Hereditary tyrosinemia type 1 metabolites impair DNA excision repair pathways

► Succinylacetone (SA) and p-hydroxyphenylpyruvate (pHPPA) accumulate in HT1. ► SA and pHPPA impair base- and nucleotide excision repair. ► Base excision repair more affected than nucleotide excision repair. Hereditary tyrosinemia type 1 is an autosomal recessive metabolic disorder, which is caused...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-10, Vol.401 (1), p.32-36
Hauptverfasser:	van Dyk, E., Steenkamp, A., Koekemoer, G., Pretorius, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base excision repair Cell Line Comet Assay DNA Repair Heptanoates - metabolism Hereditary tyrosinemia Humans Hydrogen Peroxide - toxicity Nucleotide excision repair Phenylpyruvic Acids - metabolism Tyrosinemias - genetics Tyrosinemias - metabolism
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