Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin

The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. The overall production of ciprofloxacin was slightly hig...

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Veröffentlicht in:	Research in veterinary science 2010-10, Vol.89 (2), p.230-235
Hauptverfasser:	Idowu, O.R., Peggins, J.O., Cullison, R., Bredow, J. von
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacokinetics Area Under Curve Beef beef cattle Blood Proteins - metabolism Cattle Cattle - blood Cattle - metabolism Chromatography Ciprofloxacin Ciprofloxacin - administration & dosage Ciprofloxacin - blood Ciprofloxacin - metabolism Ciprofloxacin - pharmacokinetics dairy cows Enrofloxacin Female Fluoroquinolones - administration & dosage Fluoroquinolones - blood Fluoroquinolones - metabolism Fluoroquinolones - pharmacokinetics Half-Life Injections, Intravenous intravenous injection Lactating cows lactation Male Pharmacokinetics Plasma Protein Binding Proteins Sex Characteristics Steers Veterinary medicine
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