Correlation between gestational age, weight, or ponderosity and serum thyroxine concentration at birth
Thyroxine levels were measured in cord blood sera from 2,180 healthy infants born of “low-risk” mothers in Los Angeles. Variations of T 4 with gestational age, birth weight, ponderosity (size related to weight), sex, and race were studied, as well as the variation of W and P with GA. Over the range...
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| Veröffentlicht in: | The Journal of pediatrics 1977-08, Vol.91 (2), p.199-203 |
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| container_title | The Journal of pediatrics |
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| creator | Bernard, Betty Oddie, T.H. Fisher, Delbert A. |
| description | Thyroxine levels were measured in cord blood sera from 2,180 healthy infants born of “low-risk” mothers in Los Angeles. Variations of T
4 with gestational age, birth weight, ponderosity (size related to weight), sex, and race were studied, as well as the variation of W and P with GA. Over the range of GA 30 to 47 weeks, serum T
4 concentrations, W, and P each increase with GA, leveling off to approximately constant values from 42 to 47 weeks; the increases are 12, 66, and 20%, respectively. For a fixed GA, T
1 increases with increasing W but is not correlated with P; W, GA, and their product are useful measurements for predicting T
4, but P is not. Formulas for predicting cord T
4 are given for possible use in improving computer-assisted screening programs for congenital hypothyroidism; mean T
4 values (±2 SD) are tabulated against W and GA. |
| doi_str_mv | 10.1016/S0022-3476(77)80812-3 |
| format | Article |
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4 with gestational age, birth weight, ponderosity (size related to weight), sex, and race were studied, as well as the variation of W and P with GA. Over the range of GA 30 to 47 weeks, serum T
4 concentrations, W, and P each increase with GA, leveling off to approximately constant values from 42 to 47 weeks; the increases are 12, 66, and 20%, respectively. For a fixed GA, T
1 increases with increasing W but is not correlated with P; W, GA, and their product are useful measurements for predicting T
4, but P is not. Formulas for predicting cord T
4 are given for possible use in improving computer-assisted screening programs for congenital hypothyroidism; mean T
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4 with gestational age, birth weight, ponderosity (size related to weight), sex, and race were studied, as well as the variation of W and P with GA. Over the range of GA 30 to 47 weeks, serum T
4 concentrations, W, and P each increase with GA, leveling off to approximately constant values from 42 to 47 weeks; the increases are 12, 66, and 20%, respectively. For a fixed GA, T
1 increases with increasing W but is not correlated with P; W, GA, and their product are useful measurements for predicting T
4, but P is not. Formulas for predicting cord T
4 are given for possible use in improving computer-assisted screening programs for congenital hypothyroidism; mean T
4 values (±2 SD) are tabulated against W and GA.</description><subject>Birth Weight</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Sex Factors</subject><subject>Thyroxine - blood</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS3EqxT-ACSvEEgN2HUSOyuEKl5SJRbA2nKcSWuUxsV2KP173KZiy2o0M3fu6B6ELii5oYTmt2-EjMcJS3l-xfm1IILGbg8NKCl4kgvG9tHgT3KMTrz_JIQUKSFH6FDwNOf5ANUT6xw0Khjb4hLCCqDFM_BhO1ENVjMY4RWY2TyMsHV4adsKnPUmrLFqK-zBdQsc5mtnf0wLWNtWQxtc76gCLo0L81N0UKvGw9muDtHH48P75DmZvj69TO6niWZZERJaZUIpVpY6SwnnHPg4JWMQvIhdQRit8jLTdZbVtBYpZSCqtAaWa00ypXLNhuiy9106-9XFGHJhvIamUS3YzkvBimjGeRRmvVDHLN5BLZfOLJRbS0rkBq_c4pUbdpJzucUrWbw73z3oygVUf1c9z7i-69cQQ34bcNJrA5FIZRzoICtr_nnwC46Vi5E</recordid><startdate>197708</startdate><enddate>197708</enddate><creator>Bernard, Betty</creator><creator>Oddie, T.H.</creator><creator>Fisher, Delbert A.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197708</creationdate><title>Correlation between gestational age, weight, or ponderosity and serum thyroxine concentration at birth</title><author>Bernard, Betty ; Oddie, T.H. ; Fisher, Delbert A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-1d58aa3bbc540777e72402e8790779031d6b5cf55f1f8413e8d4fe36cc05aa6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Birth Weight</topic><topic>Ethnic Groups</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Sex Factors</topic><topic>Thyroxine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernard, Betty</creatorcontrib><creatorcontrib>Oddie, T.H.</creatorcontrib><creatorcontrib>Fisher, Delbert A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernard, Betty</au><au>Oddie, T.H.</au><au>Fisher, Delbert A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between gestational age, weight, or ponderosity and serum thyroxine concentration at birth</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1977-08</date><risdate>1977</risdate><volume>91</volume><issue>2</issue><spage>199</spage><epage>203</epage><pages>199-203</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Thyroxine levels were measured in cord blood sera from 2,180 healthy infants born of “low-risk” mothers in Los Angeles. Variations of T
4 with gestational age, birth weight, ponderosity (size related to weight), sex, and race were studied, as well as the variation of W and P with GA. Over the range of GA 30 to 47 weeks, serum T
4 concentrations, W, and P each increase with GA, leveling off to approximately constant values from 42 to 47 weeks; the increases are 12, 66, and 20%, respectively. For a fixed GA, T
1 increases with increasing W but is not correlated with P; W, GA, and their product are useful measurements for predicting T
4, but P is not. Formulas for predicting cord T
4 are given for possible use in improving computer-assisted screening programs for congenital hypothyroidism; mean T
4 values (±2 SD) are tabulated against W and GA.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>874676</pmid><doi>10.1016/S0022-3476(77)80812-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1977-08, Vol.91 (2), p.199-203 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Birth Weight Ethnic Groups Female Gestational Age Humans Infant, Newborn Male Sex Factors Thyroxine - blood |
| title | Correlation between gestational age, weight, or ponderosity and serum thyroxine concentration at birth |
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