Clonal selection of 11q CN-LOH and CBL gene mutation in a serially studied patient during MDS progression to AML

Abstract By conventional metaphase and SNP array cytogenetics we serially studied a patient affected by high-risk myelodysplastic syndrome (MDS), documenting the conversion from partial trisomy 8q to trisomy 8 and partial tetrasomy 8q during progression to acute myeloid leukemia (AML). Moreover, the...

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Veröffentlicht in:	Leukemia research 2010-11, Vol.34 (11), p.1539-1542
Hauptverfasser:	Barresi, Vincenza, Palumbo, Giuseppe Alberto, Musso, Nicolò, Consoli, Carla, Capizzi, Carmela, Meli, Carmela Rita, Romano, Alessandra, Di Raimondo, Francesco, Condorelli, Daniele Filippo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia CBL gene Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 8 Clone Cells Copy-neutral loss of heterozygosity Disease Progression Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Loss of Heterozygosity Male Mutation Myelodysplastic syndrome Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - pathology Neoplasms, Second Primary Proto-Oncogene Proteins c-cbl - genetics SNP array Trisomy
Online-Zugang:	Volltext
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