Inhibition of Carboplatin-Induced DNA Interstrand Cross-link Repair by Gemcitabine in Patients Receiving these Drugs for Platinum-Resistant Ovarian Cancer

The potential of gemcitabine to interact with carboplatin was explored in a phase II trial in platinum-resistant ovarian cancer. Peripheral blood lymphocytes were sampled after drug administration to measure DNA interstrand cross-link formation and repair. Forty patients received carboplatin target...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2010-10, Vol.16 (19), p.4899-4905
Hauptverfasser:	LEDERMANN, Jonathan A, GABRA, Hani, JAYSON, Gordon C, SPANSWICK, Victoria J, RUSTIN, Gordon J. S, JITLAL, Mark, JAMES, Lindsay E, HARTLEY, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Carboplatin - administration & dosage Carboplatin - antagonists & inhibitors Carboplatin - pharmacology Carboplatin - therapeutic use Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxycytidine - therapeutic use DNA Damage DNA Repair - drug effects DNA, Neoplasm - metabolism Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Female Female genital diseases Gemcitabine Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Ovarian Neoplasms - drug therapy Pharmacology. Drug treatments Platinum Compounds - pharmacology Platinum Compounds - therapeutic use Time Factors Treatment Outcome Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!