Effects of IL-13 on Mucociliary Differentiation of Pediatric Asthmatic Bronchial Epithelial Cells

Goblet cell hyperplasia (GCH) and decreased ciliated cells are characteristic of asthma. We examined the effects of IL-13 (2 and 20 ng/mL) on in vitro mucociliary differentiation in pediatric bronchial epithelial cells (PBECs) of normal PBEC [PBEC(N)] and asthmatic PBEC [PBEC(A)] children. Markers o...

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Veröffentlicht in:	Pediatric research 2011-02, Vol.69 (2), p.95-100
Hauptverfasser:	Thavagnanam, Surendran, Parker, Jeremy C, McBrien, Michael E, Skibinski, Grzegorz, Heaney, Liam G, Shields, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/249/2510/31 692/700/1720 Asthma - immunology Asthma - metabolism Asthma - pathology basic-science-investigation Biological and medical sciences Bronchi - immunology Bronchi - metabolism Bronchi - pathology Case-Control Studies Cell Differentiation Cells, Cultured Child Child, Preschool Chronic obstructive pulmonary disease, asthma Cilia - immunology Cilia - pathology Electric Impedance Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique General aspects Goblet Cells - immunology Goblet Cells - metabolism Goblet Cells - pathology Humans Interleukin-13 - metabolism Medical sciences Medicine Medicine & Public Health Microscopy, Confocal Mucin 5AC - genetics Mucin 5AC - metabolism Mucociliary Clearance Pediatric Surgery Pediatrics Phenotype Pneumology Polymerase Chain Reaction Recombinant Proteins - metabolism Up-Regulation
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