Challenges Associated with Regeneration of Orbital Floor Bone
Orbital floor fractures are a serious consequence of craniofacial trauma and account for ∼60%–70% of all orbital fractures. Unfortunately, the body's natural response to orbital floor defects generally may not restore proper function and facial aesthetics, which is complicated by the thin bone...
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| Veröffentlicht in: | Tissue engineering. Part B, Reviews Reviews, 2010-10, Vol.16 (5), p.541-550 |
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| creator | Betz, Martha W. Caccamese, John F. Coletti, Domenick P. Sauk, John J. Fisher, John P. |
| description | Orbital floor fractures are a serious consequence of craniofacial trauma and account for ∼60%–70% of all orbital fractures. Unfortunately, the body's natural response to orbital floor defects generally may not restore proper function and facial aesthetics, which is complicated by the thin bone and adjacent sinuses. Current clinical treatments include alloplastic implants and autologous grafts; however, each has associated disadvantages and sequelae. This review has outlined necessary components for a successful tissue-engineered construct for orbital floor repair. In addition, current successes and progress in the literature specific to orbital floors and craniofacial research have been reviewed. Finally, challenges and future directions have been described. |
| doi_str_mv | 10.1089/ten.teb.2009.0393 |
| format | Article |
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Unfortunately, the body's natural response to orbital floor defects generally may not restore proper function and facial aesthetics, which is complicated by the thin bone and adjacent sinuses. Current clinical treatments include alloplastic implants and autologous grafts; however, each has associated disadvantages and sequelae. This review has outlined necessary components for a successful tissue-engineered construct for orbital floor repair. In addition, current successes and progress in the literature specific to orbital floors and craniofacial research have been reviewed. 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Finally, challenges and future directions have been described.</description><subject>Analysis</subject><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Bone Regeneration</subject><subject>Care and treatment</subject><subject>Deformations (Mechanics)</subject><subject>Humans</subject><subject>Orbital Fractures - surgery</subject><subject>Prostheses and Implants</subject><subject>Tissue Engineering</subject><subject>Tomography</subject><subject>Wound Healing</subject><subject>Wounds and injuries</subject><issn>1937-3368</issn><issn>1937-3376</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkV1rFDEYhYMo9kN_gDcy6IVXO83H5OvCi3WxKhQKRa9DZubNNiWb1CSL9N-bYWtBEVpCSDg855C8B6E3BPcEK31WIfYVxp5irHvMNHuGjolmcsWYFM8f7kIdoZNSbjAWWEj1Eh1RLAaupD5GHzfXNgSIWyjdupQ0eVth7n75et1dwRYiZFt9il1y3WUefbWhOw8p5e5TivAKvXA2FHh9f56iH-efv2--ri4uv3zbrC9W0yCHutJ8ZMpiPU_DqCWTmlpuBzeMnDs5Y1AT57OzTQaqKDhqBRFYOgDM1KwcO0UfDrm3Of3cQ6lm58sEIdgIaV-MYlpiNlD-KCk5HzBvM2nku3_Im7TPsX2jQUwQJQhp0PsDtLUBjI8u1WynJdKsKVNUUkxYo_r_UG3NsPNTm5PzTf_LQA6GKadSMjhzm_3O5jtDsFmqNa3atkezVGuWapvn7f179-MO5gfHny4bIA_AItsYg4cRcn1C9G_fd7Bb</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Betz, Martha W.</creator><creator>Caccamese, John F.</creator><creator>Coletti, Domenick P.</creator><creator>Sauk, John J.</creator><creator>Fisher, John P.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20101001</creationdate><title>Challenges Associated with Regeneration of Orbital Floor Bone</title><author>Betz, Martha W. ; 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| ispartof | Tissue engineering. Part B, Reviews, 2010-10, Vol.16 (5), p.541-550 |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Analysis Anatomy & physiology Animals Biocompatible Materials Bone Regeneration Care and treatment Deformations (Mechanics) Humans Orbital Fractures - surgery Prostheses and Implants Tissue Engineering Tomography Wound Healing Wounds and injuries |
| title | Challenges Associated with Regeneration of Orbital Floor Bone |
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