Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency
Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested to be a possible cause of multiple sclerosis (MS). If the presumed mechanism of venous stasis-related parenchymal iron deposition and neurodegeneration were true, then upregulation of intrathecal iron transport proteins may be exp...
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| Veröffentlicht in: | Neurology 2010-11, Vol.75 (18), p.1617-1622 |
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| creator | WORTHINGTON, V KILLESTEIN, J EIKELENBOOM, M. J TEUNISSEN, C. E BARKHOF, F POLMAN, C. H UITDEHAAG, B. M. J PETZOLD, A |
| description | Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested to be a possible cause of multiple sclerosis (MS). If the presumed mechanism of venous stasis-related parenchymal iron deposition and neurodegeneration were true, then upregulation of intrathecal iron transport proteins may be expected.
This was a cross-sectional (n = 1,408) and longitudinal (n = 29) study on CSF ferritin levels in patients with MS and a range of neurologic disorders.
Pathologic (>12 ng/mL) CSF ferritin levels were observed in 4% of the control patients (median 4 ng/mL), 91% of patients with superficial siderosis (75 ng/mL), 73% of patients with a subarachnoid hemorrhage (59 ng/mL), 10% of patients with relapsing-remitting MS (5 ng/mL), 11% of patients with primary progressive MS (6 ng/mL), 23% of patients with secondary progressive MS (5 ng/mL), and 23% of patients with meningoencephalitis (5 ng/mL). In MS, there was no significant change of CSF ferritin levels over the 3-year follow-up period.
These data do not support an etiologic role for CCSVI-related parenchymal iron deposition in MS. |
| doi_str_mv | 10.1212/WNL.0b013e3181fb449e |
| format | Article |
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This was a cross-sectional (n = 1,408) and longitudinal (n = 29) study on CSF ferritin levels in patients with MS and a range of neurologic disorders.
Pathologic (>12 ng/mL) CSF ferritin levels were observed in 4% of the control patients (median 4 ng/mL), 91% of patients with superficial siderosis (75 ng/mL), 73% of patients with a subarachnoid hemorrhage (59 ng/mL), 10% of patients with relapsing-remitting MS (5 ng/mL), 11% of patients with primary progressive MS (6 ng/mL), 23% of patients with secondary progressive MS (5 ng/mL), and 23% of patients with meningoencephalitis (5 ng/mL). In MS, there was no significant change of CSF ferritin levels over the 3-year follow-up period.
These data do not support an etiologic role for CCSVI-related parenchymal iron deposition in MS.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0b013e3181fb449e</identifier><identifier>PMID: 20881272</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Cohort Studies ; Cross-Sectional Studies ; Disability Evaluation ; Enzyme-Linked Immunosorbent Assay - methods ; Female ; Ferritins - cerebrospinal fluid ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - cerebrospinal fluid ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Statistics as Topic ; Venous Insufficiency - diagnosis ; Venous Insufficiency - etiology</subject><ispartof>Neurology, 2010-11, Vol.75 (18), p.1617-1622</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-c5f10b31d169b2213c599439044ac08fc360e79adfff0f7cff95147d8cc287373</citedby><cites>FETCH-LOGICAL-c368t-c5f10b31d169b2213c599439044ac08fc360e79adfff0f7cff95147d8cc287373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23423291$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20881272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WORTHINGTON, V</creatorcontrib><creatorcontrib>KILLESTEIN, J</creatorcontrib><creatorcontrib>EIKELENBOOM, M. J</creatorcontrib><creatorcontrib>TEUNISSEN, C. E</creatorcontrib><creatorcontrib>BARKHOF, F</creatorcontrib><creatorcontrib>POLMAN, C. H</creatorcontrib><creatorcontrib>UITDEHAAG, B. M. J</creatorcontrib><creatorcontrib>PETZOLD, A</creatorcontrib><title>Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency</title><title>Neurology</title><addtitle>Neurology</addtitle><description>Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested to be a possible cause of multiple sclerosis (MS). If the presumed mechanism of venous stasis-related parenchymal iron deposition and neurodegeneration were true, then upregulation of intrathecal iron transport proteins may be expected.
This was a cross-sectional (n = 1,408) and longitudinal (n = 29) study on CSF ferritin levels in patients with MS and a range of neurologic disorders.
Pathologic (>12 ng/mL) CSF ferritin levels were observed in 4% of the control patients (median 4 ng/mL), 91% of patients with superficial siderosis (75 ng/mL), 73% of patients with a subarachnoid hemorrhage (59 ng/mL), 10% of patients with relapsing-remitting MS (5 ng/mL), 11% of patients with primary progressive MS (6 ng/mL), 23% of patients with secondary progressive MS (5 ng/mL), and 23% of patients with meningoencephalitis (5 ng/mL). In MS, there was no significant change of CSF ferritin levels over the 3-year follow-up period.
These data do not support an etiologic role for CCSVI-related parenchymal iron deposition in MS.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Disability Evaluation</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Female</subject><subject>Ferritins - cerebrospinal fluid</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Statistics as Topic</subject><subject>Venous Insufficiency - diagnosis</subject><subject>Venous Insufficiency - etiology</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LAzEQhoMotn78A5FcxNPWfO0mOUqxKtR6UNHbkk2TGkk3NdkV-u9NsSp48TQzzPPODPMCcILRCBNMLp5n0xFqEKaGYoFtw5g0O2CIS1IVFSUvu2CIEBEFFVwMwEFKbwjlJpf7YECQEJhwMgT1LMSl8nD8MIHWxOg610JvPoxPMGd3DzD1i4VJHVQL5docTeeCDwunYQzewGChfo2hzfWHaUO_kaXeWqedafX6COxZ5ZM53sZD8DS5ehzfFNP769vx5bTQtBJdoUuLUUPxHFeyIQRTXUrJqESMKY2EzRQyXKq5tRZZrq2VJWZ8LrQmglNOD8H519xVDO99vrdeuqSN96o1-ahaUFlJxgn7l-QVIbxEDGeSfZE6hpSisfUquqWK6xqjeuNBnT2o_3qQZafbBX2zNPMf0ffTM3C2BVTSytuoWu3SL0cZoURi-gkTVpDB</recordid><startdate>20101102</startdate><enddate>20101102</enddate><creator>WORTHINGTON, V</creator><creator>KILLESTEIN, J</creator><creator>EIKELENBOOM, M. 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J ; PETZOLD, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-c5f10b31d169b2213c599439044ac08fc360e79adfff0f7cff95147d8cc287373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Disability Evaluation</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Female</topic><topic>Ferritins - cerebrospinal fluid</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Statistics as Topic</topic><topic>Venous Insufficiency - diagnosis</topic><topic>Venous Insufficiency - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WORTHINGTON, V</creatorcontrib><creatorcontrib>KILLESTEIN, J</creatorcontrib><creatorcontrib>EIKELENBOOM, M. J</creatorcontrib><creatorcontrib>TEUNISSEN, C. E</creatorcontrib><creatorcontrib>BARKHOF, F</creatorcontrib><creatorcontrib>POLMAN, C. H</creatorcontrib><creatorcontrib>UITDEHAAG, B. M. 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J</au><au>PETZOLD, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2010-11-02</date><risdate>2010</risdate><volume>75</volume><issue>18</issue><spage>1617</spage><epage>1622</epage><pages>1617-1622</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested to be a possible cause of multiple sclerosis (MS). If the presumed mechanism of venous stasis-related parenchymal iron deposition and neurodegeneration were true, then upregulation of intrathecal iron transport proteins may be expected.
This was a cross-sectional (n = 1,408) and longitudinal (n = 29) study on CSF ferritin levels in patients with MS and a range of neurologic disorders.
Pathologic (>12 ng/mL) CSF ferritin levels were observed in 4% of the control patients (median 4 ng/mL), 91% of patients with superficial siderosis (75 ng/mL), 73% of patients with a subarachnoid hemorrhage (59 ng/mL), 10% of patients with relapsing-remitting MS (5 ng/mL), 11% of patients with primary progressive MS (6 ng/mL), 23% of patients with secondary progressive MS (5 ng/mL), and 23% of patients with meningoencephalitis (5 ng/mL). In MS, there was no significant change of CSF ferritin levels over the 3-year follow-up period.
These data do not support an etiologic role for CCSVI-related parenchymal iron deposition in MS.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20881272</pmid><doi>10.1212/WNL.0b013e3181fb449e</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Cohort Studies Cross-Sectional Studies Disability Evaluation Enzyme-Linked Immunosorbent Assay - methods Female Ferritins - cerebrospinal fluid Humans Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Multiple Sclerosis - cerebrospinal fluid Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Statistics as Topic Venous Insufficiency - diagnosis Venous Insufficiency - etiology |
| title | Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency |
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