Childhood pheochromocytoma: treatment with alpha methyl tyrosine for resistant hypertension
A 12-year-old boy with a norepinephrine-secreting pheochromocytoma that caused hypertension resistant to oral alpha adrenergic blockade is reported. Resistance to alpha adrenergic blocking agents developed when the patient's daily propranolol dosage was lowered from 10 to 1 mg/kg. Subsequently,...
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| Veröffentlicht in: | The Journal of pediatrics 1977-07, Vol.91 (1), p.143-147 |
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| container_title | The Journal of pediatrics |
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| creator | Robinson, R G DeQuattro, V Grushkin, C M Lieberman, E |
| description | A 12-year-old boy with a norepinephrine-secreting pheochromocytoma that caused hypertension resistant to oral alpha adrenergic blockade is reported. Resistance to alpha adrenergic blocking agents developed when the patient's daily propranolol dosage was lowered from 10 to 1 mg/kg. Subsequently, alpha methyl tyrosine, an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, controlled the patient's blood pressure and was associated with reduction in total urinary catecholamine excretion. Norepinephrine content of the tumor and uninvolved adrenal gland removal at surgery was reduced. These findings confirm that alpha methyl tyrosine inhibited in vivo synthesis of catecholamines. |
| doi_str_mv | 10.1016/S0022-3476(77)80467-8 |
| format | Article |
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Resistance to alpha adrenergic blocking agents developed when the patient's daily propranolol dosage was lowered from 10 to 1 mg/kg. Subsequently, alpha methyl tyrosine, an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, controlled the patient's blood pressure and was associated with reduction in total urinary catecholamine excretion. Norepinephrine content of the tumor and uninvolved adrenal gland removal at surgery was reduced. 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Resistance to alpha adrenergic blocking agents developed when the patient's daily propranolol dosage was lowered from 10 to 1 mg/kg. Subsequently, alpha methyl tyrosine, an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, controlled the patient's blood pressure and was associated with reduction in total urinary catecholamine excretion. Norepinephrine content of the tumor and uninvolved adrenal gland removal at surgery was reduced. These findings confirm that alpha methyl tyrosine inhibited in vivo synthesis of catecholamines.</description><subject>Adrenal Gland Neoplasms - complications</subject><subject>Adrenal Gland Neoplasms - metabolism</subject><subject>Catecholamines - urine</subject><subject>Child</subject><subject>Drug Combinations</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - etiology</subject><subject>Male</subject><subject>Methyltyrosines - pharmacology</subject><subject>Methyltyrosines - therapeutic use</subject><subject>Phenoxybenzamine - therapeutic use</subject><subject>Pheochromocytoma - complications</subject><subject>Pheochromocytoma - metabolism</subject><subject>Propranolol - therapeutic use</subject><subject>Tyrosine 3-Monooxygenase - antagonists & inhibitors</subject><issn>0022-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90M1KxDAUBeAsHHQcfQIRshJdVG-TtkncSfEPBlyoKxclTW9JpW1qkkH69hYdXF04fBwOl5DzFK5TSIubVwDGEp6J4lKIKwlZIRJ5QNb_8RE5DuETAFQGcEhWqShytSYfpe36xjrX0MmiM9a7wZk5ukHf0uhRxwHHSL-7aKnuJ6vpgNHOPY2zd6EbkbbOU4-hC1Ev0M4T-ohj6Nx4Qlat7gOe7u-GvD_cv5VPyfbl8bm82yYTgywmmOVSasGZFMtYwwyCaoFp0CZXImu5YDnPayg0l0Yx1jQtr1XNmkWoOs34hlz89U7efe0wxGrogsG-1yO6XagkVyJXuVzg2R7u6gGbavLdoP1c_f6C_wDxaWF3</recordid><startdate>197707</startdate><enddate>197707</enddate><creator>Robinson, R G</creator><creator>DeQuattro, V</creator><creator>Grushkin, C M</creator><creator>Lieberman, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197707</creationdate><title>Childhood pheochromocytoma: treatment with alpha methyl tyrosine for resistant hypertension</title><author>Robinson, R G ; DeQuattro, V ; Grushkin, C M ; Lieberman, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p204t-e4588a73287022c2ce09f02a0ac5974f372535b06a38c922ddf3b9b2da0a9b143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adrenal Gland Neoplasms - complications</topic><topic>Adrenal Gland Neoplasms - metabolism</topic><topic>Catecholamines - urine</topic><topic>Child</topic><topic>Drug Combinations</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - etiology</topic><topic>Male</topic><topic>Methyltyrosines - pharmacology</topic><topic>Methyltyrosines - therapeutic use</topic><topic>Phenoxybenzamine - therapeutic use</topic><topic>Pheochromocytoma - complications</topic><topic>Pheochromocytoma - metabolism</topic><topic>Propranolol - therapeutic use</topic><topic>Tyrosine 3-Monooxygenase - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, R G</creatorcontrib><creatorcontrib>DeQuattro, V</creatorcontrib><creatorcontrib>Grushkin, C M</creatorcontrib><creatorcontrib>Lieberman, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinson, R G</au><au>DeQuattro, V</au><au>Grushkin, C M</au><au>Lieberman, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Childhood pheochromocytoma: treatment with alpha methyl tyrosine for resistant hypertension</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1977-07</date><risdate>1977</risdate><volume>91</volume><issue>1</issue><spage>143</spage><epage>147</epage><pages>143-147</pages><issn>0022-3476</issn><abstract>A 12-year-old boy with a norepinephrine-secreting pheochromocytoma that caused hypertension resistant to oral alpha adrenergic blockade is reported. Resistance to alpha adrenergic blocking agents developed when the patient's daily propranolol dosage was lowered from 10 to 1 mg/kg. Subsequently, alpha methyl tyrosine, an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, controlled the patient's blood pressure and was associated with reduction in total urinary catecholamine excretion. Norepinephrine content of the tumor and uninvolved adrenal gland removal at surgery was reduced. These findings confirm that alpha methyl tyrosine inhibited in vivo synthesis of catecholamines.</abstract><cop>United States</cop><pmid>17659</pmid><doi>10.1016/S0022-3476(77)80467-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1977-07, Vol.91 (1), p.143-147 |
| issn | 0022-3476 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenal Gland Neoplasms - complications Adrenal Gland Neoplasms - metabolism Catecholamines - urine Child Drug Combinations Humans Hypertension - drug therapy Hypertension - etiology Male Methyltyrosines - pharmacology Methyltyrosines - therapeutic use Phenoxybenzamine - therapeutic use Pheochromocytoma - complications Pheochromocytoma - metabolism Propranolol - therapeutic use Tyrosine 3-Monooxygenase - antagonists & inhibitors |
| title | Childhood pheochromocytoma: treatment with alpha methyl tyrosine for resistant hypertension |
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