Inhibitory RNA in epilepsy: Research tools and therapeutic perspectives

Summary Since its discovery a decade ago, RNA interference (RNAi) has been developed not only into powerful experimental tools but also into promising novel therapeutics. In contrast to conventional antiepileptic drugs (AEDs) that target specific proteins such as ion channels or receptors, RNAi‐base...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2010-09, Vol.51 (9), p.1659-1668
1. Verfasser:	Boison, Detlev
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - metabolism Adenosine - therapeutic use Adenosine kinase Adenosine Kinase - drug effects Adenosine Kinase - genetics Adenosine Kinase - metabolism Animals Anticonvulsants Anticonvulsants - metabolism Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Antiepileptic agents Attention Biological and medical sciences Brain Brain - drug effects Brain - enzymology Brain - metabolism Epilepsy Epilepsy - drug therapy Epilepsy - genetics Epilepsy - therapy Gene Expression Regulation Gene therapy Genetic Therapy - methods Glia Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Ion channels Medical sciences Mice MicroRNAs - physiology Nervous system (semeiology, syndromes) Neurodegenerative diseases Neurology Neuropharmacology Pharmacology. Drug treatments RNA interference RNA Interference - physiology RNA-mediated interference RNAi Seizures
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