Determination of Antialdosterone Activity in Normal Dogs
Summary A method is described for detecting an aldosterone antagonist over a 6-hour period in the unanesthetized intact dog. The method is based upon the ability of an aldosterone antagonist to overcome the depressed urinary Na/K ratio caused by administration of the potent mineralocorticoid 9 α-flu...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-03, Vol.118 (3), p.806-809 |
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| container_end_page | 809 |
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| container_issue | 3 |
| container_start_page | 806 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 118 |
| creator | Rosenthale, Marvin E. Schneider, Fred Kassarich, Jacob Datko, Louis |
| description | Summary
A method is described for detecting an aldosterone antagonist over a 6-hour period in the unanesthetized intact dog. The method is based upon the ability of an aldosterone antagonist to overcome the depressed urinary Na/K ratio caused by administration of the potent mineralocorticoid 9 α-fluorohydrocortisone. Using this procedure, it was shown that spironolactone-A is active at an oral dose as low as 3 mg/kg, and at 12 mg/kg has a significant natriuretic effect. |
| doi_str_mv | 10.3181/00379727-118-29977 |
| format | Article |
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A method is described for detecting an aldosterone antagonist over a 6-hour period in the unanesthetized intact dog. The method is based upon the ability of an aldosterone antagonist to overcome the depressed urinary Na/K ratio caused by administration of the potent mineralocorticoid 9 α-fluorohydrocortisone. Using this procedure, it was shown that spironolactone-A is active at an oral dose as low as 3 mg/kg, and at 12 mg/kg has a significant natriuretic effect.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-118-29977</identifier><identifier>PMID: 14264565</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Body Fluids ; Chlorides ; Dogs ; Fludrocortisone ; Mineralocorticoid Receptor Antagonists ; Natriuresis ; Old Medline ; Pharmacology ; Potassium ; Spironolactone ; Urine</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1965-03, Vol.118 (3), p.806-809</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14264565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenthale, Marvin E.</creatorcontrib><creatorcontrib>Schneider, Fred</creatorcontrib><creatorcontrib>Kassarich, Jacob</creatorcontrib><creatorcontrib>Datko, Louis</creatorcontrib><title>Determination of Antialdosterone Activity in Normal Dogs</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
A method is described for detecting an aldosterone antagonist over a 6-hour period in the unanesthetized intact dog. The method is based upon the ability of an aldosterone antagonist to overcome the depressed urinary Na/K ratio caused by administration of the potent mineralocorticoid 9 α-fluorohydrocortisone. Using this procedure, it was shown that spironolactone-A is active at an oral dose as low as 3 mg/kg, and at 12 mg/kg has a significant natriuretic effect.</description><subject>Animals</subject><subject>Body Fluids</subject><subject>Chlorides</subject><subject>Dogs</subject><subject>Fludrocortisone</subject><subject>Mineralocorticoid Receptor Antagonists</subject><subject>Natriuresis</subject><subject>Old Medline</subject><subject>Pharmacology</subject><subject>Potassium</subject><subject>Spironolactone</subject><subject>Urine</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyxQVuxCPXb9WlYtL6mCDawtN5lUrpK42AkSf09Ki9ixGunq3CvNIeQa6B0HDVNKuTKKqRxA58wYpU7IGAQXOZfGnJLxHsj3xIhcpLSlFIRi8pyMYMbkTEgxJnqJHcbGt67zoc1Clc3bzru6DGnIQ4vZvOj8p---Mt9mLyE2rs6WYZMuyVnl6oRXxzsh7w_3b4unfPX6-LyYr_KCGdblosKyZNpVGrlz0nAGhYK1Kl2FM6apZIIqJzkVILSS5Uw6BKbLwhmOa9R8Qm4Pu7sYPnpMnW18KrCuXYuhT1ZzYwQYGEB2AIsYUopY2V30jYtfFqjd-7K_vuzgy_74Gko3x_V-3WD5VzkKGoDpAUhug3Yb-tgO3_43-Q2qWnL4</recordid><startdate>196503</startdate><enddate>196503</enddate><creator>Rosenthale, Marvin E.</creator><creator>Schneider, Fred</creator><creator>Kassarich, Jacob</creator><creator>Datko, Louis</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196503</creationdate><title>Determination of Antialdosterone Activity in Normal Dogs</title><author>Rosenthale, Marvin E. ; Schneider, Fred ; Kassarich, Jacob ; Datko, Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-5fedd28af8e3aa69321c71b7dafe428062507a630515876d46ae128dca93ebe83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Animals</topic><topic>Body Fluids</topic><topic>Chlorides</topic><topic>Dogs</topic><topic>Fludrocortisone</topic><topic>Mineralocorticoid Receptor Antagonists</topic><topic>Natriuresis</topic><topic>Old Medline</topic><topic>Pharmacology</topic><topic>Potassium</topic><topic>Spironolactone</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenthale, Marvin E.</creatorcontrib><creatorcontrib>Schneider, Fred</creatorcontrib><creatorcontrib>Kassarich, Jacob</creatorcontrib><creatorcontrib>Datko, Louis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenthale, Marvin E.</au><au>Schneider, Fred</au><au>Kassarich, Jacob</au><au>Datko, Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Antialdosterone Activity in Normal Dogs</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1965-03</date><risdate>1965</risdate><volume>118</volume><issue>3</issue><spage>806</spage><epage>809</epage><pages>806-809</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
A method is described for detecting an aldosterone antagonist over a 6-hour period in the unanesthetized intact dog. The method is based upon the ability of an aldosterone antagonist to overcome the depressed urinary Na/K ratio caused by administration of the potent mineralocorticoid 9 α-fluorohydrocortisone. Using this procedure, it was shown that spironolactone-A is active at an oral dose as low as 3 mg/kg, and at 12 mg/kg has a significant natriuretic effect.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>14264565</pmid><doi>10.3181/00379727-118-29977</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1965-03, Vol.118 (3), p.806-809 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83995191 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Body Fluids Chlorides Dogs Fludrocortisone Mineralocorticoid Receptor Antagonists Natriuresis Old Medline Pharmacology Potassium Spironolactone Urine |
| title | Determination of Antialdosterone Activity in Normal Dogs |
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