Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria

Cerebral malaria claims more than 1 million lives per year. We report that heme oxygenase-1 (HO-1, encoded by Hmox1 ) prevents the development of experimental cerebral malaria (ECM). BALB/c mice infected with Plasmodium berghei ANKA upregulated HO-1 expression and activity and did not develop ECM. D...

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Veröffentlicht in:	Nature medicine 2007-06, Vol.13 (6), p.703-710
Hauptverfasser:	Soares, Miguel P, Mota, Maria M, Pamplona, Ana, Ferreira, Ana, Balla, József, Jeney, Viktória, Balla, György, Epiphanio, Sabrina, Chora, Ângelo, Rodrigues, Cristina D, Gregoire, Isabel Pombo, Cunha-Rodrigues, Margarida, Portugal, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Brain Cancer Research Carbon monoxide Carbon Monoxide - physiology Disease Models, Animal Enzymes Heme - metabolism Heme Oxygenase-1 - deficiency Heme Oxygenase-1 - genetics Heme Oxygenase-1 - physiology Infectious Diseases Malaria Malaria, Cerebral - drug therapy Malaria, Cerebral - enzymology Malaria, Cerebral - metabolism Metabolic Diseases Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, SCID Molecular Medicine Neurosciences Oxidation Pathology Plasmodium berghei Vector-borne diseases
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