essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation

A cyclical control circuit composed of four master regulators drives the Caulobacter cell cycle. We report that SciP, a helix-turn-helix transcription factor, is an essential component of this circuit. SciP is cell cycle-controlled and co-conserved with the global cell cycle regulator CtrA in the α-...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-11, Vol.107 (44), p.18985-18990
Hauptverfasser:	Tan, Meng How, Kozdon, Jennifer B, Shen, Xiling, Shapiro, Lucy, McAdams, Harley H
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding sites Biological Sciences Caulobacter Caulobacter - genetics Caulobacter - metabolism Cell cycle Cell Cycle - physiology Cell cycle proteins Cells Cellular immunity Chemotaxis Circuits Daughter cells Deoxyribonucleic acid DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Feedback Flagella Gene expression Gene Expression Regulation, Bacterial - physiology Genes Growth rate Helix-Turn-Helix Motifs Promoter regions Promoters Protein Binding - physiology Regulator genes Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional regulatory elements
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