Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin
The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. The overall production of ciprofloxacin was slightly hig...
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| Veröffentlicht in: | Research in veterinary science 2010-10, Vol.89 (2), p.230-235 |
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| description | The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. The overall production of ciprofloxacin was slightly higher in steers than in cows (metabolite ratio: 64% and 59%, respectively). There was no significant difference in plasma protein binding of enrofloxacin between cows (percent bound: 59.4%) and steers (percent bound: 60.8%). Ciprofloxacin was more extensively bound to plasma proteins in steers (percent bound: 49.6%) than in cows (percent bound: 33.8%). The steady state volume of distribution of enrofloxacin is comparable in cows (1.55
L/kg) and steers (1.59
L/kg). Within either bovine class, plasma elimination half-life of enrofloxacin and ciprofloxacin are comparable, while plasma protein binding was higher for enrofloxacin than for ciprofloxacin. Ciprofloxacin was more concentrated in milk than enrofloxacin. |
| doi_str_mv | 10.1016/j.rvsc.2009.12.019 |
| format | Article |
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L/kg) and steers (1.59
L/kg). Within either bovine class, plasma elimination half-life of enrofloxacin and ciprofloxacin are comparable, while plasma protein binding was higher for enrofloxacin than for ciprofloxacin. Ciprofloxacin was more concentrated in milk than enrofloxacin.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2009.12.019</identifier><identifier>PMID: 20129633</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - metabolism ; Anti-Bacterial Agents - pharmacokinetics ; Area Under Curve ; Beef ; beef cattle ; Blood Proteins - metabolism ; Cattle ; Cattle - blood ; Cattle - metabolism ; Chromatography ; Ciprofloxacin ; Ciprofloxacin - administration & dosage ; Ciprofloxacin - blood ; Ciprofloxacin - metabolism ; Ciprofloxacin - pharmacokinetics ; dairy cows ; Enrofloxacin ; Female ; Fluoroquinolones - administration & dosage ; Fluoroquinolones - blood ; Fluoroquinolones - metabolism ; Fluoroquinolones - pharmacokinetics ; Half-Life ; Injections, Intravenous ; intravenous injection ; Lactating cows ; lactation ; Male ; Pharmacokinetics ; Plasma ; Protein Binding ; Proteins ; Sex Characteristics ; Steers ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2010-10, Vol.89 (2), p.230-235</ispartof><rights>2010</rights><rights>Published by Elsevier India Pvt Ltd.</rights><rights>Copyright Elsevier Limited Oct 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-5faffa2abfd67173d2beb549e162796bf0c0cdff3df67af4f62004e221c7c0343</citedby><cites>FETCH-LOGICAL-c505t-5faffa2abfd67173d2beb549e162796bf0c0cdff3df67af4f62004e221c7c0343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2009.12.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20129633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Idowu, O.R.</creatorcontrib><creatorcontrib>Peggins, J.O.</creatorcontrib><creatorcontrib>Cullison, R.</creatorcontrib><creatorcontrib>Bredow, J. von</creatorcontrib><title>Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. The overall production of ciprofloxacin was slightly higher in steers than in cows (metabolite ratio: 64% and 59%, respectively). There was no significant difference in plasma protein binding of enrofloxacin between cows (percent bound: 59.4%) and steers (percent bound: 60.8%). Ciprofloxacin was more extensively bound to plasma proteins in steers (percent bound: 49.6%) than in cows (percent bound: 33.8%). The steady state volume of distribution of enrofloxacin is comparable in cows (1.55
L/kg) and steers (1.59
L/kg). Within either bovine class, plasma elimination half-life of enrofloxacin and ciprofloxacin are comparable, while plasma protein binding was higher for enrofloxacin than for ciprofloxacin. Ciprofloxacin was more concentrated in milk than enrofloxacin.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>Beef</subject><subject>beef cattle</subject><subject>Blood Proteins - metabolism</subject><subject>Cattle</subject><subject>Cattle - blood</subject><subject>Cattle - metabolism</subject><subject>Chromatography</subject><subject>Ciprofloxacin</subject><subject>Ciprofloxacin - administration & dosage</subject><subject>Ciprofloxacin - blood</subject><subject>Ciprofloxacin - metabolism</subject><subject>Ciprofloxacin - pharmacokinetics</subject><subject>dairy cows</subject><subject>Enrofloxacin</subject><subject>Female</subject><subject>Fluoroquinolones - administration & dosage</subject><subject>Fluoroquinolones - blood</subject><subject>Fluoroquinolones - metabolism</subject><subject>Fluoroquinolones - pharmacokinetics</subject><subject>Half-Life</subject><subject>Injections, Intravenous</subject><subject>intravenous injection</subject><subject>Lactating cows</subject><subject>lactation</subject><subject>Male</subject><subject>Pharmacokinetics</subject><subject>Plasma</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Sex Characteristics</subject><subject>Steers</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EotPCC7CASCy6ynBtJ3YisalG_EmVWEDXlmNfFw-JPdiZKX0WXhaHKQh1AZIlS_Z3zv05hDyjsKZAxavtOh2yWTOAfk3ZGmj_gKxoy1nNhKAPyQqAN3XLuu6EnOa8BYCGUvmYnDCgrBecr8iPTZx2OunZH7DafdFp0iZ-9QFnb3IVXYUhRTfG79r4UOlgK-N3f72UM2ozF324rqz26bYy8Sb_IgdEV-UZMeXKxXGMNwvkw5z0AUPcF8pOPvg8L_VjuF_uCXnk9Jjx6d19Rq7evvm8eV9ffnz3YXNxWZsW2rlunXZOMz04KySV3LIBh7bpkQomezE4MGCsc9w6IbVrnCgba5AxaqQpG-Jn5PzoWwb7tsc8q8lng-OoA5YuVcd7Ibteyv-SslkwEIvny3vkNu5TKGMoCryFBkpOhWJHyqSYc0KndslPOt0WSC0Zq61aMlZLxooyVTIuoud31vthQvtH8jvUArw4Ak5Hpa-Tz-rqU_nlQLuuoXKp-_pIYFnrwWNS2XgMBq1PaGZlo_9XBz8BQZ_GAA</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Idowu, O.R.</creator><creator>Peggins, J.O.</creator><creator>Cullison, R.</creator><creator>Bredow, J. von</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin</title><author>Idowu, O.R. ; Peggins, J.O. ; Cullison, R. ; Bredow, J. von</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-5faffa2abfd67173d2beb549e162796bf0c0cdff3df67af4f62004e221c7c0343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - metabolism</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>Beef</topic><topic>beef cattle</topic><topic>Blood Proteins - metabolism</topic><topic>Cattle</topic><topic>Cattle - blood</topic><topic>Cattle - metabolism</topic><topic>Chromatography</topic><topic>Ciprofloxacin</topic><topic>Ciprofloxacin - administration & dosage</topic><topic>Ciprofloxacin - blood</topic><topic>Ciprofloxacin - metabolism</topic><topic>Ciprofloxacin - pharmacokinetics</topic><topic>dairy cows</topic><topic>Enrofloxacin</topic><topic>Female</topic><topic>Fluoroquinolones - administration & dosage</topic><topic>Fluoroquinolones - blood</topic><topic>Fluoroquinolones - metabolism</topic><topic>Fluoroquinolones - pharmacokinetics</topic><topic>Half-Life</topic><topic>Injections, Intravenous</topic><topic>intravenous injection</topic><topic>Lactating cows</topic><topic>lactation</topic><topic>Male</topic><topic>Pharmacokinetics</topic><topic>Plasma</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Sex Characteristics</topic><topic>Steers</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Idowu, O.R.</creatorcontrib><creatorcontrib>Peggins, J.O.</creatorcontrib><creatorcontrib>Cullison, R.</creatorcontrib><creatorcontrib>Bredow, J. von</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Idowu, O.R.</au><au>Peggins, J.O.</au><au>Cullison, R.</au><au>Bredow, J. von</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>89</volume><issue>2</issue><spage>230</spage><epage>235</epage><pages>230-235</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. The overall production of ciprofloxacin was slightly higher in steers than in cows (metabolite ratio: 64% and 59%, respectively). There was no significant difference in plasma protein binding of enrofloxacin between cows (percent bound: 59.4%) and steers (percent bound: 60.8%). Ciprofloxacin was more extensively bound to plasma proteins in steers (percent bound: 49.6%) than in cows (percent bound: 33.8%). The steady state volume of distribution of enrofloxacin is comparable in cows (1.55
L/kg) and steers (1.59
L/kg). Within either bovine class, plasma elimination half-life of enrofloxacin and ciprofloxacin are comparable, while plasma protein binding was higher for enrofloxacin than for ciprofloxacin. Ciprofloxacin was more concentrated in milk than enrofloxacin.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>20129633</pmid><doi>10.1016/j.rvsc.2009.12.019</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 2010-10, Vol.89 (2), p.230-235 |
| issn | 0034-5288 1532-2661 |
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| subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacokinetics Area Under Curve Beef beef cattle Blood Proteins - metabolism Cattle Cattle - blood Cattle - metabolism Chromatography Ciprofloxacin Ciprofloxacin - administration & dosage Ciprofloxacin - blood Ciprofloxacin - metabolism Ciprofloxacin - pharmacokinetics dairy cows Enrofloxacin Female Fluoroquinolones - administration & dosage Fluoroquinolones - blood Fluoroquinolones - metabolism Fluoroquinolones - pharmacokinetics Half-Life Injections, Intravenous intravenous injection Lactating cows lactation Male Pharmacokinetics Plasma Protein Binding Proteins Sex Characteristics Steers Veterinary medicine |
| title | Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin |
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