Finding Reaction Pathways for Multicomponent Reactions: The Passerini Reaction is a Four-Component Reaction
Route finder: The Passerini three‐component reaction of a carboxylic acid, an aldehyde (or ketone), and an isocyanide to give an α‐acyloxycarboxamide actually follows a four‐component mechanism involving an additional molecule of carboxylic acid (see scheme). The discovery was made by applying a new...
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Veröffentlicht in: | Angewandte Chemie International Edition 2011-01, Vol.50 (3), p.644-649 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Route finder: The Passerini three‐component reaction of a carboxylic acid, an aldehyde (or ketone), and an isocyanide to give an α‐acyloxycarboxamide actually follows a four‐component mechanism involving an additional molecule of carboxylic acid (see scheme). The discovery was made by applying a new “reaction route explorer” to the simplest Passerini reaction (HCOOH+HCHO+CH3NC). |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201005336 |