Spontaneous Leprosy-Like Disease in a Chimpanzee
The clinical and laboratory findings of a spontaneous disease, resembling human leprosy, in a chimpanzee are described. The disease was a chronic progressive dermatitis characterized by nodular thickenings of the dermis and involving the ears, eyebrows, nostrils, and lips. A maculopapular rash was a...
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| Veröffentlicht in: | The Journal of infectious diseases 1977-07, Vol.136 (1), p.132-136 |
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| container_title | The Journal of infectious diseases |
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| creator | Donham, Kelley J. Leininger, Joel R. |
| description | The clinical and laboratory findings of a spontaneous disease, resembling human leprosy, in a chimpanzee are described. The disease was a chronic progressive dermatitis characterized by nodular thickenings of the dermis and involving the ears, eyebrows, nostrils, and lips. A maculopapular rash was also present. Numerous acid-fast organisms were found in nasal swabs and in dermal lesions, including nerves. Attempts to culture acid-fast organisms in artificial media have failed. At this time, the only features of the etiologic agent of this disease that are inconsistent with those of Mycobacterium leprae are failure of the organisms to oxidize 3, 4-dihydroxyphenylalanine and failure of pyridine to remove the acid-fast staining property of the bacilli. |
| doi_str_mv | 10.1093/infdis/136.1.132 |
| format | Article |
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The disease was a chronic progressive dermatitis characterized by nodular thickenings of the dermis and involving the ears, eyebrows, nostrils, and lips. A maculopapular rash was also present. Numerous acid-fast organisms were found in nasal swabs and in dermal lesions, including nerves. Attempts to culture acid-fast organisms in artificial media have failed. At this time, the only features of the etiologic agent of this disease that are inconsistent with those of Mycobacterium leprae are failure of the organisms to oxidize 3, 4-dihydroxyphenylalanine and failure of pyridine to remove the acid-fast staining property of the bacilli.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/136.1.132</identifier><identifier>PMID: 886203</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Animals ; Humans ; Inoculation ; Lepromin ; Leprosy ; Leprosy - etiology ; Leprosy - microbiology ; Leprosy - veterinary ; Lesions ; Male ; Mycobacterium leprae ; Nervous system diseases ; Pan troglodytes ; Pyridines ; Tuberculin ; Tuberculosis</subject><ispartof>The Journal of infectious diseases, 1977-07, Vol.136 (1), p.132-136</ispartof><rights>Copyright 1977 University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1060f0da40146b7af4fd9089230a53e6c97ce857e2e5498efcc95f6bf07853e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30106450$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30106450$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/886203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donham, Kelley J.</creatorcontrib><creatorcontrib>Leininger, Joel R.</creatorcontrib><title>Spontaneous Leprosy-Like Disease in a Chimpanzee</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The clinical and laboratory findings of a spontaneous disease, resembling human leprosy, in a chimpanzee are described. 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At this time, the only features of the etiologic agent of this disease that are inconsistent with those of Mycobacterium leprae are failure of the organisms to oxidize 3, 4-dihydroxyphenylalanine and failure of pyridine to remove the acid-fast staining property of the bacilli.</description><subject>Animals</subject><subject>Humans</subject><subject>Inoculation</subject><subject>Lepromin</subject><subject>Leprosy</subject><subject>Leprosy - etiology</subject><subject>Leprosy - microbiology</subject><subject>Leprosy - veterinary</subject><subject>Lesions</subject><subject>Male</subject><subject>Mycobacterium leprae</subject><subject>Nervous system diseases</subject><subject>Pan troglodytes</subject><subject>Pyridines</subject><subject>Tuberculin</subject><subject>Tuberculosis</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPwzAQhC3EqxTuHEDKiVvadZz4cYQWKFIlJN7iYrnJWrht0hCnEuXXY5Sql93DN7OaHULOKQwoKDZ0lS2cH1LGB3RAWbJHejRjIuacsn3SA0iSmEqljsmJ93MASBkXR-RQSp4A6xF4rldVaypcrX00xbpZ-U08dQuMxs6j8Ri5KjLR6MuVtal-EU_JgTVLj2fb3Sevd7cvo0k8fbx_GF1P45xlrI0pcLBQmBRoymfC2NQWCqRKGJiMIc-VyFFmAhPMUiXR5rnKLJ9ZEDJwyvrkqrsbIn2v0be6dD7H5bLLqiVTUgBVQQidMA_ZfYNW140rTbPRFPR_R7rrSIeONA0zCZaL7e31rMRiZ-hKCfiyw3PfrpodZRCeSjMIPO648y3-7LhpFpoLJjI9-fjUSiXj9xv-pN_YH7LpetU</recordid><startdate>197707</startdate><enddate>197707</enddate><creator>Donham, Kelley J.</creator><creator>Leininger, Joel R.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197707</creationdate><title>Spontaneous Leprosy-Like Disease in a Chimpanzee</title><author>Donham, Kelley J. ; Leininger, Joel R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1060f0da40146b7af4fd9089230a53e6c97ce857e2e5498efcc95f6bf07853e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Humans</topic><topic>Inoculation</topic><topic>Lepromin</topic><topic>Leprosy</topic><topic>Leprosy - etiology</topic><topic>Leprosy - microbiology</topic><topic>Leprosy - veterinary</topic><topic>Lesions</topic><topic>Male</topic><topic>Mycobacterium leprae</topic><topic>Nervous system diseases</topic><topic>Pan troglodytes</topic><topic>Pyridines</topic><topic>Tuberculin</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donham, Kelley J.</creatorcontrib><creatorcontrib>Leininger, Joel R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donham, Kelley J.</au><au>Leininger, Joel R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous Leprosy-Like Disease in a Chimpanzee</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1977-07</date><risdate>1977</risdate><volume>136</volume><issue>1</issue><spage>132</spage><epage>136</epage><pages>132-136</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>The clinical and laboratory findings of a spontaneous disease, resembling human leprosy, in a chimpanzee are described. 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| ispartof | The Journal of infectious diseases, 1977-07, Vol.136 (1), p.132-136 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83987019 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Humans Inoculation Lepromin Leprosy Leprosy - etiology Leprosy - microbiology Leprosy - veterinary Lesions Male Mycobacterium leprae Nervous system diseases Pan troglodytes Pyridines Tuberculin Tuberculosis |
| title | Spontaneous Leprosy-Like Disease in a Chimpanzee |
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