Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

Complex I (NADH-ubiquinone reductase) and Complex III (ubiquinol-cytochrome c reductase) supplemented with NADH generated O 2 − at maximum rates of 9.8 and 6.5 nmol/min/mg of protein, respectively, while, in the presence of superoxide dismutase, the same systems generated H 2O 2 at maximum rates of...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1977-04, Vol.180 (2), p.248-257
Hauptverfasser:	Cadenas, Enrique, Boveris, Alberto, Ragan, C.Ian, Stoppani, Andres O.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal science Animals Cattle Cytochrome c Group - metabolism Cytochrome Reductases - metabolism Hydrogen Peroxide - metabolism Kinetics livestock Mitochondria, Muscle - enzymology Myocardium NADH, NADPH Oxidoreductases - metabolism Oxygen - metabolism Quinone Reductases - metabolism Rotenone - pharmacology Superoxide Dismutase Superoxides - metabolism Ubiquinone - metabolism Xanthine Oxidase zoology
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