ‘light lysosomal’ fraction. Acid phosphatase is localized in the region of the flagellar pocket in slender forms but is present in lysosomes, phagolysosomes, autophagosomes and rough endoplasmic reticulum of stumpy forms. In stumpy forms dense bodies develop the macrocrystalline structure of peroxisomes. Intense enzyme activity in stumpy forms appears to be associated with absorption of lipid from the plasma by a mechanism similar to but of greater intensity than that described in atheromatous rabbit aorta.</description><identifier>ISSN: 0020-7519</identifier><identifier>EISSN: 1879-0135</identifier><identifier>DOI: 10.1016/0020-7519(77)90082-0</identifier><identifier>PMID: 873684</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>acid phosphatase ; Acid Phosphatase - metabolism ; Animals ; autophagosome ; cathepsin ; Cathepsins - metabolism ; cholesterol ester ; Cytoplasmic Granules - enzymology ; glucuronidase ; lipids ; lysosomes ; peroxisome ; phagolysosome ; Trypanosoma brucei ; Trypanosoma brucei brucei - enzymology ; Trypanosoma brucei brucei - growth & development ; Trypanosoma brucei brucei - ultrastructure</subject><ispartof>International journal for parasitology, 1977-04, Vol.7 (2), p.139-147</ispartof><rights>1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-f68b1c52136629fbf977b01df4dae2ce5d5a2757ccd7eca4155b4b845b34ce73</citedby><cites>FETCH-LOGICAL-c356t-f68b1c52136629fbf977b01df4dae2ce5d5a2757ccd7eca4155b4b845b34ce73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0020-7519(77)90082-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/873684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venkatesan, S.</creatorcontrib><creatorcontrib>Bird, R.G.</creatorcontrib><creatorcontrib>Ormerod, W.E.</creatorcontrib><title>Intracellular enzymes and their localization in slender and stumpy forms of Trypanosoma brucei rhodesiense</title><title>International journal for parasitology</title><addtitle>Int J Parasitol</addtitle><description>Acid phosphatase and cathepsin D activity is greater in stumpy than in slender forms, especially when estimations are made on a ‘light lysosomal’ fraction. Acid phosphatase is localized in the region of the flagellar pocket in slender forms but is present in lysosomes, phagolysosomes, autophagosomes and rough endoplasmic reticulum of stumpy forms. In stumpy forms dense bodies develop the macrocrystalline structure of peroxisomes. Intense enzyme activity in stumpy forms appears to be associated with absorption of lipid from the plasma by a mechanism similar to but of greater intensity than that described in atheromatous rabbit aorta.</description><subject>acid phosphatase</subject><subject>Acid Phosphatase - metabolism</subject><subject>Animals</subject><subject>autophagosome</subject><subject>cathepsin</subject><subject>Cathepsins - metabolism</subject><subject>cholesterol ester</subject><subject>Cytoplasmic Granules - enzymology</subject><subject>glucuronidase</subject><subject>lipids</subject><subject>lysosomes</subject><subject>peroxisome</subject><subject>phagolysosome</subject><subject>Trypanosoma brucei</subject><subject>Trypanosoma brucei brucei - enzymology</subject><subject>Trypanosoma brucei brucei - growth & development</subject><subject>Trypanosoma brucei brucei - ultrastructure</subject><issn>0020-7519</issn><issn>1879-0135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS3Eqzz-QQdPCIaAHdtxsiChipeExNLdcuwb1VViFztBCr-epkUdme5wv3Ok8yE0p-SeElo8EJKTTApa3Up5VxFS5hk5QjNayiojlIljNDsg5-gipTUhVDDOz9BpKVlR8hlav_s-agNtO7Q6YvA_YwcJa29xvwIXcRuMbt2P7l3w2HmcWvAW4o5I_dBtRtyE2CUcGryM40b7kEKncR0HAw7HVbCQHPgEV-ik0W2C6797iZYvz8vFW_bx-fq-ePrIDBNFnzVFWVMjcsqKIq-auqmkrAm1DbcacgPCCp1LIY2xEozmVIia1yUXNeMGJLtEN_vaTQxfA6RedS5NA7WHMCRVsqoSrJxAvgdNDClFaNQmuk7HUVGiJsFqsqcme0pKtROsyDY2_-sf6g7sIbQ3un0_7t-wnfjtIKpktvMNWBfB9MoG93__L_s6jNY</recordid><startdate>197704</startdate><enddate>197704</enddate><creator>Venkatesan, S.</creator><creator>Bird, R.G.</creator><creator>Ormerod, W.E.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197704</creationdate><title>Intracellular enzymes and their localization in slender and stumpy forms of Trypanosoma brucei rhodesiense</title><author>Venkatesan, S. ; Bird, R.G. ; Ormerod, W.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-f68b1c52136629fbf977b01df4dae2ce5d5a2757ccd7eca4155b4b845b34ce73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>acid phosphatase</topic><topic>Acid Phosphatase - metabolism</topic><topic>Animals</topic><topic>autophagosome</topic><topic>cathepsin</topic><topic>Cathepsins - metabolism</topic><topic>cholesterol ester</topic><topic>Cytoplasmic Granules - enzymology</topic><topic>glucuronidase</topic><topic>lipids</topic><topic>lysosomes</topic><topic>peroxisome</topic><topic>phagolysosome</topic><topic>Trypanosoma brucei</topic><topic>Trypanosoma brucei brucei - enzymology</topic><topic>Trypanosoma brucei brucei - growth & development</topic><topic>Trypanosoma brucei brucei - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Venkatesan, S.</creatorcontrib><creatorcontrib>Bird, R.G.</creatorcontrib><creatorcontrib>Ormerod, W.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Venkatesan, S.</au><au>Bird, R.G.</au><au>Ormerod, W.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracellular enzymes and their localization in slender and stumpy forms of Trypanosoma brucei rhodesiense</atitle><jtitle>International journal for parasitology</jtitle><addtitle>Int J Parasitol</addtitle><date>1977-04</date><risdate>1977</risdate><volume>7</volume><issue>2</issue><spage>139</spage><epage>147</epage><pages>139-147</pages><issn>0020-7519</issn><eissn>1879-0135</eissn><abstract>Acid phosphatase and cathepsin D activity is greater in stumpy than in slender forms, especially when estimations are made on a ‘light lysosomal’ fraction. Acid phosphatase is localized in the region of the flagellar pocket in slender forms but is present in lysosomes, phagolysosomes, autophagosomes and rough endoplasmic reticulum of stumpy forms. In stumpy forms dense bodies develop the macrocrystalline structure of peroxisomes. Intense enzyme activity in stumpy forms appears to be associated with absorption of lipid from the plasma by a mechanism similar to but of greater intensity than that described in atheromatous rabbit aorta.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>873684</pmid><doi>10.1016/0020-7519(77)90082-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7519 |
| ispartof | International journal for parasitology, 1977-04, Vol.7 (2), p.139-147 |
| issn | 0020-7519 1879-0135 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83995387 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | acid phosphatase Acid Phosphatase - metabolism Animals autophagosome cathepsin Cathepsins - metabolism cholesterol ester Cytoplasmic Granules - enzymology glucuronidase lipids lysosomes peroxisome phagolysosome Trypanosoma brucei Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - growth & development Trypanosoma brucei brucei - ultrastructure |
| title | Intracellular enzymes and their localization in slender and stumpy forms of Trypanosoma brucei rhodesiense |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T21%3A03%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intracellular%20enzymes%20and%20their%20localization%20in%20slender%20and%20stumpy%20forms%20of%20Trypanosoma%20brucei%20rhodesiense&rft.jtitle=International%20journal%20for%20parasitology&rft.au=Venkatesan,%20S.&rft.date=1977-04&rft.volume=7&rft.issue=2&rft.spage=139&rft.epage=147&rft.pages=139-147&rft.issn=0020-7519&rft.eissn=1879-0135&rft_id=info:doi/10.1016/0020-7519(77)90082-0&rft_dat=%3Cproquest_cross%3E83995387%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83995387&rft_id=info:pmid/873684&rft_els_id=0020751977900820&rfr_iscdi=true |