Characterization of ligand binding, DNA binding and phosphorylation of progesterone receptor by two novel progesterone receptor antagonist ligands

In order to gain a better understanding of the distinctive mechanisms of the various types of antiprogestins, we have characterized in vitro ligand binding, specific DNA binding and phosphorylation of progesterone receptor (PR) from T47D cells after treatment of cells with progestins (progesterone,...

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Veröffentlicht in:	Molecular and cellular biochemistry 1997-10, Vol.175 (1-2), p.205-212
Hauptverfasser:	Hurd, C, Underwood, B, Herman, M, Iwasaki, K, Kloosterboer, H J, Dinda, S, Moudgil, V K
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Blotting, Western Deoxyribonucleic acid DNA DNA - drug effects DNA - metabolism Electrophoresis, Polyacrylamide Gel Estrenes - pharmacology Furans - pharmacology Gonanes - pharmacology Hormone Antagonists - pharmacology Humans Ligands Mifepristone - pharmacology Phosphorylation Phosphorylation - drug effects Progesterone Congeners - pharmacology Promegestone - pharmacology Proteins Receptors, Progesterone - antagonists & inhibitors Receptors, Progesterone - metabolism Sodium Dodecyl Sulfate Tumor Cells, Cultured
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